Detailed information of TA system TA044559

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3194067..3194730
• Replicon: chromosome
• Accession: NZ_AP028106
• Organism: Edwardsiella ictaluri strain KH201010

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: C5BAS3
• Locus tag: QUF09_RS15080
• Protein ID: WP_015872556.1
• Coordinates: 3194067..3194483 (-)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: C5BAS4
• Locus tag: QUF09_RS15085
• Protein ID: WP_015872557.1
• Coordinates: 3194464..3194730 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QUF09_RS15060 (KH201010_29210)	3189991..3191724	-	1734	WP_015872552.1	single-stranded-DNA-specific exonuclease RecJ	-
QUF09_RS15065 (KH201010_29220)	3191729..3192445	-	717	WP_015872553.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
QUF09_RS15070 (KH201010_29230)	3192473..3193372	-	900	WP_015872554.1	site-specific tyrosine recombinase XerD	-
QUF09_RS15075 (KH201010_29240)	3193530..3194042	+	513	WP_015872555.1	flavodoxin FldB	-
QUF09_RS15080 (KH201010_29250)	3194067..3194483	-	417	WP_015872556.1	protein YgfX	Toxin
QUF09_RS15085 (KH201010_29260)	3194464..3194730	-	267	WP_015872557.1	FAD assembly factor SdhE	Antitoxin
QUF09_RS15090 (KH201010_29270)	3195078..3196073	+	996	WP_015872558.1	tRNA-modifying protein YgfZ	-
QUF09_RS15095 (KH201010_29280)	3196114..3196938	-	825	WP_015872559.1	shikimate 5-dehydrogenase	-
QUF09_RS15100 (KH201010_29290)	3197100..3197972	-	873	WP_015872560.1	nucleoside-specific channel-forming protein Tsx	-
QUF09_RS15105 (KH201010_29300)	3198581..3199231	+	651	WP_035609190.1	hemolysin III family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 16145.89 Da
• Isoelectric Point: 11.3233

>T44559 WP_015872556.1 NZ_AP028106:c3194483-3194067 [Edwardsiella ictaluri]
VALWRCNVHASWRTQVMFLLGHGALVLAILLAPWPENYSVFWLILLVAVIFECIRSQRLIARNSGELQRLAPQVWHWQLR
EWRLARRPWVSDLGALLILQSTHGTPCRRRLWLAADSMSREEWGQLRRALLDTGDDRV

Nucleotide

• Length: 417 bp

>T44559 NZ_AP028106:c3194483-3194067 [Edwardsiella ictaluri]
GTGGCCCTTTGGCGCTGTAATGTTCACGCCTCCTGGCGTACCCAGGTGATGTTTCTGCTGGGGCATGGCGCGCTGGTATT
GGCGATCCTGTTGGCGCCCTGGCCGGAAAACTACAGCGTATTCTGGCTGATTCTGCTGGTTGCGGTGATCTTTGAGTGTA
TCCGCAGCCAGCGTCTGATTGCGCGTAACAGCGGTGAGCTACAGCGGCTGGCCCCACAGGTATGGCACTGGCAGCTGCGC
GAGTGGCGCCTGGCCCGGCGCCCCTGGGTTAGCGATCTGGGAGCGTTGCTGATCCTGCAGAGTACCCATGGCACGCCGTG
CCGCCGTCGTCTGTGGCTGGCGGCCGACAGCATGAGCCGCGAAGAGTGGGGGCAGCTGCGCCGCGCGCTGCTCGATACGG
GCGACGATCGCGTATAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10364.92 Da
• Isoelectric Point: 5.6951

>AT44559 WP_015872557.1 NZ_AP028106:c3194730-3194464 [Edwardsiella ictaluri]
MDINNKARVHWACRRGMRELDIAIMPFFEHEYDALNDADKQTFVRLLSCDDPELFKWLMNQGKPDDTDLARMITLIQTRN
KERGPLAL

Nucleotide

• Length: 267 bp

>AT44559 NZ_AP028106:c3194730-3194464 [Edwardsiella ictaluri]
ATGGATATCAATAATAAAGCGCGGGTTCACTGGGCGTGCCGCCGCGGAATGCGTGAGCTGGATATCGCCATTATGCCTTT
CTTTGAACATGAGTATGATGCGCTTAACGATGCCGATAAACAGACCTTTGTCCGACTGCTGTCCTGTGACGATCCTGAAC
TATTTAAATGGCTGATGAACCAGGGTAAGCCGGACGATACCGATCTGGCCCGTATGATTACGCTGATTCAGACGCGAAAT
AAAGAACGTGGCCCTTTGGCGCTGTAA

Structures

Toxin

• AlphaFold DB: C5BAS3

Antitoxin

• AlphaFold DB: C5BAS4