Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4330278..4330897 Replicon chromosome
Accession NZ_AP028050
Organism Phytobacter diazotrophicus strain TA9832

Toxin (Protein)


Gene name Hha Uniprot ID A0A348DII6
Locus tag QUE83_RS20925 Protein ID WP_041852465.1
Coordinates 4330679..4330897 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A348DII5
Locus tag QUE83_RS20920 Protein ID WP_041852464.1
Coordinates 4330278..4330652 (+) Length 125 a.a.

Genomic Context

QUE83_RS20910QUE83_RS20915QUE83_RS20920QUE83_RS20925QUE83_RS20930QUE83_RS20935QUE83_RS20945QUE83_RS20940QUE83_RS20950QUE83_RS20955
Location: 4325389..4326585 (1197 bp)
Type: Others
Protein ID: WP_041852462.1
Location: 4326608..4329757 (3150 bp)
Type: Others
Protein ID: WP_125125202.1
Location: 4330278..4330652 (375 bp)
Type: Antitoxin
Protein ID: WP_041852464.1
Location: 4330679..4330897 (219 bp)
Type: Toxin
Protein ID: WP_041852465.1
Location: 4330966..4331532 (567 bp)
Type: Others
Protein ID: WP_125125203.1
Location: 4331632..4332099 (468 bp)
Type: Others
Protein ID: WP_041852467.1
Location: 4333622..4334323 (702 bp)
Type: Others
Protein ID: WP_041852469.1
Location: 4332077..4333522 (1446 bp)
Type: Others
Protein ID: WP_125125204.1
Location: 4334320..4334460 (141 bp)
Type: Others
Protein ID: WP_006818844.1
Location: 4334464..4334724 (261 bp)
Type: Others
Protein ID: WP_041852470.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
QUE83_RS20910 (4325389)4325389..4326585+1197WP_041852462.1multidrug efflux RND transporter periplasmic adaptor subunit AcrA-
QUE83_RS20915 (4326608)4326608..4329757+3150WP_125125202.1multidrug efflux RND transporter permease subunit AcrB-
QUE83_RS20920 (4330278)4330278..4330652+375WP_041852464.1Hha toxicity modulator TomBAntitoxin
QUE83_RS20925 (4330679)4330679..4330897+219WP_041852465.1HHA domain-containing proteinToxin
QUE83_RS20930 (4330966)4330966..4331532+567WP_125125203.1maltose O-acetyltransferase-
QUE83_RS20935 (4331632)4331632..4332099+468WP_041852467.1YlaC family protein-
QUE83_RS20940 (4332077)4332077..4333522-1446WP_125125204.1PLP-dependent aminotransferase family protein-
QUE83_RS20945 (4333622)4333622..4334323+702WP_041852469.1GNAT family protein-
QUE83_RS20950 (4334320)4334320..4334460-141WP_006818844.1type B 50S ribosomal protein L36-
QUE83_RS20955 (4334464)4334464..4334724-261WP_041852470.1type B 50S ribosomal protein L31-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8685.14 Da        Isoelectric Point: 8.9039

>T44447 WP_041852465.1 NZ_AP028050:4330679-4330897 [Phytobacter diazotrophicus]
MSDKPLTKIDYLMRLRRCQTIDTLERVIEKNKYELPDHELTVFYSAADHRLAELTMNKLYDKIPPSVWKFVR

Download         Length: 219 bp

>T44447 NZ_AP028050:4330679-4330897 [Phytobacter diazotrophicus]
ATGTCTGATAAGCCATTAACCAAAATTGATTATTTGATGCGATTACGACGTTGTCAGACAATTGACACGCTCGAACGCGT
TATTGAAAAAAATAAATACGAACTGCCTGACCATGAACTGACGGTGTTTTATTCAGCAGCCGATCATCGTCTGGCTGAGC
TAACCATGAATAAACTGTATGACAAAATCCCTCCTTCTGTGTGGAAATTCGTACGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14600.44 Da        Isoelectric Point: 5.5072

>AT44447 WP_041852464.1 NZ_AP028050:4330278-4330652 [Phytobacter diazotrophicus]
MDEYSPKRHDIAQLKFLCETLYHDCLLNLEESHHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNVSKANPVSHSC

Download         Length: 375 bp

>AT44447 NZ_AP028050:4330278-4330652 [Phytobacter diazotrophicus]
ATGGACGAATACTCGCCAAAAAGGCATGATATCGCGCAGCTTAAATTTCTCTGCGAAACGTTGTACCATGATTGTCTCCT
GAATCTTGAAGAAAGCCATCATGGATGGGTTAACGATCCTACTTCGGCAATCAATTTGCAGTTAAATGAGTTGATTGAAC
ATATAGCAACCTTCGCACTTAATTATAAAATTAAGTATAATGAAGATAATAAACTGATTGAGCAGATAGACGAATACCTT
GATGATACGTTTATGCTGTTCAGTAGCTACGGTATCAACACACAAGACTTGCAGAAATGGCGTAAATCGGGAAACCGATT
GTTCCGCTGTTTCGTCAATGTGAGCAAGGCTAACCCTGTTAGTCACTCCTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A348DII6

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A348DII5

References