Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 1111255..1111810 Replicon chromosome
Accession NZ_AP028136
Organism Polynucleobacter sp. HIN5

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag QUE61_RS05860 Protein ID WP_286306330.1
Coordinates 1111255..1111566 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag QUE61_RS05865 Protein ID WP_286306331.1
Coordinates 1111553..1111810 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QUE61_RS05840 (PHIN5_11340) 1106469..1107506 - 1038 WP_286306326.1 tripartite tricarboxylate transporter substrate binding protein -
QUE61_RS05845 (PHIN5_11350) 1107726..1108562 + 837 WP_286306327.1 3-keto-5-aminohexanoate cleavage protein -
QUE61_RS05850 (PHIN5_11360) 1108563..1109438 - 876 WP_286306328.1 fumarylacetoacetate hydrolase family protein -
QUE61_RS05855 (PHIN5_11370) 1109773..1111041 + 1269 WP_286306329.1 putative Na+/H+ antiporter -
QUE61_RS05860 (PHIN5_11380) 1111255..1111566 - 312 WP_286306330.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QUE61_RS05865 (PHIN5_11390) 1111553..1111810 - 258 WP_286306331.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
QUE61_RS05870 (PHIN5_11400) 1112387..1113799 + 1413 WP_286306333.1 circularly permuted type 2 ATP-grasp protein -
QUE61_RS05875 (PHIN5_11410) 1113812..1114789 + 978 WP_286280154.1 alpha-E domain-containing protein -
QUE61_RS05880 (PHIN5_11420) 1114758..1115603 + 846 WP_286306334.1 transglutaminase family protein -
QUE61_RS05885 (PHIN5_11430) 1115605..1116441 + 837 WP_286306335.1 peptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(12-75)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12120.32 Da        Isoelectric Point: 10.4970

>T44565 WP_286306330.1 NZ_AP028136:c1111566-1111255 [Polynucleobacter sp. HIN5]
MRIYKLEFHVLAKKEWDKLDGSLKEQFKKQLEKRLVTPHIPSSLLSRELEGCYKIKLRTSGYRLVYEVADKRVTVIVIAV
GKRDKDEAYQKAVKRYIHKVSGK

Download         Length: 312 bp

>T44565 NZ_AP028136:c1111566-1111255 [Polynucleobacter sp. HIN5]
TTGAGGATCTATAAGCTAGAGTTCCATGTTTTAGCCAAAAAAGAGTGGGATAAGTTGGATGGTTCTTTAAAAGAACAGTT
CAAGAAGCAATTAGAAAAACGTCTGGTGACACCTCATATTCCATCGTCACTGTTAAGCCGGGAGTTAGAAGGTTGCTACA
AAATTAAATTACGAACTAGTGGCTATCGTCTTGTCTATGAAGTAGCAGATAAGCGAGTAACAGTGATTGTGATAGCGGTT
GGTAAGCGAGATAAAGATGAGGCTTACCAAAAAGCAGTAAAACGATATATCCATAAAGTGTCGGGTAAATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9362.92 Da        Isoelectric Point: 8.5495

>AT44565 WP_286306331.1 NZ_AP028136:c1111810-1111553 [Polynucleobacter sp. HIN5]
MNTLTPIHAGTTISVTDLRKLTPSKIIEQAGGNPVAILSHNKPEAYLLSAKVYEKILDALDDLELIKIVEKRRGGKTIRV
NLEDL

Download         Length: 258 bp

>AT44565 NZ_AP028136:c1111810-1111553 [Polynucleobacter sp. HIN5]
ATGAATACACTTACACCGATTCATGCAGGGACAACAATCAGTGTGACTGATTTAAGAAAGTTAACGCCGAGCAAAATCAT
TGAGCAAGCAGGGGGTAATCCTGTTGCTATCCTTAGTCACAACAAGCCTGAGGCATATTTGTTATCTGCAAAAGTATATG
AAAAAATTTTGGATGCTTTGGATGACCTTGAATTAATTAAAATTGTTGAAAAGAGACGTGGTGGTAAAACTATTAGGGTA
AACCTTGAGGATCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References