Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1075659..1076251 Replicon chromosome
Accession NZ_AP028097
Organism Edwardsiella ictaluri strain KH20906

Toxin (Protein)


Gene name Hha Uniprot ID D0ZEC2
Locus tag QUE95_RS05025 Protein ID WP_012847872.1
Coordinates 1075659..1075862 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID C5BCY7
Locus tag QUE95_RS05030 Protein ID WP_015870487.1
Coordinates 1075883..1076251 (-) Length 123 a.a.

Genomic Context

QUE95_RS04985QUE95_RS04995QUE95_RS05000QUE95_RS05020QUE95_RS04990QUE95_RS05005QUE95_RS05010QUE95_RS05025QUE95_RS05030QUE95_RS05035QUE95_RS05040
Location: 1070879..1071340 (462 bp)
Type: Others
Protein ID: WP_015870480.1
Location: 1071639..1071977 (339 bp)
Type: Others
Protein ID: WP_015870482.1
Location: 1071999..1073279 (1281 bp)
Type: Others
Protein ID: WP_198077273.1
Location: 1075532..1075639 (108 bp)
Type: Others
Protein ID: Protein_961
Location: 1071369..1071536 (168 bp)
Type: Others
Protein ID: WP_015870481.1
Location: 1073313..1074179 (867 bp)
Type: Others
Protein ID: WP_015870484.1
Location: 1074225..1074554 (330 bp)
Type: Others
Protein ID: WP_015870485.1
Location: 1075659..1075862 (204 bp)
Type: Toxin
Protein ID: WP_012847872.1
Location: 1075883..1076251 (369 bp)
Type: Antitoxin
Protein ID: WP_015870487.1
Location: 1076611..1079763 (3153 bp)
Type: Others
Protein ID: WP_015870488.1
Location: 1079807..1080991 (1185 bp)
Type: Others
Protein ID: WP_015870489.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
QUE95_RS04985 (KH20906_09760)1070879..1071340+462WP_015870480.1Lrp/AsnC family transcriptional regulator-
QUE95_RS04990 (KH20906_09770)1071369..1071536-168WP_015870481.1hypothetical protein-
QUE95_RS04995 (KH20906_09780)1071639..1071977+339WP_015870482.1P-II family nitrogen regulator-
QUE95_RS05000 (KH20906_09790)1071999..1073279+1281WP_198077273.1ammonium transporter AmtB-
QUE95_RS05005 (KH20906_09800)1073313..1074179-867WP_015870484.1acyl-CoA thioesterase II-
QUE95_RS05010 (KH20906_09810)1074225..1074554-330WP_015870485.1MGMT family protein-
QUE95_RS050201075532..1075639+108Protein_961IS5/IS1182 family transposase-
QUE95_RS05025 (KH20906_09830)1075659..1075862-204WP_012847872.1HHA domain-containing proteinToxin
QUE95_RS05030 (KH20906_09840)1075883..1076251-369WP_015870487.1Hha toxicity modulator TomBAntitoxin
QUE95_RS05035 (KH20906_09850)1076611..1079763-3153WP_015870488.1efflux RND transporter permease subunit-
QUE95_RS05040 (KH20906_09860)1079807..1080991-1185WP_015870489.1efflux RND transporter periplasmic adaptor subunit-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-115)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8103.37 Da        Isoelectric Point: 5.0914

>T44538 WP_012847872.1 NZ_AP028097:c1075862-1075659 [Edwardsiella ictaluri]
MTKIDYLMKLRKCTTLDTLERVIEKNKYELSDDELEIFYSAADHRLAELTMNKLYDKIPAEVWQYVR

Download         Length: 204 bp

>T44538 NZ_AP028097:c1075862-1075659 [Edwardsiella ictaluri]
ATGACAAAAATCGATTATCTGATGAAGTTGCGTAAATGCACGACGCTGGATACTCTGGAACGCGTGATCGAAAAGAACAA
ATACGAACTTTCAGATGATGAGCTGGAAATTTTTTATTCTGCCGCAGATCATCGACTGGCTGAATTAACCATGAATAAAC
TATACGACAAAATTCCGGCAGAAGTTTGGCAATACGTCCGCTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14287.03 Da        Isoelectric Point: 5.4786

>AT44538 WP_015870487.1 NZ_AP028097:c1076251-1075883 [Edwardsiella ictaluri]
MDENTSYQHDISELKYLCDYLYHQGIDVLGESNHGWVSDPTAEVNLQLNELIEHIASIAQSFKIKYPRHSDLAEMLDYYL
DETYALFGTYSISETALRQWLRTKRRMAYCLAHEKRNAALHV

Download         Length: 369 bp

>AT44538 NZ_AP028097:c1076251-1075883 [Edwardsiella ictaluri]
ATGGATGAGAACACTTCTTATCAGCATGACATCTCAGAGTTAAAATACCTGTGTGATTACCTGTATCATCAGGGAATAGA
TGTCTTGGGAGAAAGCAATCACGGCTGGGTCAGCGATCCGACGGCAGAAGTAAATCTACAGCTTAACGAGCTGATTGAGC
ATATTGCCAGCATCGCGCAATCATTTAAGATCAAATATCCGCGTCATTCGGATTTAGCCGAAATGCTGGATTATTATCTG
GATGAAACCTATGCCCTGTTTGGCACCTATAGCATAAGTGAAACGGCGCTCAGGCAATGGTTGCGTACCAAACGTCGGAT
GGCATACTGTCTGGCGCATGAAAAGCGCAACGCTGCCTTACATGTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A034SMG4

Antitoxin

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Source
ID
Structure
AlphaFold DBC5BCY7

References