Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 722078..722667 Replicon chromosome
Accession NZ_AP028061
Organism Geobacter sulfurreducens subsp. ethanolicus strain OSK2A

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag QUE50_RS03655 Protein ID WP_286351574.1
Coordinates 722413..722667 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag QUE50_RS03650 Protein ID WP_286351573.1
Coordinates 722078..722416 (-) Length 113 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QUE50_RS03615 (GSUET_06960) 717632..717931 + 300 WP_286351567.1 hypothetical protein -
QUE50_RS03620 717909..718124 - 216 WP_286351568.1 hypothetical protein -
QUE50_RS03625 (GSUET_06970) 718293..719705 + 1413 WP_286351569.1 FAD-binding oxidoreductase -
QUE50_RS03630 719846..720190 + 345 WP_286351570.1 cupin domain-containing protein -
QUE50_RS03635 (GSUET_06990) 720422..721018 + 597 WP_286351571.1 dihydrofolate reductase family protein -
QUE50_RS03640 (GSUET_07000) 721282..721602 + 321 WP_286352495.1 DUF6516 family protein -
QUE50_RS03645 (GSUET_07010) 721604..721945 + 342 WP_286351572.1 transcriptional regulator -
QUE50_RS03650 (GSUET_07020) 722078..722416 - 339 WP_286351573.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
QUE50_RS03655 722413..722667 - 255 WP_286351574.1 type II toxin-antitoxin system HicA family toxin Toxin
QUE50_RS03660 (GSUET_07030) 722798..723325 + 528 WP_286351575.1 hypothetical protein -
QUE50_RS03665 (GSUET_07040) 723415..723909 + 495 WP_286351576.1 glutaredoxin domain-containing protein -
QUE50_RS03670 (GSUET_07050) 723952..724527 + 576 WP_214302913.1 DNA-3-methyladenine glycosylase I -
QUE50_RS03675 (GSUET_07060) 724524..724925 + 402 WP_014551351.1 hypothetical protein -
QUE50_RS03680 (GSUET_07070) 724965..725513 + 549 WP_014551352.1 cysteine hydrolase family protein -
QUE50_RS03685 (GSUET_07080) 725554..726159 + 606 WP_010941233.1 class I SAM-dependent methyltransferase -
QUE50_RS03690 (GSUET_07090) 726174..726656 + 483 WP_286351577.1 dihydrofolate reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-75)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9582.99 Da        Isoelectric Point: 10.8729

>T44455 WP_286351574.1 NZ_AP028061:c722667-722413 [Geobacter sulfurreducens subsp. ethanolicus]
VKRKNKKTLESIFAHPVPGNIQWPDILSLFRELGAEITEREGSRVGIRLFGDRRVFHRPHPSPDTDKGAVASIRKWLEEN
GVKP

Download         Length: 255 bp

>T44455 NZ_AP028061:c722667-722413 [Geobacter sulfurreducens subsp. ethanolicus]
GTGAAACGAAAAAATAAAAAAACTCTGGAATCTATCTTCGCACATCCCGTCCCCGGGAACATTCAGTGGCCGGATATTCT
TTCTCTTTTCAGAGAGCTGGGAGCTGAGATCACCGAGCGCGAAGGTTCCCGAGTGGGGATACGTCTTTTCGGCGATCGGC
GGGTATTTCATCGCCCGCATCCTTCGCCAGACACCGACAAAGGAGCTGTTGCTTCCATTCGGAAGTGGCTTGAAGAAAAC
GGAGTCAAACCATGA

Antitoxin


Download         Length: 113 a.a.        Molecular weight: 12366.90 Da        Isoelectric Point: 5.1029

>AT44455 WP_286351573.1 NZ_AP028061:c722416-722078 [Geobacter sulfurreducens subsp. ethanolicus]
MNNMNINGYDAVISYDPEINMFRGEFVGINGGADFYASTVDDLRKEGEISLNAFLEMCAEDGVEPRKHFSGKFNLRVPPA
LHQRLATQAAAHGKSINAWIIELLSECAAHSH

Download         Length: 339 bp

>AT44455 NZ_AP028061:c722416-722078 [Geobacter sulfurreducens subsp. ethanolicus]
ATGAACAACATGAACATTAATGGCTATGATGCTGTCATCTCATACGATCCCGAAATCAACATGTTCCGGGGAGAGTTTGT
CGGGATCAATGGCGGTGCTGATTTTTACGCCAGCACGGTGGATGATCTCCGGAAAGAGGGTGAAATTTCTCTCAACGCCT
TTCTCGAAATGTGTGCCGAAGATGGGGTTGAGCCGCGCAAGCATTTCTCCGGAAAATTCAATTTGAGAGTTCCCCCTGCG
CTACACCAGCGTCTTGCTACACAAGCCGCCGCGCACGGGAAAAGTATCAATGCCTGGATAATTGAGCTGCTTTCAGAGTG
TGCAGCGCACAGCCACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References