Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tad-ata/COG5606-COG4679 |
| Location | 888474..889137 | Replicon | chromosome |
| Accession | NZ_AP028106 | ||
| Organism | Edwardsiella ictaluri strain KH201010 | ||
Toxin (Protein)
| Gene name | tad | Uniprot ID | C5B7U4 |
| Locus tag | QUF09_RS04150 | Protein ID | WP_015870280.1 |
| Coordinates | 888793..889137 (-) | Length | 115 a.a. |
Antitoxin (Protein)
| Gene name | ata | Uniprot ID | - |
| Locus tag | QUF09_RS04145 | Protein ID | WP_015870279.1 |
| Coordinates | 888474..888791 (-) | Length | 106 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QUF09_RS04100 (KH201010_07910) | 883805..884353 | + | 549 | WP_015870271.1 | YaeQ family protein | - |
| QUF09_RS04105 (KH201010_07920) | 884355..884771 | + | 417 | WP_015870272.1 | alternative ribosome rescue aminoacyl-tRNA hydrolase ArfB | - |
| QUF09_RS04110 (KH201010_07930) | 884868..885545 | + | 678 | WP_015870273.1 | envelope stress response activation lipoprotein NlpE | - |
| QUF09_RS04115 (KH201010_07940) | 885567..885827 | - | 261 | WP_015870274.1 | YfhL family 4Fe-4S dicluster ferredoxin | - |
| QUF09_RS04120 | 886426..886710 | + | 285 | WP_050977424.1 | hypothetical protein | - |
| QUF09_RS04130 (KH201010_07970) | 887655..887834 | + | 180 | WP_071525714.1 | hypothetical protein | - |
| QUF09_RS04135 (KH201010_07980) | 887939..888067 | + | 129 | WP_015870277.1 | hypothetical protein | - |
| QUF09_RS04140 (KH201010_07990) | 888064..888441 | + | 378 | WP_015870278.1 | type II toxin-antitoxin system death-on-curing family toxin | - |
| QUF09_RS04145 (KH201010_08000) | 888474..888791 | - | 318 | WP_015870279.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| QUF09_RS04150 (KH201010_08010) | 888793..889137 | - | 345 | WP_015870280.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| QUF09_RS04155 | 889309..889527 | - | 219 | WP_232347353.1 | head completion/stabilization protein | - |
| QUF09_RS04160 (KH201010_08030) | 889556..890245 | + | 690 | WP_015870281.1 | phage portal protein | - |
| QUF09_RS04165 (KH201010_08050) | 891373..892220 | - | 848 | Protein_792 | MurR/RpiR family transcriptional regulator | - |
| QUF09_RS04170 (KH201010_08060) | 892421..893020 | + | 600 | WP_286329806.1 | phosphatidylglycerophosphatase C | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 115 a.a. Molecular weight: 12544.34 Da Isoelectric Point: 9.8474
>T44553 WP_015870280.1 NZ_AP028106:c889137-888793 [Edwardsiella ictaluri]
MKSLYWVGSTKKDLQSLPEEVQDIFGYALHLAQVGGKHSQTKPLKGFSGAGVLEVVEDFLGDTYRAVYTVKFGDAVYVSH
VFQKKSSSGIATPKLNMDKIRERLKAAENHARGA
MKSLYWVGSTKKDLQSLPEEVQDIFGYALHLAQVGGKHSQTKPLKGFSGAGVLEVVEDFLGDTYRAVYTVKFGDAVYVSH
VFQKKSSSGIATPKLNMDKIRERLKAAENHARGA
Download Length: 345 bp
>T44553 NZ_AP028106:c889137-888793 [Edwardsiella ictaluri]
ATGAAGTCACTATATTGGGTTGGTAGTACAAAAAAAGACCTCCAGTCATTGCCTGAAGAAGTACAGGATATTTTCGGCTA
TGCCCTGCATCTGGCACAGGTAGGAGGTAAACACTCACAGACCAAGCCACTGAAGGGGTTTAGTGGAGCTGGCGTACTTG
AGGTAGTAGAAGACTTTCTCGGTGATACTTATCGTGCAGTGTATACCGTTAAGTTCGGTGATGCCGTCTACGTTTCGCAC
GTATTCCAGAAAAAGTCTTCATCGGGAATCGCCACGCCAAAGCTCAATATGGACAAGATCCGCGAACGGCTAAAAGCCGC
AGAAAACCATGCCAGAGGAGCATAA
ATGAAGTCACTATATTGGGTTGGTAGTACAAAAAAAGACCTCCAGTCATTGCCTGAAGAAGTACAGGATATTTTCGGCTA
TGCCCTGCATCTGGCACAGGTAGGAGGTAAACACTCACAGACCAAGCCACTGAAGGGGTTTAGTGGAGCTGGCGTACTTG
AGGTAGTAGAAGACTTTCTCGGTGATACTTATCGTGCAGTGTATACCGTTAAGTTCGGTGATGCCGTCTACGTTTCGCAC
GTATTCCAGAAAAAGTCTTCATCGGGAATCGCCACGCCAAAGCTCAATATGGACAAGATCCGCGAACGGCTAAAAGCCGC
AGAAAACCATGCCAGAGGAGCATAA
Antitoxin
Download Length: 106 a.a. Molecular weight: 11480.41 Da Isoelectric Point: 10.2058
>AT44553 WP_015870279.1 NZ_AP028106:c888791-888474 [Edwardsiella ictaluri]
MSHDIEVSSGNVYVDIGRDDAEEMLLKAQLATTIGNIIKSRSLTQEQAAKLLGMTQPKLSNMLRGQFRGISEAKMLECLT
RLGRDVQIVVGKPRRTPGSVKVVLA
MSHDIEVSSGNVYVDIGRDDAEEMLLKAQLATTIGNIIKSRSLTQEQAAKLLGMTQPKLSNMLRGQFRGISEAKMLECLT
RLGRDVQIVVGKPRRTPGSVKVVLA
Download Length: 318 bp
>AT44553 NZ_AP028106:c888791-888474 [Edwardsiella ictaluri]
ATGAGCCATGATATTGAAGTCAGCAGCGGCAACGTTTATGTCGATATTGGCAGAGATGATGCCGAGGAAATGCTGTTAAA
AGCTCAGCTTGCCACCACTATTGGAAACATCATTAAAAGCCGTAGCCTGACGCAAGAACAAGCAGCAAAACTGCTGGGGA
TGACGCAGCCCAAACTGTCCAATATGCTGCGTGGGCAGTTCCGGGGCATCAGTGAAGCCAAAATGCTGGAATGTCTGACC
CGCTTAGGGCGCGACGTGCAAATCGTGGTTGGAAAGCCGCGCCGGACGCCGGGTAGCGTGAAAGTAGTGTTAGCCTGA
ATGAGCCATGATATTGAAGTCAGCAGCGGCAACGTTTATGTCGATATTGGCAGAGATGATGCCGAGGAAATGCTGTTAAA
AGCTCAGCTTGCCACCACTATTGGAAACATCATTAAAAGCCGTAGCCTGACGCAAGAACAAGCAGCAAAACTGCTGGGGA
TGACGCAGCCCAAACTGTCCAATATGCTGCGTGGGCAGTTCCGGGGCATCAGTGAAGCCAAAATGCTGGAATGTCTGACC
CGCTTAGGGCGCGACGTGCAAATCGTGGTTGGAAAGCCGCGCCGGACGCCGGGTAGCGTGAAAGTAGTGTTAGCCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|