Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 5212240..5212903 Replicon chromosome
Accession NZ_AP028041
Organism Phytobacter diazotrophicus strain TA9730

Toxin (Protein)


Gene name tad Uniprot ID A0A348DL83
Locus tag QUE90_RS25040 Protein ID WP_039077908.1
Coordinates 5212240..5212584 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID A0A348DL84
Locus tag QUE90_RS25045 Protein ID WP_071194355.1
Coordinates 5212586..5212903 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QUE90_RS25020 (5207917) 5207917..5209323 - 1407 WP_039077905.1 replicative DNA helicase -
QUE90_RS25025 (5209382) 5209382..5210365 + 984 WP_039077906.1 quinone oxidoreductase -
QUE90_RS25030 (5210654) 5210654..5210896 - 243 WP_039077907.1 envelope stress response protein PspG -
QUE90_RS25035 (5211049) 5211049..5212047 - 999 WP_039077935.1 tRNA dihydrouridine(20/20a) synthase DusA -
QUE90_RS25040 (5212240) 5212240..5212584 + 345 WP_039077908.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QUE90_RS25045 (5212586) 5212586..5212903 + 318 WP_071194355.1 helix-turn-helix transcriptional regulator Antitoxin
QUE90_RS25050 (5212945) 5212945..5214261 - 1317 WP_039077910.1 conjugal transfer protein TraF -
QUE90_RS25055 (5214534) 5214534..5215049 + 516 WP_039077912.1 zinc uptake transcriptional repressor Zur -
QUE90_RS25060 (5215157) 5215157..5215366 - 210 WP_039077936.1 CsbD family protein -
QUE90_RS25065 (5215464) 5215464..5215652 + 189 WP_071194358.1 hypothetical protein -
QUE90_RS25070 (5215627) 5215627..5216241 - 615 WP_039077914.1 transcriptional repressor LexA -
QUE90_RS25075 (5216350) 5216350..5216718 - 369 WP_079497650.1 diacylglycerol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(35-86)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12655.46 Da        Isoelectric Point: 9.5820

>T44408 WP_039077908.1 NZ_AP028041:5212240-5212584 [Phytobacter diazotrophicus]
MKPLYWVGSSKKDLQSLPEDVQDVFGYALHLAQDGGKHPQAKPLKGFGGAGVLEVVEDYCTDTYRAVYTLKFRQAVYVLH
AFQKKSSSGMQTPKSDIEKIRERLKAAEAHARGA

Download         Length: 345 bp

>T44408 NZ_AP028041:5212240-5212584 [Phytobacter diazotrophicus]
ATGAAGCCACTGTATTGGGTGGGGAGCAGCAAAAAAGATCTTCAGTCTCTGCCGGAGGATGTTCAGGATGTTTTTGGTTA
TGCGTTGCATCTCGCACAAGACGGAGGTAAGCATCCCCAGGCAAAACCGTTAAAAGGATTTGGGGGCGCAGGTGTGCTGG
AGGTGGTCGAAGACTATTGCACCGATACTTATCGCGCGGTTTATACCCTGAAATTCAGACAGGCGGTCTATGTGCTACAT
GCATTTCAGAAGAAGTCGTCATCCGGTATGCAAACCCCCAAATCTGATATAGAAAAAATTCGAGAACGTCTTAAGGCAGC
AGAAGCCCATGCCAGAGGAGCATAA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11644.64 Da        Isoelectric Point: 11.1929

>AT44408 WP_071194355.1 NZ_AP028041:5212586-5212903 [Phytobacter diazotrophicus]
MSQNIDISSGNVYADIGLDNADEMQVKAQLATTIGNIIKSRRLTQVEAAKLLGMTQPRLSNMLRGQFRGISEVKMLECLT
RLGRDVQIVVGRPRRTPGRMKVVFA

Download         Length: 318 bp

>AT44408 NZ_AP028041:5212586-5212903 [Phytobacter diazotrophicus]
ATGAGCCAGAATATCGATATCAGCAGCGGCAATGTTTATGCCGACATTGGACTGGACAATGCGGATGAAATGCAGGTTAA
AGCGCAGCTTGCTACCACCATTGGCAATATCATTAAAAGTCGTCGTCTTACTCAGGTGGAGGCGGCAAAGTTATTGGGGA
TGACACAGCCCAGGCTATCAAATATGCTGCGCGGCCAATTTCGCGGCATAAGTGAAGTAAAAATGCTTGAATGTCTGACA
CGCTTAGGGCGCGATGTTCAAATTGTGGTTGGGCGCCCGCGCCGTACCCCGGGACGTATGAAGGTGGTTTTTGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A348DL83

Antitoxin

Source ID Structure
AlphaFold DB A0A348DL84

References