Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tad-ata/COG5606-COG4679 |
| Location | 888471..889134 | Replicon | chromosome |
| Accession | NZ_AP028097 | ||
| Organism | Edwardsiella ictaluri strain KH20906 | ||
Toxin (Protein)
| Gene name | tad | Uniprot ID | C5B7U4 |
| Locus tag | QUE95_RS04145 | Protein ID | WP_015870280.1 |
| Coordinates | 888790..889134 (-) | Length | 115 a.a. |
Antitoxin (Protein)
| Gene name | ata | Uniprot ID | - |
| Locus tag | QUE95_RS04140 | Protein ID | WP_015870279.1 |
| Coordinates | 888471..888788 (-) | Length | 106 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QUE95_RS04095 (KH20906_07920) | 883802..884350 | + | 549 | WP_015870271.1 | YaeQ family protein | - |
| QUE95_RS04100 (KH20906_07930) | 884352..884768 | + | 417 | WP_015870272.1 | alternative ribosome rescue aminoacyl-tRNA hydrolase ArfB | - |
| QUE95_RS04105 (KH20906_07940) | 884865..885542 | + | 678 | WP_015870273.1 | envelope stress response activation lipoprotein NlpE | - |
| QUE95_RS04110 (KH20906_07950) | 885564..885824 | - | 261 | WP_015870274.1 | YfhL family 4Fe-4S dicluster ferredoxin | - |
| QUE95_RS04115 (KH20906_07960) | 886429..886707 | + | 279 | WP_133175613.1 | hypothetical protein | - |
| QUE95_RS04125 (KH20906_07980) | 887652..887831 | + | 180 | WP_071525714.1 | hypothetical protein | - |
| QUE95_RS04130 (KH20906_07990) | 887936..888064 | + | 129 | WP_015870277.1 | hypothetical protein | - |
| QUE95_RS04135 (KH20906_08000) | 888061..888438 | + | 378 | WP_015870278.1 | type II toxin-antitoxin system death-on-curing family toxin | - |
| QUE95_RS04140 (KH20906_08010) | 888471..888788 | - | 318 | WP_015870279.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| QUE95_RS04145 (KH20906_08020) | 888790..889134 | - | 345 | WP_015870280.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| QUE95_RS04150 | 889306..889524 | - | 219 | WP_232347353.1 | head completion/stabilization protein | - |
| QUE95_RS04155 (KH20906_08040) | 889553..890242 | + | 690 | WP_015870281.1 | phage portal protein | - |
| QUE95_RS04160 (KH20906_08060) | 891370..892217 | - | 848 | Protein_791 | MurR/RpiR family transcriptional regulator | - |
| QUE95_RS04165 (KH20906_08070) | 892373..893017 | + | 645 | WP_226092411.1 | phosphatidylglycerophosphatase C | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 115 a.a. Molecular weight: 12544.34 Da Isoelectric Point: 9.8474
>T44537 WP_015870280.1 NZ_AP028097:c889134-888790 [Edwardsiella ictaluri]
MKSLYWVGSTKKDLQSLPEEVQDIFGYALHLAQVGGKHSQTKPLKGFSGAGVLEVVEDFLGDTYRAVYTVKFGDAVYVSH
VFQKKSSSGIATPKLNMDKIRERLKAAENHARGA
MKSLYWVGSTKKDLQSLPEEVQDIFGYALHLAQVGGKHSQTKPLKGFSGAGVLEVVEDFLGDTYRAVYTVKFGDAVYVSH
VFQKKSSSGIATPKLNMDKIRERLKAAENHARGA
Download Length: 345 bp
>T44537 NZ_AP028097:c889134-888790 [Edwardsiella ictaluri]
ATGAAGTCACTATATTGGGTTGGTAGTACAAAAAAAGACCTCCAGTCATTGCCTGAAGAAGTACAGGATATTTTCGGCTA
TGCCCTGCATCTGGCACAGGTAGGAGGTAAACACTCACAGACCAAGCCACTGAAGGGGTTTAGTGGAGCTGGCGTACTTG
AGGTAGTAGAAGACTTTCTCGGTGATACTTATCGTGCAGTGTATACCGTTAAGTTCGGTGATGCCGTCTACGTTTCGCAC
GTATTCCAGAAAAAGTCTTCATCGGGAATCGCCACGCCAAAGCTCAATATGGACAAGATCCGCGAACGGCTAAAAGCCGC
AGAAAACCATGCCAGAGGAGCATAA
ATGAAGTCACTATATTGGGTTGGTAGTACAAAAAAAGACCTCCAGTCATTGCCTGAAGAAGTACAGGATATTTTCGGCTA
TGCCCTGCATCTGGCACAGGTAGGAGGTAAACACTCACAGACCAAGCCACTGAAGGGGTTTAGTGGAGCTGGCGTACTTG
AGGTAGTAGAAGACTTTCTCGGTGATACTTATCGTGCAGTGTATACCGTTAAGTTCGGTGATGCCGTCTACGTTTCGCAC
GTATTCCAGAAAAAGTCTTCATCGGGAATCGCCACGCCAAAGCTCAATATGGACAAGATCCGCGAACGGCTAAAAGCCGC
AGAAAACCATGCCAGAGGAGCATAA
Antitoxin
Download Length: 106 a.a. Molecular weight: 11480.41 Da Isoelectric Point: 10.2058
>AT44537 WP_015870279.1 NZ_AP028097:c888788-888471 [Edwardsiella ictaluri]
MSHDIEVSSGNVYVDIGRDDAEEMLLKAQLATTIGNIIKSRSLTQEQAAKLLGMTQPKLSNMLRGQFRGISEAKMLECLT
RLGRDVQIVVGKPRRTPGSVKVVLA
MSHDIEVSSGNVYVDIGRDDAEEMLLKAQLATTIGNIIKSRSLTQEQAAKLLGMTQPKLSNMLRGQFRGISEAKMLECLT
RLGRDVQIVVGKPRRTPGSVKVVLA
Download Length: 318 bp
>AT44537 NZ_AP028097:c888788-888471 [Edwardsiella ictaluri]
ATGAGCCATGATATTGAAGTCAGCAGCGGCAACGTTTATGTCGATATTGGCAGAGATGATGCCGAGGAAATGCTGTTAAA
AGCTCAGCTTGCCACCACTATTGGAAACATCATTAAAAGCCGTAGCCTGACGCAAGAACAAGCAGCAAAACTGCTGGGGA
TGACGCAGCCCAAACTGTCCAATATGCTGCGTGGGCAGTTCCGGGGCATCAGTGAAGCCAAAATGCTGGAATGTCTGACC
CGCTTAGGGCGCGACGTGCAAATCGTGGTTGGAAAGCCGCGCCGGACGCCGGGTAGCGTGAAAGTAGTGTTAGCCTGA
ATGAGCCATGATATTGAAGTCAGCAGCGGCAACGTTTATGTCGATATTGGCAGAGATGATGCCGAGGAAATGCTGTTAAA
AGCTCAGCTTGCCACCACTATTGGAAACATCATTAAAAGCCGTAGCCTGACGCAAGAACAAGCAGCAAAACTGCTGGGGA
TGACGCAGCCCAAACTGTCCAATATGCTGCGTGGGCAGTTCCGGGGCATCAGTGAAGCCAAAATGCTGGAATGTCTGACC
CGCTTAGGGCGCGACGTGCAAATCGTGGTTGGAAAGCCGCGCCGGACGCCGGGTAGCGTGAAAGTAGTGTTAGCCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|