Detailed information of TA system TA044555

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-DnaT
• Location: 1956620..1957142
• Replicon: chromosome
• Accession: NZ_AP028106
• Organism: Edwardsiella ictaluri strain KH201010

Toxin (Protein)

• Gene name: relE
• Uniprot ID: C5BBL4
• Locus tag: QUF09_RS09215
• Protein ID: WP_015871319.1
• Coordinates: 1956861..1957142 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: C5BBL3
• Locus tag: QUF09_RS09210
• Protein ID: WP_015871318.1
• Coordinates: 1956620..1956871 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QUF09_RS09180 (KH201010_17940)	1951776..1952438	-	663	WP_015871312.1	hypothetical protein	-
QUF09_RS09185 (KH201010_17950)	1952438..1953019	-	582	WP_049640652.1	hypothetical protein	-
QUF09_RS09190 (KH201010_17960)	1953019..1953462	-	444	WP_015871314.1	hypothetical protein	-
QUF09_RS09195 (KH201010_17970)	1953504..1953899	-	396	WP_049640651.1	hypothetical protein	-
QUF09_RS09200 (KH201010_17980)	1954057..1955313	-	1257	WP_198077050.1	N4-gp56 family major capsid protein	-
QUF09_RS09205 (KH201010_17990)	1955331..1956332	-	1002	WP_015871317.1	hypothetical protein	-
QUF09_RS09210 (KH201010_18000)	1956620..1956871	+	252	WP_015871318.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
QUF09_RS09215 (KH201010_18010)	1956861..1957142	+	282	WP_015871319.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
QUF09_RS09220 (KH201010_18020)	1957214..1959328	-	2115	WP_015871320.1	hypothetical protein	-
QUF09_RS09225 (KH201010_18030)	1959325..1960986	-	1662	WP_050977403.1	terminase	-
QUF09_RS09230 (KH201010_18040)	1960979..1961401	-	423	WP_232347283.1	hypothetical protein	-
QUF09_RS09235 (KH201010_18050)	1961536..1961763	-	228	WP_232347284.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1923603..1990698	67095

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-84)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10783.62 Da
• Isoelectric Point: 10.6993

>T44555 WP_015871319.1 NZ_AP028106:1956861-1957142 [Edwardsiella ictaluri]
MTYKLSFEKRALKEWKKLAPPIQSQLKKKLIERLENPHVPAARLSGRANRYKIKLRSSGYRLVYEVNDSEIILLVIAIGK
RADNEVYQAADSR

Nucleotide

• Length: 282 bp

>T44555 NZ_AP028106:1956861-1957142 [Edwardsiella ictaluri]
ATGACCTATAAACTGAGCTTTGAAAAGCGAGCCCTGAAAGAGTGGAAAAAACTGGCACCGCCGATTCAAAGCCAGTTGAA
AAAGAAACTGATCGAACGCCTGGAAAACCCACATGTTCCAGCAGCACGCTTAAGTGGGCGCGCTAACCGTTATAAAATAA
AATTACGCTCTTCCGGTTACCGGTTAGTTTATGAAGTCAACGATAGCGAAATCATCCTGCTGGTGATCGCTATCGGTAAA
CGGGCCGATAACGAGGTGTACCAAGCGGCAGACAGTCGTTAG

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9155.24 Da
• Isoelectric Point: 3.7550

>AT44555 WP_015871318.1 NZ_AP028106:1956620-1956871 [Edwardsiella ictaluri]
MAYQILTTTAASITDLKRNPMGTIAEGDGNAVAILNRNEPAFYCVPPELYAYYLELAEDAALNRIADERLEDAEFVSVNI
DDL

Nucleotide

• Length: 252 bp

>AT44555 NZ_AP028106:1956620-1956871 [Edwardsiella ictaluri]
ATGGCATACCAAATTCTCACGACCACCGCCGCCAGCATTACCGACCTGAAACGCAATCCAATGGGTACCATTGCTGAAGG
TGACGGCAATGCCGTAGCAATCTTAAACCGGAATGAGCCGGCCTTTTACTGCGTTCCACCGGAACTCTACGCTTACTATC
TGGAGCTGGCTGAAGATGCGGCGCTTAATCGTATCGCCGATGAGCGTCTGGAGGACGCTGAGTTTGTCAGCGTAAATATC
GATGACCTATAA

Structures

Toxin

• AlphaFold DB: C5BBL4

Antitoxin

• AlphaFold DB: C5BBL3