Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3458725..3459379 Replicon chromosome
Accession NZ_AP028094
Organism Escherichia coli strain JNE132847

Toxin (Protein)


Gene name cptA Uniprot ID F4NJ21
Locus tag JE76HU_RS17575 Protein ID WP_000244772.1
Coordinates 3458725..3459132 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag JE76HU_RS17580 Protein ID WP_000354046.1
Coordinates 3459113..3459379 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JE76HU_RS17555 (3454682) 3454682..3456415 - 1734 WP_024215392.1 single-stranded-DNA-specific exonuclease RecJ -
JE76HU_RS17560 (3456421) 3456421..3457131 - 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
JE76HU_RS17565 (3457156) 3457156..3458052 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
JE76HU_RS17570 (3458164) 3458164..3458685 + 522 WP_001055874.1 flavodoxin FldB -
JE76HU_RS17575 (3458725) 3458725..3459132 - 408 WP_000244772.1 protein YgfX Toxin
JE76HU_RS17580 (3459113) 3459113..3459379 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
JE76HU_RS17585 (3459622) 3459622..3460602 + 981 WP_000886062.1 tRNA-modifying protein YgfZ -
JE76HU_RS17590 (3460798) 3460798..3461457 - 660 WP_000250274.1 hemolysin III family protein -
JE76HU_RS17595 (3461621) 3461621..3461932 - 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
JE76HU_RS17600 (3461977) 3461977..3463410 + 1434 WP_001307385.1 6-phospho-beta-glucosidase BglA -
JE76HU_RS17605 (3463467) 3463467..3464210 - 744 WP_000951964.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16048.02 Da        Isoelectric Point: 11.2511

>T44518 WP_000244772.1 NZ_AP028094:c3459132-3458725 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWCIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T44518 NZ_AP028094:c3459132-3458725 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGTGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT44518 WP_000354046.1 NZ_AP028094:c3459379-3459113 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT44518 NZ_AP028094:c3459379-3459113 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XYB4

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References