Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1108899..1109491 Replicon chromosome
Accession NZ_AP028106
Organism Edwardsiella ictaluri strain KH201010

Toxin (Protein)


Gene name Hha Uniprot ID D0ZEC2
Locus tag QUF09_RS05160 Protein ID WP_012847872.1
Coordinates 1108899..1109102 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID C5BCY7
Locus tag QUF09_RS05165 Protein ID WP_015870487.1
Coordinates 1109123..1109491 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QUF09_RS05120 (KH201010_10040) 1104119..1104580 + 462 WP_015870480.1 Lrp/AsnC family transcriptional regulator -
QUF09_RS05125 (KH201010_10050) 1104609..1104776 - 168 WP_015870481.1 hypothetical protein -
QUF09_RS05130 (KH201010_10060) 1104879..1105217 + 339 WP_015870482.1 P-II family nitrogen regulator -
QUF09_RS05135 (KH201010_10070) 1105239..1106519 + 1281 WP_198077273.1 ammonium transporter AmtB -
QUF09_RS05140 (KH201010_10080) 1106553..1107419 - 867 WP_015870484.1 acyl-CoA thioesterase II -
QUF09_RS05145 (KH201010_10090) 1107465..1107794 - 330 WP_015870485.1 MGMT family protein -
QUF09_RS05155 1108772..1108879 + 108 Protein_988 IS5/IS1182 family transposase -
QUF09_RS05160 (KH201010_10110) 1108899..1109102 - 204 WP_012847872.1 HHA domain-containing protein Toxin
QUF09_RS05165 (KH201010_10120) 1109123..1109491 - 369 WP_015870487.1 Hha toxicity modulator TomB Antitoxin
QUF09_RS05170 (KH201010_10130) 1109851..1113003 - 3153 WP_015870488.1 efflux RND transporter permease subunit -
QUF09_RS05175 (KH201010_10140) 1113047..1114231 - 1185 WP_015870489.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-115)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8103.37 Da        Isoelectric Point: 5.0914

>T44554 WP_012847872.1 NZ_AP028106:c1109102-1108899 [Edwardsiella ictaluri]
MTKIDYLMKLRKCTTLDTLERVIEKNKYELSDDELEIFYSAADHRLAELTMNKLYDKIPAEVWQYVR

Download         Length: 204 bp

>T44554 NZ_AP028106:c1109102-1108899 [Edwardsiella ictaluri]
ATGACAAAAATCGATTATCTGATGAAGTTGCGTAAATGCACGACGCTGGATACTCTGGAACGCGTGATCGAAAAGAACAA
ATACGAACTTTCAGATGATGAGCTGGAAATTTTTTATTCTGCCGCAGATCATCGACTGGCTGAATTAACCATGAATAAAC
TATACGACAAAATTCCGGCAGAAGTTTGGCAATACGTCCGCTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14287.03 Da        Isoelectric Point: 5.4786

>AT44554 WP_015870487.1 NZ_AP028106:c1109491-1109123 [Edwardsiella ictaluri]
MDENTSYQHDISELKYLCDYLYHQGIDVLGESNHGWVSDPTAEVNLQLNELIEHIASIAQSFKIKYPRHSDLAEMLDYYL
DETYALFGTYSISETALRQWLRTKRRMAYCLAHEKRNAALHV

Download         Length: 369 bp

>AT44554 NZ_AP028106:c1109491-1109123 [Edwardsiella ictaluri]
ATGGATGAGAACACTTCTTATCAGCATGACATCTCAGAGTTAAAATACCTGTGTGATTACCTGTATCATCAGGGAATAGA
TGTCTTGGGAGAAAGCAATCACGGCTGGGTCAGCGATCCGACGGCAGAAGTAAATCTACAGCTTAACGAGCTGATTGAGC
ATATTGCCAGCATCGCGCAATCATTTAAGATCAAATATCCGCGTCATTCGGATTTAGCCGAAATGCTGGATTATTATCTG
GATGAAACCTATGCCCTGTTTGGCACCTATAGCATAAGTGAAACGGCGCTCAGGCAATGGTTGCGTACCAAACGTCGGAT
GGCATACTGTCTGGCGCATGAAAAGCGCAACGCTGCCTTACATGTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A034SMG4

Antitoxin

Source ID Structure
AlphaFold DB C5BCY7

References