Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4363247..4363866 Replicon chromosome
Accession NZ_AP028047
Organism Phytobacter diazotrophicus strain TA9759

Toxin (Protein)


Gene name Hha Uniprot ID A0A348DII6
Locus tag QUE80_RS21090 Protein ID WP_041852465.1
Coordinates 4363648..4363866 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A348DII5
Locus tag QUE80_RS21085 Protein ID WP_041852464.1
Coordinates 4363247..4363621 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QUE80_RS21075 (4358358) 4358358..4359554 + 1197 WP_041852462.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QUE80_RS21080 (4359577) 4359577..4362726 + 3150 WP_125125202.1 multidrug efflux RND transporter permease subunit AcrB -
QUE80_RS21085 (4363247) 4363247..4363621 + 375 WP_041852464.1 Hha toxicity modulator TomB Antitoxin
QUE80_RS21090 (4363648) 4363648..4363866 + 219 WP_041852465.1 HHA domain-containing protein Toxin
QUE80_RS21095 (4363935) 4363935..4364501 + 567 WP_125125203.1 maltose O-acetyltransferase -
QUE80_RS21100 (4364601) 4364601..4365068 + 468 WP_041852467.1 YlaC family protein -
QUE80_RS21105 (4365046) 4365046..4366491 - 1446 WP_125125204.1 PLP-dependent aminotransferase family protein -
QUE80_RS21110 (4366591) 4366591..4367292 + 702 WP_041852469.1 GNAT family protein -
QUE80_RS21115 (4367289) 4367289..4367429 - 141 WP_006818844.1 type B 50S ribosomal protein L36 -
QUE80_RS21120 (4367433) 4367433..4367693 - 261 WP_041852470.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8685.14 Da        Isoelectric Point: 8.9039

>T44427 WP_041852465.1 NZ_AP028047:4363648-4363866 [Phytobacter diazotrophicus]
MSDKPLTKIDYLMRLRRCQTIDTLERVIEKNKYELPDHELTVFYSAADHRLAELTMNKLYDKIPPSVWKFVR

Download         Length: 219 bp

>T44427 NZ_AP028047:4363648-4363866 [Phytobacter diazotrophicus]
ATGTCTGATAAGCCATTAACCAAAATTGATTATTTGATGCGATTACGACGTTGTCAGACAATTGACACGCTCGAACGCGT
TATTGAAAAAAATAAATACGAACTGCCTGACCATGAACTGACGGTGTTTTATTCAGCAGCCGATCATCGTCTGGCTGAGC
TAACCATGAATAAACTGTATGACAAAATCCCTCCTTCTGTGTGGAAATTCGTACGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14600.44 Da        Isoelectric Point: 5.5072

>AT44427 WP_041852464.1 NZ_AP028047:4363247-4363621 [Phytobacter diazotrophicus]
MDEYSPKRHDIAQLKFLCETLYHDCLLNLEESHHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNVSKANPVSHSC

Download         Length: 375 bp

>AT44427 NZ_AP028047:4363247-4363621 [Phytobacter diazotrophicus]
ATGGACGAATACTCGCCAAAAAGGCATGATATCGCGCAGCTTAAATTTCTCTGCGAAACGTTGTACCATGATTGTCTCCT
GAATCTTGAAGAAAGCCATCATGGATGGGTTAACGATCCTACTTCGGCAATCAATTTGCAGTTAAATGAGTTGATTGAAC
ATATAGCAACCTTCGCACTTAATTATAAAATTAAGTATAATGAAGATAATAAACTGATTGAGCAGATAGACGAATACCTT
GATGATACGTTTATGCTGTTCAGTAGCTACGGTATCAACACACAAGACTTGCAGAAATGGCGTAAATCGGGAAACCGATT
GTTCCGCTGTTTCGTCAATGTGAGCAAGGCTAACCCTGTTAGTCACTCCTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A348DII6

Antitoxin

Source ID Structure
AlphaFold DB A0A348DII5

References