Detailed information of TA system TA044459

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 1320888..1321423
• Replicon: chromosome
• Accession: NZ_AP028062
• Organism: Marinobacter shengliensis strain D49

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: QUE75_RS06120
• Protein ID: WP_286254382.1
• Coordinates: 1320888..1321184 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A137S2R8
• Locus tag: QUE75_RS06125
• Protein ID: WP_058091653.1
• Coordinates: 1321184..1321423 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QUE75_RS06100 (MAALD49_12060)	1316658..1317545	+	888	WP_286254374.1	3-hydroxyisobutyrate dehydrogenase	-
QUE75_RS06105 (MAALD49_12070)	1317584..1318915	-	1332	WP_286254377.1	acyltransferase	-
QUE75_RS06110 (MAALD49_12080)	1318923..1319627	-	705	WP_286254379.1	SGNH/GDSL hydrolase family protein	-
QUE75_RS06115 (MAALD49_12090)	1319707..1320732	-	1026	WP_072677782.1	DUF2235 domain-containing protein	-
QUE75_RS06120 (MAALD49_12100)	1320888..1321184	-	297	WP_286254382.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
QUE75_RS06125 (MAALD49_12110)	1321184..1321423	-	240	WP_058091653.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
QUE75_RS06130 (MAALD49_12120)	1321537..1322211	+	675	WP_286254385.1	hypothetical protein	-
QUE75_RS06135 (MAALD49_12130)	1322267..1322851	+	585	WP_286254388.1	DJ-1/PfpI family protein	-
QUE75_RS06140 (MAALD49_12140)	1323102..1324751	+	1650	WP_286254390.1	AMP-binding protein	-
QUE75_RS06145 (MAALD49_12150)	1324748..1325164	+	417	WP_061333513.1	PaaI family thioesterase	-
QUE75_RS06150 (MAALD49_12160)	1325253..1326056	+	804	WP_138437652.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-92)

Antitoxin

• Antitoxin ParD (4-71)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11557.35 Da
• Isoelectric Point: 9.7667

>T44459 WP_286254382.1 NZ_AP028062:c1321184-1320888 [Marinobacter shengliensis]
MLNFKLSRKAKADLKSIALYTERKWGRDQRNHYILQFDQCFHLLGENPNLGQTCDGIRADYRQYPQGSHIIFYRVATDSV
VEIIRILHKRMLPDGHLL

Nucleotide

• Length: 297 bp

>T44459 NZ_AP028062:c1321184-1320888 [Marinobacter shengliensis]
ATGCTGAATTTCAAGCTTTCCAGGAAGGCCAAAGCTGATCTCAAATCTATTGCACTGTACACGGAGCGTAAATGGGGCCG
AGATCAACGAAACCACTACATTCTCCAGTTTGACCAGTGCTTCCACCTACTGGGCGAAAACCCGAATCTGGGGCAAACCT
GCGATGGGATCCGCGCGGACTACCGACAGTATCCCCAAGGAAGTCACATCATATTCTATCGGGTAGCGACCGACAGTGTC
GTTGAGATTATCCGTATTCTACACAAACGCATGTTACCAGATGGGCATCTCCTTTAG

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 9151.10 Da
• Isoelectric Point: 4.5332

>AT44459 WP_058091653.1 NZ_AP028062:c1321423-1321184 [Marinobacter shengliensis]
MQKNTSITLGQHFDAFIAEQLKTGRYSSTSEVVRAGLRLLEESETRLTTLRKLLKEGEDSGFEDYSYDSFIRELDNEER

Nucleotide

• Length: 240 bp

>AT44459 NZ_AP028062:c1321423-1321184 [Marinobacter shengliensis]
ATGCAAAAGAACACCAGCATCACTCTAGGCCAACATTTTGATGCGTTCATTGCGGAACAACTCAAAACTGGCCGATACAG
CTCAACCAGCGAAGTTGTTCGTGCAGGATTGCGCCTGCTTGAAGAGTCCGAAACCCGCCTGACTACGCTCCGCAAACTTC
TTAAGGAAGGCGAAGATAGTGGCTTTGAAGACTACTCTTATGACTCTTTCATTCGCGAACTGGACAACGAAGAGCGCTAA

Structures

Antitoxin

• AlphaFold DB: A0A137S2R8