Detailed information of TA system TA044499

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): paaR-paaA-parE/-
• Location: 1107034..1107512
• Replicon: chromosome
• Accession: NZ_AP028094
• Organism: Escherichia coli strain JNE132847

Toxin (Protein)

• Gene name: parE_1
• Uniprot ID: A0A891SFN9
• Locus tag: JE76HU_RS05300
• Protein ID: WP_001303876.1
• Coordinates: 1107034..1107321 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: paaA
• Uniprot ID: Q8XD67
• Locus tag: JE76HU_RS05305
• Protein ID: WP_000536233.1
• Coordinates: 1107321..1107512 (-)
• Length: 64 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JE76HU_RS05265 (1102220)	1102220..1104655	-	2436	WP_104951234.1	exonuclease	-
JE76HU_RS05270 (1104749)	1104749..1104940	-	192	WP_001098307.1	DUF1482 family protein	-
JE76HU_RS05275 (1104937)	1104937..1105125	-	189	WP_000413705.1	cell division inhibition protein DicB	-
JE76HU_RS05280 (1105699)	1105699..1105884	+	186	WP_024215602.1	hypothetical protein	-
JE76HU_RS05285 (1106071)	1106071..1106460	-	390	WP_000394511.1	hypothetical protein	-
JE76HU_RS05290 (1106472)	1106472..1106600	-	129	WP_000344963.1	protein YdfB	-
JE76HU_RS05295 (1106602)	1106602..1106757	-	156	WP_000379575.1	DUF1391 family protein	-
JE76HU_RS05300 (1107034)	1107034..1107321	-	288	WP_001303876.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JE76HU_RS05305 (1107321)	1107321..1107512	-	192	WP_000536233.1	hypothetical protein	Antitoxin
JE76HU_RS05310 (1107540)	1107540..1107941	-	402	WP_000986592.1	helix-turn-helix domain-containing protein	-
JE76HU_RS05315 (1108050)	1108050..1108322	+	273	WP_000887453.1	YdaS family helix-turn-helix protein	-
JE76HU_RS05320 (1108306)	1108306..1108731	+	426	WP_000693855.1	toxin YdaT family protein	-
JE76HU_RS05325 (1108938)	1108938..1109393	-	456	WP_000273724.1	hypothetical protein	-
JE76HU_RS05330 (1109472)	1109472..1110587	+	1116	WP_001205820.1	hypothetical protein	-
JE76HU_RS05335 (1110594)	1110594..1111340	+	747	WP_000788751.1	ATP-binding protein	-
JE76HU_RS05340 (1111362)	1111362..1112132	+	771	WP_024215598.1	DUF1627 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10978.84 Da
• Isoelectric Point: 10.1360

>T44499 WP_001303876.1 NZ_AP028094:c1107321-1107034 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Nucleotide

• Length: 288 bp

>T44499 NZ_AP028094:c1107321-1107034 [Escherichia coli]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin

Protein

• Length: 64 a.a.
• Molecular weight: 7025.80 Da
• Isoelectric Point: 4.0270

>AT44499 WP_000536233.1 NZ_AP028094:c1107512-1107321 [Escherichia coli]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Nucleotide

• Length: 192 bp

>AT44499 NZ_AP028094:c1107512-1107321 [Escherichia coli]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA