Detailed information of TA system TA044553

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tad-ata/COG5606-COG4679
• Location: 888474..889137
• Replicon: chromosome
• Accession: NZ_AP028106
• Organism: Edwardsiella ictaluri strain KH201010

Toxin (Protein)

• Gene name: tad
• Uniprot ID: C5B7U4
• Locus tag: QUF09_RS04150
• Protein ID: WP_015870280.1
• Coordinates: 888793..889137 (-)
• Length: 115 a.a.

Antitoxin (Protein)

• Gene name: ata
• Uniprot ID: -
• Locus tag: QUF09_RS04145
• Protein ID: WP_015870279.1
• Coordinates: 888474..888791 (-)
• Length: 106 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QUF09_RS04100 (KH201010_07910)	883805..884353	+	549	WP_015870271.1	YaeQ family protein	-
QUF09_RS04105 (KH201010_07920)	884355..884771	+	417	WP_015870272.1	alternative ribosome rescue aminoacyl-tRNA hydrolase ArfB	-
QUF09_RS04110 (KH201010_07930)	884868..885545	+	678	WP_015870273.1	envelope stress response activation lipoprotein NlpE	-
QUF09_RS04115 (KH201010_07940)	885567..885827	-	261	WP_015870274.1	YfhL family 4Fe-4S dicluster ferredoxin	-
QUF09_RS04120	886426..886710	+	285	WP_050977424.1	hypothetical protein	-
QUF09_RS04130 (KH201010_07970)	887655..887834	+	180	WP_071525714.1	hypothetical protein	-
QUF09_RS04135 (KH201010_07980)	887939..888067	+	129	WP_015870277.1	hypothetical protein	-
QUF09_RS04140 (KH201010_07990)	888064..888441	+	378	WP_015870278.1	type II toxin-antitoxin system death-on-curing family toxin	-
QUF09_RS04145 (KH201010_08000)	888474..888791	-	318	WP_015870279.1	helix-turn-helix transcriptional regulator	Antitoxin
QUF09_RS04150 (KH201010_08010)	888793..889137	-	345	WP_015870280.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
QUF09_RS04155	889309..889527	-	219	WP_232347353.1	head completion/stabilization protein	-
QUF09_RS04160 (KH201010_08030)	889556..890245	+	690	WP_015870281.1	phage portal protein	-
QUF09_RS04165 (KH201010_08050)	891373..892220	-	848	Protein_792	MurR/RpiR family transcriptional regulator	-
QUF09_RS04170 (KH201010_08060)	892421..893020	+	600	WP_286329806.1	phosphatidylglycerophosphatase C	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-105)

Antitoxin

• Cro/C1-type helix-turn-helix domain (34-86)

Sequences

Toxin

Protein

• Length: 115 a.a.
• Molecular weight: 12544.34 Da
• Isoelectric Point: 9.8474

>T44553 WP_015870280.1 NZ_AP028106:c889137-888793 [Edwardsiella ictaluri]
MKSLYWVGSTKKDLQSLPEEVQDIFGYALHLAQVGGKHSQTKPLKGFSGAGVLEVVEDFLGDTYRAVYTVKFGDAVYVSH
VFQKKSSSGIATPKLNMDKIRERLKAAENHARGA

Nucleotide

• Length: 345 bp

>T44553 NZ_AP028106:c889137-888793 [Edwardsiella ictaluri]
ATGAAGTCACTATATTGGGTTGGTAGTACAAAAAAAGACCTCCAGTCATTGCCTGAAGAAGTACAGGATATTTTCGGCTA
TGCCCTGCATCTGGCACAGGTAGGAGGTAAACACTCACAGACCAAGCCACTGAAGGGGTTTAGTGGAGCTGGCGTACTTG
AGGTAGTAGAAGACTTTCTCGGTGATACTTATCGTGCAGTGTATACCGTTAAGTTCGGTGATGCCGTCTACGTTTCGCAC
GTATTCCAGAAAAAGTCTTCATCGGGAATCGCCACGCCAAAGCTCAATATGGACAAGATCCGCGAACGGCTAAAAGCCGC
AGAAAACCATGCCAGAGGAGCATAA

Antitoxin

Protein

• Length: 106 a.a.
• Molecular weight: 11480.41 Da
• Isoelectric Point: 10.2058

>AT44553 WP_015870279.1 NZ_AP028106:c888791-888474 [Edwardsiella ictaluri]
MSHDIEVSSGNVYVDIGRDDAEEMLLKAQLATTIGNIIKSRSLTQEQAAKLLGMTQPKLSNMLRGQFRGISEAKMLECLT
RLGRDVQIVVGKPRRTPGSVKVVLA

Nucleotide

• Length: 318 bp

>AT44553 NZ_AP028106:c888791-888474 [Edwardsiella ictaluri]
ATGAGCCATGATATTGAAGTCAGCAGCGGCAACGTTTATGTCGATATTGGCAGAGATGATGCCGAGGAAATGCTGTTAAA
AGCTCAGCTTGCCACCACTATTGGAAACATCATTAAAAGCCGTAGCCTGACGCAAGAACAAGCAGCAAAACTGCTGGGGA
TGACGCAGCCCAAACTGTCCAATATGCTGCGTGGGCAGTTCCGGGGCATCAGTGAAGCCAAAATGCTGGAATGTCTGACC
CGCTTAGGGCGCGACGTGCAAATCGTGGTTGGAAAGCCGCGCCGGACGCCGGGTAGCGTGAAAGTAGTGTTAGCCTGA

Structures

Toxin

• AlphaFold DB: C5B7U4