Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 507835..508321 Replicon chromosome
Accession NZ_CP002007
Organism Streptococcus suis 05HAS68

Toxin (Protein)


Gene name relE Uniprot ID D5AGV2
Locus tag HAS68_RS02730 Protein ID WP_011922754.1
Coordinates 508052..508321 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D5AGV1
Locus tag HAS68_RS02725 Protein ID WP_002938604.1
Coordinates 507835..508062 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HAS68_RS02700 503168..503713 - 546 WP_009909618.1 NAD(P)H-dependent oxidoreductase -
HAS68_RS02705 503776..504225 - 450 WP_009909619.1 MarR family transcriptional regulator -
HAS68_RS02710 504528..505025 + 498 WP_002938611.1 DUF5590 domain-containing protein -
HAS68_RS02715 505022..506203 + 1182 WP_002938610.1 pyridoxal phosphate-dependent aminotransferase -
HAS68_RS02720 506218..507564 + 1347 WP_013730302.1 asparagine--tRNA ligase -
HAS68_RS02725 507835..508062 + 228 WP_002938604.1 hypothetical protein Antitoxin
HAS68_RS02730 508052..508321 + 270 WP_011922754.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HAS68_RS02735 508727..510046 + 1320 WP_002937278.1 MATE family efflux transporter -
HAS68_RS02740 510230..510607 + 378 WP_013730303.1 RidA family protein -
HAS68_RS02745 510629..511516 + 888 WP_002937261.1 RNase adapter RapZ -
HAS68_RS02750 511513..512487 + 975 WP_002937257.1 YvcK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10437.49 Da        Isoelectric Point: 10.3916

>T44587 WP_011922754.1 NZ_CP002007:508052-508321 [Streptococcus suis 05HAS68]
MAYKLVLSDDALKQLKKMDRHVGMMLAKDLKKRLDGLENPRQFGKALVGDYKGLWRYRVGNYRVICDIIDNKMVILALEI
GHRKEIYKK

Download         Length: 270 bp

>T44587 NZ_CP002007:508052-508321 [Streptococcus suis 05HAS68]
ATGGCTTATAAGCTTGTTCTCAGCGATGATGCTTTGAAGCAGTTGAAAAAAATGGACAGGCATGTGGGGATGATGCTTGC
TAAGGATTTGAAAAAACGTTTGGACGGTTTGGAGAATCCAAGACAATTTGGGAAGGCCTTGGTAGGAGACTATAAGGGGC
TGTGGCGGTATAGAGTGGGGAATTACCGTGTAATTTGTGATATTATTGATAACAAAATGGTCATCCTGGCCCTTGAAATC
GGGCACCGGAAAGAAATCTATAAAAAATGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8450.51 Da        Isoelectric Point: 4.1589

>AT44587 WP_002938604.1 NZ_CP002007:507835-508062 [Streptococcus suis 05HAS68]
MGIVSLRLNDAEEEIFRSYAIHTGKSLSELFKTALAEQIEDQLDYEIGIKALKKFQENPVTHSIDDVLAELEDGL

Download         Length: 228 bp

>AT44587 NZ_CP002007:507835-508062 [Streptococcus suis 05HAS68]
ATGGGAATTGTATCCTTGCGATTAAACGATGCAGAAGAAGAAATTTTCAGAAGCTATGCTATTCATACAGGAAAAAGCCT
GTCTGAGCTATTCAAAACTGCACTTGCTGAACAGATAGAAGACCAGTTGGACTATGAAATTGGTATCAAGGCTTTGAAGA
AATTCCAAGAAAATCCTGTTACACACTCGATTGATGATGTTCTTGCGGAGTTAGAAGATGGCTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A126UKS2

Antitoxin

Source ID Structure
AlphaFold DB A0A140EXF0

References