Detailed information of TA system TA044461

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 2325755..2326911
• Replicon: chromosome
• Accession: NZ_AP028062
• Organism: Marinobacter shengliensis strain D49

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: QUE75_RS10685
• Protein ID: WP_286249961.1
• Coordinates: 2326117..2326911 (+)
• Length: 265 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A137S3F5
• Locus tag: QUE75_RS10680
• Protein ID: WP_061333408.1
• Coordinates: 2325755..2326120 (+)
• Length: 122 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QUE75_RS10665 (MAALD49_21190)	2320914..2322518	+	1605	WP_286249954.1	FAD-binding oxidoreductase	-
QUE75_RS10670 (MAALD49_21200)	2322526..2324112	+	1587	WP_286249956.1	glycerol-3-phosphate dehydrogenase/oxidase	-
QUE75_RS10675 (MAALD49_21210)	2324118..2325677	+	1560	WP_286249958.1	FGGY-family carbohydrate kinase	-
QUE75_RS10680 (MAALD49_21220)	2325755..2326120	+	366	WP_061333408.1	MbcA/ParS/Xre antitoxin family protein	Antitoxin
QUE75_RS10685 (MAALD49_21230)	2326117..2326911	+	795	WP_286249961.1	RES family NAD+ phosphorylase	Toxin
QUE75_RS10690 (MAALD49_21240)	2326889..2328301	-	1413	WP_286249963.1	efflux transporter outer membrane subunit	-
QUE75_RS10695 (MAALD49_21250)	2328306..2330246	-	1941	WP_286249964.1	MacB family efflux pump subunit	-
QUE75_RS10700 (MAALD49_21260)	2330243..2331388	-	1146	WP_286249966.1	efflux RND transporter periplasmic adaptor subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (56-219)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (71-119)

Sequences

Toxin

Protein

• Length: 265 a.a.
• Molecular weight: 29925.07 Da
• Isoelectric Point: 9.6555

>T44461 WP_286249961.1 NZ_AP028062:2326117-2326911 [Marinobacter shengliensis]
MNYKERIKNTLTNLQGQVFRVVESQEDIATTRIVDNMQEQARLEQLLDTSKPTIPERASKLHYLLATPFRYPPLKYGSRF
GRSFEPSLFYGAMSIPTALAETAFYRFVFTSHVSKPFKRPLTTLHTVFTARFRSSHGVRLQSPEWQDLQETLTDPVSYRE
SQALGSDLRQCGAEAFQFLSARALQAGLYQLPWQPEHGMDGLNVALFSPRALRDTAPKSYHKLIVATSDQQVSMSLTLAD
GRKQVHNFGREAFLVEGVIPQPAL

Nucleotide

• Length: 795 bp

>T44461 NZ_AP028062:2326117-2326911 [Marinobacter shengliensis]
TTGAACTACAAGGAGCGTATTAAAAACACCCTGACGAACCTACAGGGGCAGGTCTTTCGGGTGGTTGAGAGTCAGGAAGA
CATCGCCACCACCCGAATCGTTGACAACATGCAGGAACAGGCGCGCCTGGAGCAACTGCTGGATACCAGCAAACCGACGA
TCCCCGAGCGGGCCAGTAAACTGCACTACCTGCTTGCGACGCCCTTTCGATACCCGCCACTCAAATACGGCTCTCGGTTC
GGCCGTAGCTTCGAACCCAGCCTTTTCTACGGCGCCATGAGCATTCCGACAGCCCTGGCAGAGACCGCATTCTATCGGTT
TGTGTTCACCAGCCACGTGTCAAAACCCTTCAAACGGCCGCTGACCACGCTGCACACGGTTTTCACCGCCCGTTTTCGTT
CAAGCCACGGAGTGCGGCTTCAGTCCCCTGAGTGGCAGGACCTTCAAGAAACCCTGACCGACCCGGTCAGCTACCGGGAA
TCCCAGGCGCTGGGTAGCGACCTGCGCCAATGCGGCGCGGAAGCGTTTCAGTTTCTCTCTGCCCGGGCTCTTCAGGCCGG
CTTGTACCAGCTACCCTGGCAACCTGAGCACGGAATGGACGGACTCAACGTGGCGCTGTTCAGCCCCCGGGCACTCCGGG
ACACGGCGCCGAAGTCGTACCACAAACTCATCGTCGCCACCTCAGACCAGCAAGTATCCATGAGTCTGACGCTGGCTGAT
GGCCGTAAGCAGGTTCACAACTTTGGCCGGGAAGCCTTTCTGGTAGAGGGTGTTATTCCTCAACCGGCCCTGTAG

Antitoxin

Protein

• Length: 122 a.a.
• Molecular weight: 13175.97 Da
• Isoelectric Point: 8.4845

>AT44461 WP_061333408.1 NZ_AP028062:2325755-2326120 [Marinobacter shengliensis]
MNEPATLAPQTSDKALLAKALLNSAKAFGISQAEAAAIVGRNRSGLTRDGIDPDSKAGELALLFVRLYRSVYALTGGDNQ
AMAHWLNTPNNYFQDTPRDMIQSTEGLVRVIHYLDAMRGRI

Nucleotide

• Length: 366 bp

>AT44461 NZ_AP028062:2325755-2326120 [Marinobacter shengliensis]
ATGAACGAGCCGGCTACCCTGGCCCCCCAAACCAGCGACAAAGCCCTGCTGGCCAAGGCCTTGCTGAACTCCGCCAAGGC
GTTTGGTATTTCCCAGGCCGAAGCCGCCGCCATTGTTGGCCGCAATCGCAGCGGTTTGACCCGCGATGGCATCGATCCAG
ACAGCAAGGCGGGAGAACTGGCGCTGCTGTTCGTTCGCCTGTATCGGAGCGTTTACGCCCTGACCGGTGGCGACAACCAG
GCCATGGCCCACTGGCTCAATACGCCAAATAATTACTTTCAGGACACCCCCAGGGATATGATTCAGTCAACGGAAGGGCT
GGTCCGGGTGATTCATTATCTGGATGCCATGCGGGGAAGGATTTGA

Structures

Antitoxin

• AlphaFold DB: A0A137S3F5