Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1075659..1076251 Replicon chromosome
Accession NZ_AP028097
Organism Edwardsiella ictaluri strain KH20906

Toxin (Protein)


Gene name Hha Uniprot ID D0ZEC2
Locus tag QUE95_RS05025 Protein ID WP_012847872.1
Coordinates 1075659..1075862 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID C5BCY7
Locus tag QUE95_RS05030 Protein ID WP_015870487.1
Coordinates 1075883..1076251 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QUE95_RS04985 (KH20906_09760) 1070879..1071340 + 462 WP_015870480.1 Lrp/AsnC family transcriptional regulator -
QUE95_RS04990 (KH20906_09770) 1071369..1071536 - 168 WP_015870481.1 hypothetical protein -
QUE95_RS04995 (KH20906_09780) 1071639..1071977 + 339 WP_015870482.1 P-II family nitrogen regulator -
QUE95_RS05000 (KH20906_09790) 1071999..1073279 + 1281 WP_198077273.1 ammonium transporter AmtB -
QUE95_RS05005 (KH20906_09800) 1073313..1074179 - 867 WP_015870484.1 acyl-CoA thioesterase II -
QUE95_RS05010 (KH20906_09810) 1074225..1074554 - 330 WP_015870485.1 MGMT family protein -
QUE95_RS05020 1075532..1075639 + 108 Protein_961 IS5/IS1182 family transposase -
QUE95_RS05025 (KH20906_09830) 1075659..1075862 - 204 WP_012847872.1 HHA domain-containing protein Toxin
QUE95_RS05030 (KH20906_09840) 1075883..1076251 - 369 WP_015870487.1 Hha toxicity modulator TomB Antitoxin
QUE95_RS05035 (KH20906_09850) 1076611..1079763 - 3153 WP_015870488.1 efflux RND transporter permease subunit -
QUE95_RS05040 (KH20906_09860) 1079807..1080991 - 1185 WP_015870489.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-115)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8103.37 Da        Isoelectric Point: 5.0914

>T44538 WP_012847872.1 NZ_AP028097:c1075862-1075659 [Edwardsiella ictaluri]
MTKIDYLMKLRKCTTLDTLERVIEKNKYELSDDELEIFYSAADHRLAELTMNKLYDKIPAEVWQYVR

Download         Length: 204 bp

>T44538 NZ_AP028097:c1075862-1075659 [Edwardsiella ictaluri]
ATGACAAAAATCGATTATCTGATGAAGTTGCGTAAATGCACGACGCTGGATACTCTGGAACGCGTGATCGAAAAGAACAA
ATACGAACTTTCAGATGATGAGCTGGAAATTTTTTATTCTGCCGCAGATCATCGACTGGCTGAATTAACCATGAATAAAC
TATACGACAAAATTCCGGCAGAAGTTTGGCAATACGTCCGCTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14287.03 Da        Isoelectric Point: 5.4786

>AT44538 WP_015870487.1 NZ_AP028097:c1076251-1075883 [Edwardsiella ictaluri]
MDENTSYQHDISELKYLCDYLYHQGIDVLGESNHGWVSDPTAEVNLQLNELIEHIASIAQSFKIKYPRHSDLAEMLDYYL
DETYALFGTYSISETALRQWLRTKRRMAYCLAHEKRNAALHV

Download         Length: 369 bp

>AT44538 NZ_AP028097:c1076251-1075883 [Edwardsiella ictaluri]
ATGGATGAGAACACTTCTTATCAGCATGACATCTCAGAGTTAAAATACCTGTGTGATTACCTGTATCATCAGGGAATAGA
TGTCTTGGGAGAAAGCAATCACGGCTGGGTCAGCGATCCGACGGCAGAAGTAAATCTACAGCTTAACGAGCTGATTGAGC
ATATTGCCAGCATCGCGCAATCATTTAAGATCAAATATCCGCGTCATTCGGATTTAGCCGAAATGCTGGATTATTATCTG
GATGAAACCTATGCCCTGTTTGGCACCTATAGCATAAGTGAAACGGCGCTCAGGCAATGGTTGCGTACCAAACGTCGGAT
GGCATACTGTCTGGCGCATGAAAAGCGCAACGCTGCCTTACATGTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A034SMG4

Antitoxin

Source ID Structure
AlphaFold DB C5BCY7

References