Detailed information of TA system TA044551

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3194060..3194723
• Replicon: chromosome
• Accession: NZ_AP028102
• Organism: Edwardsiella ictaluri strain KB20921

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: C5BAS3
• Locus tag: QUF12_RS15075
• Protein ID: WP_015872556.1
• Coordinates: 3194060..3194476 (-)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: C5BAS4
• Locus tag: QUF12_RS15080
• Protein ID: WP_015872557.1
• Coordinates: 3194457..3194723 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QUF12_RS15055 (KB20921_29390)	3189984..3191717	-	1734	WP_015872552.1	single-stranded-DNA-specific exonuclease RecJ	-
QUF12_RS15060 (KB20921_29400)	3191722..3192438	-	717	WP_015872553.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
QUF12_RS15065 (KB20921_29410)	3192466..3193365	-	900	WP_015872554.1	site-specific tyrosine recombinase XerD	-
QUF12_RS15070 (KB20921_29420)	3193523..3194035	+	513	WP_015872555.1	flavodoxin FldB	-
QUF12_RS15075 (KB20921_29430)	3194060..3194476	-	417	WP_015872556.1	protein YgfX	Toxin
QUF12_RS15080 (KB20921_29440)	3194457..3194723	-	267	WP_015872557.1	FAD assembly factor SdhE	Antitoxin
QUF12_RS15085 (KB20921_29450)	3195071..3196066	+	996	WP_015872558.1	tRNA-modifying protein YgfZ	-
QUF12_RS15090 (KB20921_29460)	3196107..3196931	-	825	WP_015872559.1	shikimate 5-dehydrogenase	-
QUF12_RS15095 (KB20921_29470)	3197093..3197965	-	873	WP_015872560.1	nucleoside-specific channel-forming protein Tsx	-
QUF12_RS15100 (KB20921_29480)	3198574..3199224	+	651	WP_035609190.1	hemolysin III family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 16145.89 Da
• Isoelectric Point: 11.3233

>T44551 WP_015872556.1 NZ_AP028102:c3194476-3194060 [Edwardsiella ictaluri]
VALWRCNVHASWRTQVMFLLGHGALVLAILLAPWPENYSVFWLILLVAVIFECIRSQRLIARNSGELQRLAPQVWHWQLR
EWRLARRPWVSDLGALLILQSTHGTPCRRRLWLAADSMSREEWGQLRRALLDTGDDRV

Nucleotide

• Length: 417 bp

>T44551 NZ_AP028102:c3194476-3194060 [Edwardsiella ictaluri]
GTGGCCCTTTGGCGCTGTAATGTTCACGCCTCCTGGCGTACCCAGGTGATGTTTCTGCTGGGGCATGGCGCGCTGGTATT
GGCGATCCTGTTGGCGCCCTGGCCGGAAAACTACAGCGTATTCTGGCTGATTCTGCTGGTTGCGGTGATCTTTGAGTGTA
TCCGCAGCCAGCGTCTGATTGCGCGTAACAGCGGTGAGCTACAGCGGCTGGCCCCACAGGTATGGCACTGGCAGCTGCGC
GAGTGGCGCCTGGCCCGGCGCCCCTGGGTTAGCGATCTGGGAGCGTTGCTGATCCTGCAGAGTACCCATGGCACGCCGTG
CCGCCGTCGTCTGTGGCTGGCGGCCGACAGCATGAGCCGCGAAGAGTGGGGGCAGCTGCGCCGCGCGCTGCTCGATACGG
GCGACGATCGCGTATAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10364.92 Da
• Isoelectric Point: 5.6951

>AT44551 WP_015872557.1 NZ_AP028102:c3194723-3194457 [Edwardsiella ictaluri]
MDINNKARVHWACRRGMRELDIAIMPFFEHEYDALNDADKQTFVRLLSCDDPELFKWLMNQGKPDDTDLARMITLIQTRN
KERGPLAL

Nucleotide

• Length: 267 bp

>AT44551 NZ_AP028102:c3194723-3194457 [Edwardsiella ictaluri]
ATGGATATCAATAATAAAGCGCGGGTTCACTGGGCGTGCCGCCGCGGAATGCGTGAGCTGGATATCGCCATTATGCCTTT
CTTTGAACATGAGTATGATGCGCTTAACGATGCCGATAAACAGACCTTTGTCCGACTGCTGTCCTGTGACGATCCTGAAC
TATTTAAATGGCTGATGAACCAGGGTAAGCCGGACGATACCGATCTGGCCCGTATGATTACGCTGATTCAGACGCGAAAT
AAAGAACGTGGCCCTTTGGCGCTGTAA

Structures

Toxin

• AlphaFold DB: C5BAS3

Antitoxin

• AlphaFold DB: C5BAS4