Detailed information of TA system TA044468

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-YefM
• Location: 2681656..2682218
• Replicon: chromosome
• Accession: NZ_AP028067
• Organism: Vibrio sp. FE10

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: QUF19_RS11915
• Protein ID: WP_171762948.1
• Coordinates: 2681656..2681958 (-)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A4U2D9I2
• Locus tag: QUF19_RS11920
• Protein ID: WP_016799688.1
• Coordinates: 2681958..2682218 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QUF19_RS11895	2677275..2678425	+	1151	Protein_2289	IS3 family transposase	-
QUF19_RS11900	2678724..2680391	+	1668	WP_171762950.1	Eco57I restriction-modification methylase domain-containing protein	-
QUF19_RS11905	2680392..2681111	+	720	WP_171762949.1	PaeR7I family type II restriction endonuclease	-
QUF19_RS11910	2681141..2681314	-	174	Protein_2292	regulator	-
QUF19_RS11915	2681656..2681958	-	303	WP_171762948.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
QUF19_RS11920	2681958..2682218	-	261	WP_016799688.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
QUF19_RS11925	2682436..2682975	+	540	WP_286293922.1	recombinase family protein	-
QUF19_RS11930	2683054..2683224	+	171	WP_286293924.1	acetyltransferase	-
QUF19_RS11935	2683224..2683622	+	399	WP_286298880.1	type II toxin-antitoxin system death-on-curing family toxin	-
QUF19_RS11940	2683804..2684757	-	954	WP_286293925.1	hypothetical protein	-
QUF19_RS11945	2684971..2686503	+	1533	WP_286291968.1	IS21 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2633542..2692737	59195

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-89)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-64)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11817.63 Da
• Isoelectric Point: 9.8849

>T44468 WP_171762948.1 NZ_AP028067:c2681958-2681656 [Vibrio sp. FE10]
MTHYKLSSSAQSDLIEIRRYTLERWGQAQWTTYFSELKQSMELLANNKLLGIEVSEVGQNYFRFPLKRHVIYYIQKQDHI
IIAAVLGKHMSPAKHFSQRC

Nucleotide

• Length: 303 bp

>T44468 NZ_AP028067:c2681958-2681656 [Vibrio sp. FE10]
ATGACGCACTATAAGCTCTCTTCTTCAGCGCAATCTGATCTGATTGAGATTCGTCGCTATACATTAGAGCGATGGGGGCA
AGCACAATGGACTACTTACTTTTCAGAACTAAAGCAATCAATGGAATTACTGGCGAACAACAAGTTGCTCGGCATAGAGG
TTTCTGAGGTGGGCCAAAACTACTTCCGTTTTCCTTTAAAGCGCCATGTGATTTATTACATCCAGAAACAAGATCACATA
ATTATTGCAGCCGTTCTTGGTAAGCACATGTCTCCGGCCAAGCACTTTTCACAACGGTGTTAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9616.02 Da
• Isoelectric Point: 4.4230

>AT44468 WP_016799688.1 NZ_AP028067:c2682218-2681958 [Vibrio sp. FE10]
MQSLTANTAKTKFGDLLMKVQREPIQINKNGSPVAVMMSCEEYEQLEALKLMVVKSRFEQAEADALSDKLVDGDDFMNAL
NQGKFD

Nucleotide

• Length: 261 bp

>AT44468 NZ_AP028067:c2682218-2681958 [Vibrio sp. FE10]
ATGCAATCACTTACTGCGAATACAGCTAAAACCAAATTTGGCGACTTACTGATGAAAGTTCAACGTGAACCTATACAAAT
TAATAAGAATGGTTCACCCGTTGCGGTGATGATGTCTTGTGAAGAATATGAACAACTTGAAGCACTGAAATTGATGGTGG
TGAAATCACGCTTCGAACAAGCAGAAGCCGATGCTCTATCAGATAAACTAGTCGACGGTGACGATTTCATGAATGCACTT
AACCAAGGAAAGTTTGATTAA

Structures

Antitoxin

• AlphaFold DB: A0A4U2D9I2