Detailed information of TA system TA044543

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3160788..3161451
• Replicon: chromosome
• Accession: NZ_AP028097
• Organism: Edwardsiella ictaluri strain KH20906

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: C5BAS3
• Locus tag: QUE95_RS14970
• Protein ID: WP_015872556.1
• Coordinates: 3160788..3161204 (-)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: C5BAS4
• Locus tag: QUE95_RS14975
• Protein ID: WP_015872557.1
• Coordinates: 3161185..3161451 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QUE95_RS14950 (KH20906_29280)	3156712..3158445	-	1734	WP_015872552.1	single-stranded-DNA-specific exonuclease RecJ	-
QUE95_RS14955 (KH20906_29290)	3158450..3159166	-	717	WP_015872553.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
QUE95_RS14960 (KH20906_29300)	3159194..3160093	-	900	WP_015872554.1	site-specific tyrosine recombinase XerD	-
QUE95_RS14965 (KH20906_29310)	3160251..3160763	+	513	WP_015872555.1	flavodoxin FldB	-
QUE95_RS14970 (KH20906_29320)	3160788..3161204	-	417	WP_015872556.1	protein YgfX	Toxin
QUE95_RS14975 (KH20906_29330)	3161185..3161451	-	267	WP_015872557.1	FAD assembly factor SdhE	Antitoxin
QUE95_RS14980 (KH20906_29340)	3161799..3162794	+	996	WP_015872558.1	tRNA-modifying protein YgfZ	-
QUE95_RS14985 (KH20906_29350)	3162835..3163659	-	825	WP_015872559.1	shikimate 5-dehydrogenase	-
QUE95_RS14990 (KH20906_29360)	3163821..3164693	-	873	WP_015872560.1	nucleoside-specific channel-forming protein Tsx	-
QUE95_RS14995 (KH20906_29370)	3165302..3165952	+	651	WP_035609190.1	hemolysin III family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 16145.89 Da
• Isoelectric Point: 11.3233

>T44543 WP_015872556.1 NZ_AP028097:c3161204-3160788 [Edwardsiella ictaluri]
VALWRCNVHASWRTQVMFLLGHGALVLAILLAPWPENYSVFWLILLVAVIFECIRSQRLIARNSGELQRLAPQVWHWQLR
EWRLARRPWVSDLGALLILQSTHGTPCRRRLWLAADSMSREEWGQLRRALLDTGDDRV

Nucleotide

• Length: 417 bp

>T44543 NZ_AP028097:c3161204-3160788 [Edwardsiella ictaluri]
GTGGCCCTTTGGCGCTGTAATGTTCACGCCTCCTGGCGTACCCAGGTGATGTTTCTGCTGGGGCATGGCGCGCTGGTATT
GGCGATCCTGTTGGCGCCCTGGCCGGAAAACTACAGCGTATTCTGGCTGATTCTGCTGGTTGCGGTGATCTTTGAGTGTA
TCCGCAGCCAGCGTCTGATTGCGCGTAACAGCGGTGAGCTACAGCGGCTGGCCCCACAGGTATGGCACTGGCAGCTGCGC
GAGTGGCGCCTGGCCCGGCGCCCCTGGGTTAGCGATCTGGGAGCGTTGCTGATCCTGCAGAGTACCCATGGCACGCCGTG
CCGCCGTCGTCTGTGGCTGGCGGCCGACAGCATGAGCCGCGAAGAGTGGGGGCAGCTGCGCCGCGCGCTGCTCGATACGG
GCGACGATCGCGTATAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10364.92 Da
• Isoelectric Point: 5.6951

>AT44543 WP_015872557.1 NZ_AP028097:c3161451-3161185 [Edwardsiella ictaluri]
MDINNKARVHWACRRGMRELDIAIMPFFEHEYDALNDADKQTFVRLLSCDDPELFKWLMNQGKPDDTDLARMITLIQTRN
KERGPLAL

Nucleotide

• Length: 267 bp

>AT44543 NZ_AP028097:c3161451-3161185 [Edwardsiella ictaluri]
ATGGATATCAATAATAAAGCGCGGGTTCACTGGGCGTGCCGCCGCGGAATGCGTGAGCTGGATATCGCCATTATGCCTTT
CTTTGAACATGAGTATGATGCGCTTAACGATGCCGATAAACAGACCTTTGTCCGACTGCTGTCCTGTGACGATCCTGAAC
TATTTAAATGGCTGATGAACCAGGGTAAGCCGGACGATACCGATCTGGCCCGTATGATTACGCTGATTCAGACGCGAAAT
AAAGAACGTGGCCCTTTGGCGCTGTAA

Structures

Toxin

• AlphaFold DB: C5BAS3

Antitoxin

• AlphaFold DB: C5BAS4