Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 202050..202789 Replicon chromosome
Accession NZ_AP028041
Organism Phytobacter diazotrophicus strain TA9730

Toxin (Protein)


Gene name tacT Uniprot ID A0A348D6L8
Locus tag QUE90_RS00975 Protein ID WP_039080181.1
Coordinates 202304..202789 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A348D6L7
Locus tag QUE90_RS00970 Protein ID WP_039080180.1
Coordinates 202050..202316 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QUE90_RS00950 (198122) 198122..198427 + 306 WP_172600614.1 YsaB family lipoprotein -
QUE90_RS00955 (198533) 198533..199444 + 912 WP_004126458.1 glycine--tRNA ligase subunit alpha -
QUE90_RS00960 (199454) 199454..201523 + 2070 WP_039080179.1 glycine--tRNA ligase subunit beta -
QUE90_RS00965 (201644) 201644..201892 + 249 Protein_191 IS30 family transposase -
QUE90_RS00970 (202050) 202050..202316 + 267 WP_039080180.1 DUF1778 domain-containing protein Antitoxin
QUE90_RS00975 (202304) 202304..202789 + 486 WP_039080181.1 GNAT family N-acetyltransferase Toxin
QUE90_RS00980 (203375) 203375..204994 + 1620 WP_107222628.1 ABC-F family ATP-binding cassette domain-containing protein -
QUE90_RS00985 (205038) 205038..205331 - 294 WP_039080183.1 HTH-type transcriptional regulator -
QUE90_RS00990 (205709) 205709..206419 + 711 WP_039080184.1 DUF3053 domain-containing protein -
QUE90_RS00995 (206485) 206485..207459 - 975 WP_071195041.1 glyoxylate/hydroxypyruvate reductase GhrB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(30-152)

Antitoxin

Vibrio phage ICP1, Orf50

(2-87)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17775.56 Da        Isoelectric Point: 10.2934

>T44392 WP_039080181.1 NZ_AP028041:202304-202789 [Phytobacter diazotrophicus]
VGRVTAPEPLSNFHQVAAFVSGEAVLDDWLKQRGLKNQALGAARTFVVCKKDTKQIVGFYSLATGSVNHTETTGNLRRNM
PDPIPVIILARLAVDVSFRGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKPSQTQQRTLFLKLP
Q

Download         Length: 486 bp

>T44392 NZ_AP028041:202304-202789 [Phytobacter diazotrophicus]
GTGGGACGTGTAACAGCGCCAGAGCCTTTATCCAATTTCCATCAGGTGGCGGCGTTTGTTAGCGGTGAAGCTGTGCTCGA
TGATTGGCTAAAGCAGAGAGGCCTCAAAAATCAGGCTCTCGGAGCTGCCCGAACTTTTGTTGTATGTAAGAAAGACACGA
AACAAATAGTCGGTTTTTACTCTTTGGCCACCGGTAGCGTCAACCATACAGAAACTACAGGCAACCTTCGGCGTAACATG
CCAGACCCTATTCCTGTGATTATACTCGCCCGGCTTGCTGTCGACGTCTCCTTTCGTGGAAAAGGGCTTGGCGCTGATTT
ACTCCACGATGCGGTGCTTCGTTGTTATCGAGTTGCTGAAAATATTGGTGTGCGTGCAATCATGGTTCACGCGCTGACGG
AAGAAGCCAAAAATTTCTATATTCACCATGGTTTCAAGCCATCACAAACTCAGCAGCGGACGTTATTCCTTAAACTTCCT
CAATAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT44392 WP_039080180.1 NZ_AP028041:202050-202316 [Phytobacter diazotrophicus]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILERRAFNFNDEQYAEFIDMLDAPVADDPVIDKLL
ARKPQWDV

Download         Length: 267 bp

>AT44392 NZ_AP028041:202050-202316 [Phytobacter diazotrophicus]
ATGAAATCAGATGTTCAACTTAACCTTAGAGCCAAGGAATCACAGCGAGCACTCATTGATGCCGCCGCTGAGATCCTGCA
CAAATCACGTACAGATTTCATTCTGGAAATGGCCTGTCAGGCTGCTGAAAATGTGATTCTTGAGCGACGTGCCTTTAATT
TTAACGATGAGCAATATGCAGAGTTCATCGATATGCTCGATGCACCGGTTGCGGATGATCCCGTTATCGACAAACTGCTG
GCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A348D6L8

Antitoxin

Source ID Structure
AlphaFold DB A0A348D6L7

References