Detailed information of TA system TA044547

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-DnaT
• Location: 1956624..1957146
• Replicon: chromosome
• Accession: NZ_AP028102
• Organism: Edwardsiella ictaluri strain KB20921

Toxin (Protein)

• Gene name: relE
• Uniprot ID: C5BBL4
• Locus tag: QUF12_RS09220
• Protein ID: WP_015871319.1
• Coordinates: 1956865..1957146 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: C5BBL3
• Locus tag: QUF12_RS09215
• Protein ID: WP_015871318.1
• Coordinates: 1956624..1956875 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QUF12_RS09185 (KB20921_18020)	1951780..1952442	-	663	WP_015871312.1	hypothetical protein	-
QUF12_RS09190 (KB20921_18030)	1952442..1953002	-	561	WP_263115783.1	hypothetical protein	-
QUF12_RS09195 (KB20921_18040)	1953023..1953466	-	444	WP_015871314.1	hypothetical protein	-
QUF12_RS09200 (KB20921_18050)	1953508..1953903	-	396	WP_049640651.1	hypothetical protein	-
QUF12_RS09205 (KB20921_18060)	1954061..1955317	-	1257	WP_198077050.1	N4-gp56 family major capsid protein	-
QUF12_RS09210 (KB20921_18070)	1955335..1956336	-	1002	WP_015871317.1	hypothetical protein	-
QUF12_RS09215 (KB20921_18080)	1956624..1956875	+	252	WP_015871318.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
QUF12_RS09220 (KB20921_18090)	1956865..1957146	+	282	WP_015871319.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
QUF12_RS09225 (KB20921_18100)	1957218..1959332	-	2115	WP_015871320.1	hypothetical protein	-
QUF12_RS09230 (KB20921_18110)	1959329..1960990	-	1662	WP_050977403.1	terminase	-
QUF12_RS09235 (KB20921_18120)	1960983..1961405	-	423	WP_232347283.1	hypothetical protein	-
QUF12_RS09240 (KB20921_18130)	1961540..1961767	-	228	WP_232347284.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1933525..1990701	57176

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-84)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10783.62 Da
• Isoelectric Point: 10.6993

>T44547 WP_015871319.1 NZ_AP028102:1956865-1957146 [Edwardsiella ictaluri]
MTYKLSFEKRALKEWKKLAPPIQSQLKKKLIERLENPHVPAARLSGRANRYKIKLRSSGYRLVYEVNDSEIILLVIAIGK
RADNEVYQAADSR

Nucleotide

• Length: 282 bp

>T44547 NZ_AP028102:1956865-1957146 [Edwardsiella ictaluri]
ATGACCTATAAACTGAGCTTTGAAAAGCGAGCCCTGAAAGAGTGGAAAAAACTGGCACCGCCGATTCAAAGCCAGTTGAA
AAAGAAACTGATCGAACGCCTGGAAAACCCACATGTTCCAGCAGCACGCTTAAGTGGGCGCGCTAACCGTTATAAAATAA
AATTACGCTCTTCCGGTTACCGGTTAGTTTATGAAGTCAACGATAGCGAAATCATCCTGCTGGTGATCGCTATCGGTAAA
CGGGCCGATAACGAGGTGTACCAAGCGGCAGACAGTCGTTAG

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9155.24 Da
• Isoelectric Point: 3.7550

>AT44547 WP_015871318.1 NZ_AP028102:1956624-1956875 [Edwardsiella ictaluri]
MAYQILTTTAASITDLKRNPMGTIAEGDGNAVAILNRNEPAFYCVPPELYAYYLELAEDAALNRIADERLEDAEFVSVNI
DDL

Nucleotide

• Length: 252 bp

>AT44547 NZ_AP028102:1956624-1956875 [Edwardsiella ictaluri]
ATGGCATACCAAATTCTCACGACCACCGCCGCCAGCATTACCGACCTGAAACGCAATCCAATGGGTACCATTGCTGAAGG
TGACGGCAATGCCGTAGCAATCTTAAACCGGAATGAGCCGGCCTTTTACTGCGTTCCACCGGAACTCTACGCTTACTATC
TGGAGCTGGCTGAAGATGCGGCGCTTAATCGTATCGCCGATGAGCGTCTGGAGGACGCTGAGTTTGTCAGCGTAAATATC
GATGACCTATAA

Structures

Toxin

• AlphaFold DB: C5BBL4

Antitoxin

• AlphaFold DB: C5BBL3