Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vagCD/VapC-VagC |
Location | 32165..32808 | Replicon | plasmid pTMTA98321 |
Accession | NZ_AP028051 | ||
Organism | Phytobacter diazotrophicus strain TA9832 |
Toxin (Protein)
Gene name | vagD | Uniprot ID | A0A348DMH6 |
Locus tag | QUE83_RS27425 | Protein ID | WP_047368852.1 |
Coordinates | 32165..32581 (-) | Length | 139 a.a. |
Antitoxin (Protein)
Gene name | vagC | Uniprot ID | A0A348DMH7 |
Locus tag | QUE83_RS27430 | Protein ID | WP_047368851.1 |
Coordinates | 32578..32808 (-) | Length | 77 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
QUE83_RS27415 (PDTA9832_54070) | 28940..29182 | + | 243 | WP_047368854.1 | hypothetical protein | - |
QUE83_RS27420 (PDTA9832_54080) | 30749..31978 | + | 1230 | WP_047368853.1 | HDOD domain-containing protein | - |
QUE83_RS27425 (PDTA9832_54090) | 32165..32581 | - | 417 | WP_047368852.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
QUE83_RS27430 (PDTA9832_54100) | 32578..32808 | - | 231 | WP_047368851.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
QUE83_RS27435 (PDTA9832_54110) | 33153..33413 | + | 261 | WP_007374405.1 | type II toxin-antitoxin system ParD family antitoxin | - |
QUE83_RS27440 (PDTA9832_54120) | 33400..33696 | + | 297 | WP_047368850.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
QUE83_RS27445 (PDTA9832_54130) | 33926..34360 | - | 435 | WP_007374421.1 | hypothetical protein | - |
QUE83_RS27450 (PDTA9832_54140) | 34578..35978 | - | 1401 | WP_007374420.1 | copper resistance membrane spanning protein PcoS | - |
QUE83_RS27455 (PDTA9832_54150) | 35975..36655 | - | 681 | WP_001188930.1 | copper response regulator transcription factor PcoR | - |
QUE83_RS27460 (PDTA9832_54160) | 36710..37639 | - | 930 | WP_000998778.1 | copper resistance inner membrane protein PcoD | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | - | - | 1..174856 | 174856 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 139 a.a. Molecular weight: 15042.32 Da Isoelectric Point: 7.2449
>T44449 WP_047368852.1 NZ_AP028051:c32581-32165 [Phytobacter diazotrophicus]
VNKTYMLDTNICSLIMREQPEAVLKRLEQAVLRNHRTVISAITYQEMRSGATGPKASPRHIALVDAFCARLDAILPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAVAAGAILVTNNTREFERVPGLVLEDWVN
VNKTYMLDTNICSLIMREQPEAVLKRLEQAVLRNHRTVISAITYQEMRSGATGPKASPRHIALVDAFCARLDAILPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAVAAGAILVTNNTREFERVPGLVLEDWVN
Download Length: 417 bp
>T44449 NZ_AP028051:c32581-32165 [Phytobacter diazotrophicus]
GTGAACAAAACGTATATGCTGGACACTAACATCTGCTCATTAATCATGCGCGAGCAACCGGAAGCGGTCCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCAACCACCGCACTGTGATCTCGGCCATCACCTACCAGGAGATGCGCTCCGGCGCCACGGGCC
CGAAGGCTTCGCCGCGCCATATTGCGCTGGTTGATGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCG
GCGGTCGACGCTACCACGGACATCCGGGTGGCGCTGCGCCTCGCAGGCACGCCGATCGGCCCGAATGACACGGCCATTGC
CGGGCATGCGGTTGCCGCCGGCGCCATCCTGGTGACCAACAATACAAGAGAGTTTGAACGGGTTCCGGGTCTGGTGCTGG
AAGACTGGGTAAATTAA
GTGAACAAAACGTATATGCTGGACACTAACATCTGCTCATTAATCATGCGCGAGCAACCGGAAGCGGTCCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCAACCACCGCACTGTGATCTCGGCCATCACCTACCAGGAGATGCGCTCCGGCGCCACGGGCC
CGAAGGCTTCGCCGCGCCATATTGCGCTGGTTGATGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCG
GCGGTCGACGCTACCACGGACATCCGGGTGGCGCTGCGCCTCGCAGGCACGCCGATCGGCCCGAATGACACGGCCATTGC
CGGGCATGCGGTTGCCGCCGGCGCCATCCTGGTGACCAACAATACAAGAGAGTTTGAACGGGTTCCGGGTCTGGTGCTGG
AAGACTGGGTAAATTAA
Antitoxin
Download Length: 77 a.a. Molecular weight: 8780.97 Da Isoelectric Point: 4.6583
>AT44449 WP_047368851.1 NZ_AP028051:c32808-32578 [Phytobacter diazotrophicus]
MRTVSIFKNGNNRAIRLPRDMDFEGVSELEIVREGDRIILRPVRPTWGSFAKMEKADPDFMAEREDVVSDEGRVDL
MRTVSIFKNGNNRAIRLPRDMDFEGVSELEIVREGDRIILRPVRPTWGSFAKMEKADPDFMAEREDVVSDEGRVDL
Download Length: 231 bp
>AT44449 NZ_AP028051:c32808-32578 [Phytobacter diazotrophicus]
ATGAGAACCGTATCTATTTTCAAAAACGGCAACAACCGCGCCATCCGTCTGCCCCGTGACATGGATTTTGAGGGGGTGAG
CGAGCTGGAGATCGTCCGGGAAGGAGACCGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGAAGATGG
AAAAAGCAGACCCGGACTTTATGGCGGAGCGTGAGGACGTTGTCAGTGACGAAGGACGGGTTGACCTGTGA
ATGAGAACCGTATCTATTTTCAAAAACGGCAACAACCGCGCCATCCGTCTGCCCCGTGACATGGATTTTGAGGGGGTGAG
CGAGCTGGAGATCGTCCGGGAAGGAGACCGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGAAGATGG
AAAAAGCAGACCCGGACTTTATGGCGGAGCGTGAGGACGTTGTCAGTGACGAAGGACGGGTTGACCTGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A348DMH6 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A348DMH7 |