Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4330278..4330897 Replicon chromosome
Accession NZ_AP028050
Organism Phytobacter diazotrophicus strain TA9832

Toxin (Protein)


Gene name Hha Uniprot ID A0A348DII6
Locus tag QUE83_RS20925 Protein ID WP_041852465.1
Coordinates 4330679..4330897 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A348DII5
Locus tag QUE83_RS20920 Protein ID WP_041852464.1
Coordinates 4330278..4330652 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QUE83_RS20910 (4325389) 4325389..4326585 + 1197 WP_041852462.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QUE83_RS20915 (4326608) 4326608..4329757 + 3150 WP_125125202.1 multidrug efflux RND transporter permease subunit AcrB -
QUE83_RS20920 (4330278) 4330278..4330652 + 375 WP_041852464.1 Hha toxicity modulator TomB Antitoxin
QUE83_RS20925 (4330679) 4330679..4330897 + 219 WP_041852465.1 HHA domain-containing protein Toxin
QUE83_RS20930 (4330966) 4330966..4331532 + 567 WP_125125203.1 maltose O-acetyltransferase -
QUE83_RS20935 (4331632) 4331632..4332099 + 468 WP_041852467.1 YlaC family protein -
QUE83_RS20940 (4332077) 4332077..4333522 - 1446 WP_125125204.1 PLP-dependent aminotransferase family protein -
QUE83_RS20945 (4333622) 4333622..4334323 + 702 WP_041852469.1 GNAT family protein -
QUE83_RS20950 (4334320) 4334320..4334460 - 141 WP_006818844.1 type B 50S ribosomal protein L36 -
QUE83_RS20955 (4334464) 4334464..4334724 - 261 WP_041852470.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8685.14 Da        Isoelectric Point: 8.9039

>T44447 WP_041852465.1 NZ_AP028050:4330679-4330897 [Phytobacter diazotrophicus]
MSDKPLTKIDYLMRLRRCQTIDTLERVIEKNKYELPDHELTVFYSAADHRLAELTMNKLYDKIPPSVWKFVR

Download         Length: 219 bp

>T44447 NZ_AP028050:4330679-4330897 [Phytobacter diazotrophicus]
ATGTCTGATAAGCCATTAACCAAAATTGATTATTTGATGCGATTACGACGTTGTCAGACAATTGACACGCTCGAACGCGT
TATTGAAAAAAATAAATACGAACTGCCTGACCATGAACTGACGGTGTTTTATTCAGCAGCCGATCATCGTCTGGCTGAGC
TAACCATGAATAAACTGTATGACAAAATCCCTCCTTCTGTGTGGAAATTCGTACGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14600.44 Da        Isoelectric Point: 5.5072

>AT44447 WP_041852464.1 NZ_AP028050:4330278-4330652 [Phytobacter diazotrophicus]
MDEYSPKRHDIAQLKFLCETLYHDCLLNLEESHHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNVSKANPVSHSC

Download         Length: 375 bp

>AT44447 NZ_AP028050:4330278-4330652 [Phytobacter diazotrophicus]
ATGGACGAATACTCGCCAAAAAGGCATGATATCGCGCAGCTTAAATTTCTCTGCGAAACGTTGTACCATGATTGTCTCCT
GAATCTTGAAGAAAGCCATCATGGATGGGTTAACGATCCTACTTCGGCAATCAATTTGCAGTTAAATGAGTTGATTGAAC
ATATAGCAACCTTCGCACTTAATTATAAAATTAAGTATAATGAAGATAATAAACTGATTGAGCAGATAGACGAATACCTT
GATGATACGTTTATGCTGTTCAGTAGCTACGGTATCAACACACAAGACTTGCAGAAATGGCGTAAATCGGGAAACCGATT
GTTCCGCTGTTTCGTCAATGTGAGCAAGGCTAACCCTGTTAGTCACTCCTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A348DII6

Antitoxin

Source ID Structure
AlphaFold DB A0A348DII5

References