Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-ChpS
Location 1272076..1272620 Replicon chromosome
Accession NZ_AP028139
Organism Polynucleobacter sp. HIN8

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag QUE65_RS06720 Protein ID WP_286280229.1
Coordinates 1272076..1272402 (-) Length 109 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag QUE65_RS06725 Protein ID WP_286280230.1
Coordinates 1272402..1272620 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QUE65_RS06695 (PHIN8_12940) 1267508..1268374 - 867 WP_286280218.1 dihydropteroate synthase -
QUE65_RS06700 (PHIN8_12950) 1268377..1270260 - 1884 WP_215369083.1 ATP-dependent zinc metalloprotease FtsH -
QUE65_RS06705 (PHIN8_12960) 1270423..1271088 - 666 WP_286280221.1 RlmE family RNA methyltransferase -
QUE65_RS06710 (PHIN8_12970) 1271144..1271599 + 456 WP_286280223.1 YhbY family RNA-binding protein -
QUE65_RS06715 (PHIN8_12980) 1271567..1272067 - 501 WP_286280225.1 DUF4149 domain-containing protein -
QUE65_RS06720 (PHIN8_12990) 1272076..1272402 - 327 WP_286280229.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
QUE65_RS06725 (PHIN8_13000) 1272402..1272620 - 219 WP_286280230.1 antitoxin Antitoxin
QUE65_RS06730 (PHIN8_13010) 1272721..1273203 - 483 WP_215369105.1 transcription elongation factor GreA -
QUE65_RS06735 (PHIN8_13020) 1273242..1276490 - 3249 WP_286280233.1 carbamoyl-phosphate synthase large subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-106)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 11502.43 Da        Isoelectric Point: 10.3155

>T44572 WP_286280229.1 NZ_AP028139:c1272402-1272076 [Polynucleobacter sp. HIN8]
MKRGDIYLVSLDPTAGHEQKGYRPVLVVSPAPFNQLTKTPIVVPISTGGQFARVAGFAVELVGTKTTGIARCDQPRTLDL
VARKAKRVETVSSAVIDDVLAKLATLVT

Download         Length: 327 bp

>T44572 NZ_AP028139:c1272402-1272076 [Polynucleobacter sp. HIN8]
ATGAAGCGAGGTGATATTTATTTGGTATCTCTTGATCCAACGGCTGGTCATGAGCAAAAAGGGTATCGACCTGTATTGGT
CGTGTCACCAGCACCGTTTAATCAACTAACCAAGACCCCAATTGTTGTGCCGATTTCAACTGGCGGACAGTTTGCCCGGG
TTGCAGGGTTTGCAGTCGAGCTGGTTGGAACTAAAACCACAGGGATTGCTCGCTGCGATCAACCTCGCACCCTAGACCTC
GTGGCGCGTAAAGCAAAACGCGTTGAGACCGTGTCTTCGGCAGTTATCGATGATGTTTTGGCTAAACTGGCAACCTTAGT
CACTTAG

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 7824.12 Da        Isoelectric Point: 4.3285

>AT44572 WP_286280230.1 NZ_AP028139:c1272620-1272402 [Polynucleobacter sp. HIN8]
MLTVSPVFLKELQIACGSTVDVALVEGQLVVRPVTKPQYALADLLAQCDPKAKMPSEDRQWLDSSPVGNEIL

Download         Length: 219 bp

>AT44572 NZ_AP028139:c1272620-1272402 [Polynucleobacter sp. HIN8]
ATGCTGACAGTGTCCCCGGTTTTCCTTAAAGAACTTCAGATTGCGTGTGGATCAACCGTTGATGTCGCTCTGGTGGAAGG
GCAATTGGTCGTACGACCTGTTACTAAGCCTCAATATGCACTCGCTGATTTATTAGCGCAGTGCGATCCAAAAGCAAAAA
TGCCAAGCGAGGATCGGCAGTGGCTGGATAGCTCCCCTGTAGGTAATGAGATTCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References