Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 33225..33868 Replicon plasmid pTMTA97301
Accession NZ_AP028042
Organism Phytobacter diazotrophicus strain TA9730

Toxin (Protein)


Gene name vagD Uniprot ID A0A348DMH6
Locus tag QUE90_RS27115 Protein ID WP_047368852.1
Coordinates 33225..33641 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A348DMH7
Locus tag QUE90_RS27120 Protein ID WP_047368851.1
Coordinates 33638..33868 (-) Length 77 a.a.

Genomic Context

QUE90_RS27105QUE90_RS27110QUE90_RS27125QUE90_RS27130QUE90_RS27115QUE90_RS27120QUE90_RS27135QUE90_RS27140QUE90_RS27145QUE90_RS27150
Location: 30000..30242 (243 bp)
Type: Others
Protein ID: WP_047368854.1
Location: 31809..33038 (1230 bp)
Type: Others
Protein ID: WP_047368853.1
Location: 34213..34473 (261 bp)
Type: Others
Protein ID: WP_007374405.1
Location: 34460..34756 (297 bp)
Type: Others
Protein ID: WP_047368850.1
Location: 33225..33641 (417 bp)
Type: Toxin
Protein ID: WP_047368852.1
Location: 33638..33868 (231 bp)
Type: Antitoxin
Protein ID: WP_047368851.1
Location: 34986..35420 (435 bp)
Type: Others
Protein ID: WP_007374421.1
Location: 35638..37038 (1401 bp)
Type: Others
Protein ID: WP_007374420.1
Location: 37035..37715 (681 bp)
Type: Others
Protein ID: WP_001188930.1
Location: 37770..38699 (930 bp)
Type: Others
Protein ID: WP_000998778.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
QUE90_RS27105 (PDTA9730_53460)30000..30242+243WP_047368854.1hypothetical protein-
QUE90_RS27110 (PDTA9730_53470)31809..33038+1230WP_047368853.1HDOD domain-containing protein-
QUE90_RS27115 (PDTA9730_53480)33225..33641-417WP_047368852.1type II toxin-antitoxin system VapC family toxinToxin
QUE90_RS27120 (PDTA9730_53490)33638..33868-231WP_047368851.1type II toxin-antitoxin system VapB family antitoxinAntitoxin
QUE90_RS27125 (PDTA9730_53500)34213..34473+261WP_007374405.1type II toxin-antitoxin system ParD family antitoxin-
QUE90_RS27130 (PDTA9730_53510)34460..34756+297WP_047368850.1type II toxin-antitoxin system RelE/ParE family toxin-
QUE90_RS27135 (PDTA9730_53520)34986..35420-435WP_007374421.1hypothetical protein-
QUE90_RS27140 (PDTA9730_53530)35638..37038-1401WP_007374420.1copper resistance membrane spanning protein PcoS-
QUE90_RS27145 (PDTA9730_53540)37035..37715-681WP_001188930.1copper response regulator transcription factor PcoR-
QUE90_RS27150 (PDTA9730_53550)37770..38699-930WP_000998778.1copper resistance inner membrane protein PcoD-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmid--1..175916175916


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-49)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15042.32 Da        Isoelectric Point: 7.2449

>T44409 WP_047368852.1 NZ_AP028042:c33641-33225 [Phytobacter diazotrophicus]
VNKTYMLDTNICSLIMREQPEAVLKRLEQAVLRNHRTVISAITYQEMRSGATGPKASPRHIALVDAFCARLDAILPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAVAAGAILVTNNTREFERVPGLVLEDWVN

Download         Length: 417 bp

>T44409 NZ_AP028042:c33641-33225 [Phytobacter diazotrophicus]
GTGAACAAAACGTATATGCTGGACACTAACATCTGCTCATTAATCATGCGCGAGCAACCGGAAGCGGTCCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCAACCACCGCACTGTGATCTCGGCCATCACCTACCAGGAGATGCGCTCCGGCGCCACGGGCC
CGAAGGCTTCGCCGCGCCATATTGCGCTGGTTGATGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCG
GCGGTCGACGCTACCACGGACATCCGGGTGGCGCTGCGCCTCGCAGGCACGCCGATCGGCCCGAATGACACGGCCATTGC
CGGGCATGCGGTTGCCGCCGGCGCCATCCTGGTGACCAACAATACAAGAGAGTTTGAACGGGTTCCGGGTCTGGTGCTGG
AAGACTGGGTAAATTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8780.97 Da        Isoelectric Point: 4.6583

>AT44409 WP_047368851.1 NZ_AP028042:c33868-33638 [Phytobacter diazotrophicus]
MRTVSIFKNGNNRAIRLPRDMDFEGVSELEIVREGDRIILRPVRPTWGSFAKMEKADPDFMAEREDVVSDEGRVDL

Download         Length: 231 bp

>AT44409 NZ_AP028042:c33868-33638 [Phytobacter diazotrophicus]
ATGAGAACCGTATCTATTTTCAAAAACGGCAACAACCGCGCCATCCGTCTGCCCCGTGACATGGATTTTGAGGGGGTGAG
CGAGCTGGAGATCGTCCGGGAAGGAGACCGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGAAGATGG
AAAAAGCAGACCCGGACTTTATGGCGGAGCGTGAGGACGTTGTCAGTGACGAAGGACGGGTTGACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A348DMH6

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A348DMH7

References