Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 837651..838325 Replicon chromosome
Accession NZ_CP002007
Organism Streptococcus suis 05HAS68

Toxin (Protein)


Gene name hicA Uniprot ID A0A123U128
Locus tag HAS68_RS04335 Protein ID WP_009910449.1
Coordinates 837651..837833 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A7Y6VEQ2
Locus tag HAS68_RS04340 Protein ID WP_009910448.1
Coordinates 837873..838325 (+) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HAS68_RS04290 832729..832932 + 204 WP_024409202.1 hypothetical protein -
HAS68_RS04295 832925..833128 + 204 WP_024409203.1 hypothetical protein -
HAS68_RS04300 833139..833405 + 267 WP_024409204.1 hypothetical protein -
HAS68_RS11575 833416..833574 + 159 WP_162841287.1 hypothetical protein -
HAS68_RS04305 833579..833794 + 216 WP_024409205.1 hypothetical protein -
HAS68_RS04310 833808..834602 + 795 WP_079269917.1 DnaD domain protein -
HAS68_RS04315 834618..835463 + 846 WP_024409207.1 ATP-binding protein -
HAS68_RS04320 835931..836371 + 441 WP_024409208.1 hypothetical protein -
HAS68_RS04325 836441..836941 + 501 WP_024409209.1 hypothetical protein -
HAS68_RS04330 837081..837467 + 387 WP_009910450.1 hypothetical protein -
HAS68_RS04335 837651..837833 + 183 WP_009910449.1 type II toxin-antitoxin system HicA family toxin Toxin
HAS68_RS04340 837873..838325 + 453 WP_009910448.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HAS68_RS04345 838437..838646 + 210 WP_009910447.1 hypothetical protein -
HAS68_RS04350 839753..839974 + 222 WP_012775256.1 hypothetical protein -
HAS68_RS04355 839976..840236 + 261 WP_009910443.1 type II toxin-antitoxin system RelE/ParE family toxin -
HAS68_RS04360 840403..841044 + 642 WP_002935700.1 HAD family hydrolase -
HAS68_RS04365 841077..841262 - 186 WP_002935693.1 hypothetical protein -
HAS68_RS04370 841326..842330 - 1005 WP_009910438.1 lactonase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 830147..841262 11115


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-82)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6681.93 Da        Isoelectric Point: 10.8207

>T44588 WP_009910449.1 NZ_CP002007:837651-837833 [Streptococcus suis 05HAS68]
MPMTQKEMVKLLTAHGWTKTKGGKGSHVKLEKVGERPITIPHGEINKYTERGIKKQAGLL

Download         Length: 183 bp

>T44588 NZ_CP002007:837651-837833 [Streptococcus suis 05HAS68]
ATGCCTATGACACAAAAAGAAATGGTTAAGCTACTTACCGCCCATGGTTGGACAAAAACTAAAGGTGGTAAGGGGTCTCA
CGTTAAACTTGAAAAAGTAGGCGAGCGACCTATAACCATTCCCCACGGTGAAATTAACAAATACACCGAAAGGGGTATCA
AAAAGCAAGCAGGGCTGTTATAA

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16672.68 Da        Isoelectric Point: 4.0098

>AT44588 WP_009910448.1 NZ_CP002007:837873-838325 [Streptococcus suis 05HAS68]
MLVTYPALFYYDDTDGATAPYFVTFPDFEHSATQGEDMADAMAMASDWLGIHLADYIENGRDIPTPTPINALSLADNNPF
RDDKDIELVYDPSKSFVSMVMVDVAEYLGSQEPVKKTLTIPRWADTLGRELGLNFSQTLTDAIADKKIHA

Download         Length: 453 bp

>AT44588 NZ_CP002007:837873-838325 [Streptococcus suis 05HAS68]
ATGCTTGTCACTTATCCAGCTTTATTTTATTATGACGATACAGACGGAGCTACCGCCCCTTATTTTGTCACTTTCCCAGA
CTTTGAACATTCAGCAACTCAGGGCGAAGATATGGCAGACGCTATGGCAATGGCTAGTGATTGGTTAGGTATTCATCTAG
CTGATTATATTGAGAATGGGCGTGATATTCCCACTCCTACCCCTATTAACGCTTTATCATTGGCTGATAATAACCCTTTC
CGTGATGATAAGGACATAGAGCTAGTTTATGACCCTAGCAAGTCTTTTGTATCTATGGTTATGGTTGACGTTGCTGAGTA
TCTAGGCAGTCAAGAGCCTGTAAAGAAAACACTAACTATTCCACGTTGGGCGGATACTTTAGGGCGTGAGTTAGGGCTAA
ATTTCTCACAGACCTTAACAGACGCTATTGCAGATAAGAAAATTCATGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A123U128

Antitoxin

Source ID Structure
AlphaFold DB A0A7Y6VEQ2

References