Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tad-ata/COG5606-COG4679 |
| Location | 888482..889145 | Replicon | chromosome |
| Accession | NZ_AP028102 | ||
| Organism | Edwardsiella ictaluri strain KB20921 | ||
Toxin (Protein)
| Gene name | tad | Uniprot ID | C5B7U4 |
| Locus tag | QUF12_RS04140 | Protein ID | WP_015870280.1 |
| Coordinates | 888801..889145 (-) | Length | 115 a.a. |
Antitoxin (Protein)
| Gene name | ata | Uniprot ID | - |
| Locus tag | QUF12_RS04135 | Protein ID | WP_015870279.1 |
| Coordinates | 888482..888799 (-) | Length | 106 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QUF12_RS04090 (KB20921_07940) | 883813..884361 | + | 549 | WP_015870271.1 | YaeQ family protein | - |
| QUF12_RS04095 (KB20921_07950) | 884363..884779 | + | 417 | WP_015870272.1 | alternative ribosome rescue aminoacyl-tRNA hydrolase ArfB | - |
| QUF12_RS04100 (KB20921_07960) | 884876..885553 | + | 678 | WP_015870273.1 | envelope stress response activation lipoprotein NlpE | - |
| QUF12_RS04105 (KB20921_07970) | 885575..885835 | - | 261 | WP_015870274.1 | YfhL family 4Fe-4S dicluster ferredoxin | - |
| QUF12_RS04110 (KB20921_07980) | 886440..886718 | + | 279 | WP_133175613.1 | hypothetical protein | - |
| QUF12_RS04120 (KB20921_08000) | 887663..887842 | + | 180 | WP_071525714.1 | hypothetical protein | - |
| QUF12_RS04125 (KB20921_08010) | 887947..888075 | + | 129 | WP_015870277.1 | hypothetical protein | - |
| QUF12_RS04130 (KB20921_08020) | 888072..888449 | + | 378 | WP_015870278.1 | type II toxin-antitoxin system death-on-curing family toxin | - |
| QUF12_RS04135 (KB20921_08030) | 888482..888799 | - | 318 | WP_015870279.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| QUF12_RS04140 (KB20921_08040) | 888801..889145 | - | 345 | WP_015870280.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| QUF12_RS04145 | 889317..889535 | - | 219 | WP_232347353.1 | head completion/stabilization protein | - |
| QUF12_RS04150 (KB20921_08060) | 889564..890253 | + | 690 | WP_015870281.1 | phage portal protein | - |
| QUF12_RS04155 (KB20921_08080) | 891381..892228 | - | 848 | Protein_790 | MurR/RpiR family transcriptional regulator | - |
| QUF12_RS04160 (KB20921_08090) | 892384..893028 | + | 645 | WP_226092411.1 | phosphatidylglycerophosphatase C | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 115 a.a. Molecular weight: 12544.34 Da Isoelectric Point: 9.8474
>T44545 WP_015870280.1 NZ_AP028102:c889145-888801 [Edwardsiella ictaluri]
MKSLYWVGSTKKDLQSLPEEVQDIFGYALHLAQVGGKHSQTKPLKGFSGAGVLEVVEDFLGDTYRAVYTVKFGDAVYVSH
VFQKKSSSGIATPKLNMDKIRERLKAAENHARGA
MKSLYWVGSTKKDLQSLPEEVQDIFGYALHLAQVGGKHSQTKPLKGFSGAGVLEVVEDFLGDTYRAVYTVKFGDAVYVSH
VFQKKSSSGIATPKLNMDKIRERLKAAENHARGA
Download Length: 345 bp
>T44545 NZ_AP028102:c889145-888801 [Edwardsiella ictaluri]
ATGAAGTCACTATATTGGGTTGGTAGTACAAAAAAAGACCTCCAGTCATTGCCTGAAGAAGTACAGGATATTTTCGGCTA
TGCCCTGCATCTGGCACAGGTAGGAGGTAAACACTCACAGACCAAGCCACTGAAGGGGTTTAGTGGAGCTGGCGTACTTG
AGGTAGTAGAAGACTTTCTCGGTGATACTTATCGTGCAGTGTATACCGTTAAGTTCGGTGATGCCGTCTACGTTTCGCAC
GTATTCCAGAAAAAGTCTTCATCGGGAATCGCCACGCCAAAGCTCAATATGGACAAGATCCGCGAACGGCTAAAAGCCGC
AGAAAACCATGCCAGAGGAGCATAA
ATGAAGTCACTATATTGGGTTGGTAGTACAAAAAAAGACCTCCAGTCATTGCCTGAAGAAGTACAGGATATTTTCGGCTA
TGCCCTGCATCTGGCACAGGTAGGAGGTAAACACTCACAGACCAAGCCACTGAAGGGGTTTAGTGGAGCTGGCGTACTTG
AGGTAGTAGAAGACTTTCTCGGTGATACTTATCGTGCAGTGTATACCGTTAAGTTCGGTGATGCCGTCTACGTTTCGCAC
GTATTCCAGAAAAAGTCTTCATCGGGAATCGCCACGCCAAAGCTCAATATGGACAAGATCCGCGAACGGCTAAAAGCCGC
AGAAAACCATGCCAGAGGAGCATAA
Antitoxin
Download Length: 106 a.a. Molecular weight: 11480.41 Da Isoelectric Point: 10.2058
>AT44545 WP_015870279.1 NZ_AP028102:c888799-888482 [Edwardsiella ictaluri]
MSHDIEVSSGNVYVDIGRDDAEEMLLKAQLATTIGNIIKSRSLTQEQAAKLLGMTQPKLSNMLRGQFRGISEAKMLECLT
RLGRDVQIVVGKPRRTPGSVKVVLA
MSHDIEVSSGNVYVDIGRDDAEEMLLKAQLATTIGNIIKSRSLTQEQAAKLLGMTQPKLSNMLRGQFRGISEAKMLECLT
RLGRDVQIVVGKPRRTPGSVKVVLA
Download Length: 318 bp
>AT44545 NZ_AP028102:c888799-888482 [Edwardsiella ictaluri]
ATGAGCCATGATATTGAAGTCAGCAGCGGCAACGTTTATGTCGATATTGGCAGAGATGATGCCGAGGAAATGCTGTTAAA
AGCTCAGCTTGCCACCACTATTGGAAACATCATTAAAAGCCGTAGCCTGACGCAAGAACAAGCAGCAAAACTGCTGGGGA
TGACGCAGCCCAAACTGTCCAATATGCTGCGTGGGCAGTTCCGGGGCATCAGTGAAGCCAAAATGCTGGAATGTCTGACC
CGCTTAGGGCGCGACGTGCAAATCGTGGTTGGAAAGCCGCGCCGGACGCCGGGTAGCGTGAAAGTAGTGTTAGCCTGA
ATGAGCCATGATATTGAAGTCAGCAGCGGCAACGTTTATGTCGATATTGGCAGAGATGATGCCGAGGAAATGCTGTTAAA
AGCTCAGCTTGCCACCACTATTGGAAACATCATTAAAAGCCGTAGCCTGACGCAAGAACAAGCAGCAAAACTGCTGGGGA
TGACGCAGCCCAAACTGTCCAATATGCTGCGTGGGCAGTTCCGGGGCATCAGTGAAGCCAAAATGCTGGAATGTCTGACC
CGCTTAGGGCGCGACGTGCAAATCGTGGTTGGAAAGCCGCGCCGGACGCCGGGTAGCGTGAAAGTAGTGTTAGCCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|