Detailed information of TA system TA044582

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): abiEi-abiEii/AbiEii-AbiEi
• Location: 1055194..1056627
• Replicon: chromosome
• Accession: NZ_CP001668
• Organism: Mycoplasma mycoides subsp. capri str. GM12

Toxin (Protein)

• Gene name: abiEii
• Uniprot ID: -
• Locus tag: MMCAP2_RS04400
• Protein ID: WP_080511208.1
• Coordinates: 1055194..1055928 (-)
• Length: 245 a.a.

Antitoxin (Protein)

• Gene name: abiEi
• Uniprot ID: A0A7Z7PN10
• Locus tag: MMCAP2_RS04405
• Protein ID: WP_020863064.1
• Coordinates: 1056028..1056627 (-)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MMCAP2_RS04385 (MMCAP2_0886)	1051490..1053067	-	1578	WP_020863062.1	dicarboxylate/amino acid:cation symporter	-
MMCAP2_RS04390 (MMCAP2_0887)	1053087..1054430	-	1344	WP_023905986.1	CoA-disulfide reductase	-
MMCAP2_RS04395 (MMCAP2_0888)	1054648..1055148	+	501	WP_020863063.1	isochorismatase family protein	-
MMCAP2_RS04400 (MMCAP2_0889)	1055194..1055928	-	735	WP_080511208.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
MMCAP2_RS04405 (MMCAP2_0890)	1056028..1056627	-	600	WP_020863064.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
MMCAP2_RS05025	1056895..1057014	+	120	Protein_836	isochorismatase family protein	-
MMCAP2_RS04410 (MMCAP2_0891)	1057204..1058538	+	1335	WP_020863065.1	DUF285 domain-containing protein	-
MMCAP2_RS05145 (MMCAP2_0892)	1058788..1060011	+	1224	WP_020863066.1	phosphatase PAP2 family protein	-
MMCAP2_RS04420 (MMCAP2_0893)	1060142..1061347	+	1206	WP_020863067.1	phosphatase PAP2 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (4-210)

Antitoxin

• Transcriptional regulator, AbiEi antitoxin (5-53)

Sequences

Toxin

Protein

• Length: 245 a.a.
• Molecular weight: 28915.65 Da
• Isoelectric Point: 9.5052

>T44582 WP_080511208.1 NZ_CP001668:c1055928-1055194 [Mycoplasma mycoides subsp. capri str. GM12]
MKKISKNKDKINIIFKGGFLLSNIIGIKERTTKDIDYLLNNIVFSPDRIKELFEDILDYKKGDKIHFQIQKINEIKKKEK
YTGFRITVECKLDEIVEIIKIDVATGDIITSCQVRYNIENIFHNNSFYVYGYNLETMLAEKIHAIKELSLFNTRTKDFYD
IYLIYNLKRDDIDYMTLKNACINTFKQRNSIFDKDDLLELLNKIKNSQSTHNLTKQKNIYFYNKNIDFKFIIQSIIELIK
NIK

Nucleotide

• Length: 735 bp

>T44582 NZ_CP001668:c1055928-1055194 [Mycoplasma mycoides subsp. capri str. GM12]
CTGAAAAAAATATCTAAGAATAAGGATAAGATAAATATCATATTTAAAGGAGGTTTTTTGCTTTCTAATATAATTGGAAT
AAAAGAAAGAACAACCAAAGATATTGATTATTTATTAAATAACATTGTATTTTCACCTGATCGTATAAAAGAATTATTTG
AAGATATTTTAGATTATAAGAAAGGAGATAAAATACATTTTCAAATTCAAAAAATAAATGAAATTAAGAAAAAAGAAAAA
TATACAGGTTTTAGAATAACTGTAGAATGCAAATTAGATGAAATAGTAGAAATTATAAAAATAGATGTAGCAACAGGTGA
TATCATCACTTCCTGTCAAGTTAGATATAATATTGAAAATATTTTTCATAACAACAGTTTTTATGTTTATGGTTATAACT
TAGAAACTATGTTGGCTGAAAAAATTCATGCAATCAAAGAATTAAGCTTGTTTAATACTAGAACAAAAGATTTCTATGAT
ATATACCTAATTTATAATTTAAAAAGAGATGATATTGACTATATGACGTTGAAAAATGCTTGTATTAATACATTCAAACA
AAGAAACAGCATTTTTGATAAAGACGATTTATTAGAGTTACTCAATAAAATAAAAAATTCGCAATCTACTCATAATTTAT
GAACTAAACAAAAAAATATATATTTTTATAATAAAAACATAGATTTTAAATTTATCATTCAGTCAATTATTGAACTTATT
AAAAACATTAAATAG

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 23847.67 Da
• Isoelectric Point: 8.3457

>AT44582 WP_020863064.1 NZ_CP001668:c1056627-1056028 [Mycoplasma mycoides subsp. capri str. GM12]
MNYVEKIKEKAIQNNGLITRKEIISLKIPPIYITRMVRKKELEKIDIGIYALTSLDNYPYDPEFNFCSRYQVPVFSYVYA
LNLFDFTDVIPLNFEVTVYKGYNAHNLKPNTIVHYVNKEIFNLGITEIRNAFGNWVRTYDIERTICDLIKNRKNINVELF
VKTMNNYVNYEKKDWNKLYEYAEKMHIEKELVEIFQLII

Nucleotide

• Length: 600 bp

>AT44582 NZ_CP001668:c1056627-1056028 [Mycoplasma mycoides subsp. capri str. GM12]
ATGAACTATGTAGAAAAAATAAAAGAAAAAGCCATTCAAAATAATGGACTAATAACAAGAAAAGAAATTATAAGTCTAAA
AATCCCACCTATTTATATAACTAGAATGGTAAGAAAAAAAGAACTTGAAAAAATTGATATTGGAATTTATGCACTAACTT
CACTAGATAATTATCCTTACGATCCCGAATTTAATTTTTGTTCAAGATATCAAGTTCCTGTTTTTTCATATGTTTATGCA
TTAAACTTATTTGATTTTACTGATGTTATTCCACTTAATTTTGAAGTAACTGTTTATAAAGGGTATAATGCACATAATCT
TAAACCTAACACAATAGTTCACTATGTTAATAAAGAAATTTTTAATCTAGGAATTACTGAAATTAGAAATGCTTTTGGAA
ATTGGGTAAGAACCTATGATATTGAAAGAACAATTTGTGATCTTATTAAAAATAGAAAAAATATTAATGTTGAACTTTTT
GTAAAAACTATGAATAACTATGTTAATTATGAAAAAAAGGACTGGAATAAACTTTATGAATATGCTGAAAAAATGCACAT
TGAAAAAGAGCTAGTAGAAATATTTCAACTTATTATTTAA

Structures

Antitoxin

• AlphaFold DB: A0A7Z7PN10