44546

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1108907..1109499 Replicon chromosome
Accession NZ_AP028102
Organism Edwardsiella ictaluri strain KB20921

Toxin (Protein)


Gene name Hha Uniprot ID D0ZEC2
Locus tag QUF12_RS05150 Protein ID WP_012847872.1
Coordinates 1108907..1109110 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID C5BCY7
Locus tag QUF12_RS05155 Protein ID WP_015870487.1
Coordinates 1109131..1109499 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QUF12_RS05110 (KB20921_10110) 1104127..1104588 + 462 WP_015870480.1 Lrp/AsnC family transcriptional regulator -
QUF12_RS05115 (KB20921_10120) 1104617..1104784 - 168 WP_015870481.1 hypothetical protein -
QUF12_RS05120 (KB20921_10130) 1104887..1105225 + 339 WP_015870482.1 P-II family nitrogen regulator -
QUF12_RS05125 (KB20921_10140) 1105247..1106527 + 1281 WP_198077273.1 ammonium transporter AmtB -
QUF12_RS05130 (KB20921_10150) 1106561..1107427 - 867 WP_015870484.1 acyl-CoA thioesterase II -
QUF12_RS05135 (KB20921_10160) 1107473..1107802 - 330 WP_015870485.1 MGMT family protein -
QUF12_RS05145 1108780..1108887 + 108 Protein_986 IS5/IS1182 family transposase -
QUF12_RS05150 (KB20921_10180) 1108907..1109110 - 204 WP_012847872.1 HHA domain-containing protein Toxin
QUF12_RS05155 (KB20921_10190) 1109131..1109499 - 369 WP_015870487.1 Hha toxicity modulator TomB Antitoxin
QUF12_RS05160 (KB20921_10200) 1109859..1113011 - 3153 WP_015870488.1 efflux RND transporter permease subunit -
QUF12_RS05165 (KB20921_10210) 1113055..1114239 - 1185 WP_015870489.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-115)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8103.37 Da        Isoelectric Point: 5.0914

>T44546 WP_012847872.1 NZ_AP028102:c1109110-1108907 [Edwardsiella ictaluri]
MTKIDYLMKLRKCTTLDTLERVIEKNKYELSDDELEIFYSAADHRLAELTMNKLYDKIPAEVWQYVR

Download         Length: 204 bp

>T44546 NZ_AP028102:c1109110-1108907 [Edwardsiella ictaluri]
ATGACAAAAATCGATTATCTGATGAAGTTGCGTAAATGCACGACGCTGGATACTCTGGAACGCGTGATCGAAAAGAACAA
ATACGAACTTTCAGATGATGAGCTGGAAATTTTTTATTCTGCCGCAGATCATCGACTGGCTGAATTAACCATGAATAAAC
TATACGACAAAATTCCGGCAGAAGTTTGGCAATACGTCCGCTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14287.03 Da        Isoelectric Point: 5.4786

>AT44546 WP_015870487.1 NZ_AP028102:c1109499-1109131 [Edwardsiella ictaluri]
MDENTSYQHDISELKYLCDYLYHQGIDVLGESNHGWVSDPTAEVNLQLNELIEHIASIAQSFKIKYPRHSDLAEMLDYYL
DETYALFGTYSISETALRQWLRTKRRMAYCLAHEKRNAALHV

Download         Length: 369 bp

>AT44546 NZ_AP028102:c1109499-1109131 [Edwardsiella ictaluri]
ATGGATGAGAACACTTCTTATCAGCATGACATCTCAGAGTTAAAATACCTGTGTGATTACCTGTATCATCAGGGAATAGA
TGTCTTGGGAGAAAGCAATCACGGCTGGGTCAGCGATCCGACGGCAGAAGTAAATCTACAGCTTAACGAGCTGATTGAGC
ATATTGCCAGCATCGCGCAATCATTTAAGATCAAATATCCGCGTCATTCGGATTTAGCCGAAATGCTGGATTATTATCTG
GATGAAACCTATGCCCTGTTTGGCACCTATAGCATAAGTGAAACGGCGCTCAGGCAATGGTTGCGTACCAAACGTCGGAT
GGCATACTGTCTGGCGCATGAAAAGCGCAACGCTGCCTTACATGTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A034SMG4

Antitoxin

Source ID Structure
AlphaFold DB C5BCY7

References