Detailed information of TA system TA044438

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 2833538..2834460
• Replicon: chromosome
• Accession: NZ_AP028050
• Organism: Phytobacter diazotrophicus strain TA9832

Toxin (Protein)

• Gene name: -
• Uniprot ID: A0A348DED3
• Locus tag: QUE83_RS13660
• Protein ID: WP_039079059.1
• Coordinates: 2833984..2834460 (+)
• Length: 159 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A348DED2
• Locus tag: QUE83_RS13655
• Protein ID: WP_071194172.1
• Coordinates: 2833538..2833984 (+)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QUE83_RS13645 (2829211)	2829211..2832258	-	3048	WP_125124690.1	formate dehydrogenase-N subunit alpha	-
QUE83_RS13650 (2832591)	2832591..2833472	+	882	WP_125124691.1	aromatic amino acid DMT transporter YddG	-
QUE83_RS13655 (2833538)	2833538..2833984	+	447	WP_071194172.1	DUF2384 domain-containing protein	Antitoxin
QUE83_RS13660 (2833984)	2833984..2834460	+	477	WP_039079059.1	RES family NAD+ phosphorylase	Toxin
QUE83_RS13665 (2834444)	2834444..2835946	-	1503	WP_125124692.1	MFS transporter	-
QUE83_RS13670 (2836059)	2836059..2836649	+	591	WP_125124693.1	TetR family transcriptional regulator	-
QUE83_RS13675 (2836631)	2836631..2837473	-	843	WP_125124694.1	N-hydroxyarylamine O-acetyltransferase	-
QUE83_RS13680 (2837549)	2837549..2839204	-	1656	WP_125124695.1	iron ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (5-150)

Antitoxin

• Antitoxin Xre-like, helix-turn-helix domain (28-90)

Sequences

Toxin

Protein

• Length: 159 a.a.
• Molecular weight: 17725.30 Da
• Isoelectric Point: 5.2290

>T44438 WP_039079059.1 NZ_AP028050:2833984-2834460 [Phytobacter diazotrophicus]
METVTFWRLVKERYALTAFDGYGARTFGGRWNSPGHECVYLGESKALCVLETLVHLEIEDIAQGYCFLTLDVPRNLIATL
DLTALPEDWKADPPPVSTQHIGDEWLASKQNGLVLRVPSTITGEWNALFNPEHPQAAKVLKSVKSEPFMLDPRLSRPC

Nucleotide

• Length: 477 bp

>T44438 NZ_AP028050:2833984-2834460 [Phytobacter diazotrophicus]
ATGGAAACTGTCACCTTCTGGCGTCTGGTCAAAGAACGCTATGCGCTGACCGCCTTCGACGGTTACGGCGCGCGAACCTT
TGGCGGACGCTGGAATTCACCGGGGCATGAATGCGTCTACCTGGGTGAATCAAAAGCTCTCTGCGTGCTGGAAACACTGG
TACATCTTGAGATTGAAGATATCGCCCAGGGCTACTGTTTCTTAACCCTCGATGTACCACGTAATCTTATCGCGACGCTG
GATTTGACCGCCCTGCCCGAAGACTGGAAAGCTGACCCGCCGCCTGTTTCCACGCAACACATCGGCGATGAGTGGCTGGC
ATCAAAGCAAAACGGGCTGGTACTGCGCGTCCCCAGTACCATCACCGGCGAATGGAACGCGCTGTTTAACCCCGAACACC
CACAGGCGGCGAAAGTCCTCAAAAGCGTAAAGTCCGAACCCTTTATGCTGGATCCCCGTCTTAGCCGTCCTTGCTAG

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 15690.07 Da
• Isoelectric Point: 8.9810

>AT44438 WP_071194172.1 NZ_AP028050:2833538-2833984 [Phytobacter diazotrophicus]
MQLYTPGVRAIPHDLLSILGLPATAIAAHDSINAGLSAGVLRDIAGAVSLDEITLCRMAGIDRNTYSRRLNSAEKRFSPE
QSARVYTLARVISAARELFEGDSERMATWLNKPAKGLGGKKPAELLSTPAGAEAVLTLIGRLEHGVIG

Nucleotide

• Length: 447 bp

>AT44438 NZ_AP028050:2833538-2833984 [Phytobacter diazotrophicus]
ATGCAACTCTATACACCGGGCGTACGCGCGATCCCGCACGACCTGCTCAGCATCCTGGGGCTGCCCGCCACGGCGATTGC
CGCTCATGACAGCATTAATGCCGGTCTGAGTGCAGGTGTGTTGCGTGATATCGCTGGCGCCGTCTCTCTTGATGAAATCA
CGCTGTGCCGAATGGCTGGCATTGATCGTAATACCTATAGCCGCAGGCTTAACAGCGCGGAAAAACGCTTTTCACCAGAA
CAGAGTGCGCGCGTCTACACGCTGGCACGAGTGATCAGCGCCGCTCGTGAGTTATTTGAAGGTGACAGCGAGCGTATGGC
CACCTGGCTCAATAAACCCGCGAAAGGCCTTGGCGGTAAAAAACCCGCAGAGCTTCTCTCGACACCCGCCGGTGCGGAAG
CGGTACTGACATTGATTGGTCGCCTTGAGCATGGTGTGATCGGCTAA

Structures

Toxin

• AlphaFold DB: A0A348DED3

Antitoxin

• AlphaFold DB: A0A348DED2