Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 4191537..4192372 | Replicon | chromosome |
| Accession | NZ_AP027971 | ||
| Organism | Escherichia coli strain VE-V10-F | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A0J2AEA6 |
| Locus tag | QQK73_RS20510 | Protein ID | WP_000854759.1 |
| Coordinates | 4191537..4191914 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | S1NM52 |
| Locus tag | QQK73_RS20515 | Protein ID | WP_001295723.1 |
| Coordinates | 4192004..4192372 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QQK73_RS20480 (4187165) | 4187165..4187911 | - | 747 | WP_001016257.1 | IS21-like element ISEc12 family helper ATPase IstB | - |
| QQK73_RS20485 (4187926) | 4187926..4189467 | - | 1542 | WP_001298859.1 | IS21-like element ISEc12 family transposase | - |
| QQK73_RS20490 (4190061) | 4190061..4190237 | - | 177 | Protein_4009 | helix-turn-helix domain-containing protein | - |
| QQK73_RS20495 (4190604) | 4190604..4190753 | - | 150 | Protein_4010 | hypothetical protein | - |
| QQK73_RS20500 (4190859) | 4190859..4191035 | - | 177 | WP_000839286.1 | DUF957 domain-containing protein | - |
| QQK73_RS20505 (4191052) | 4191052..4191540 | - | 489 | WP_000761690.1 | DUF5983 family protein | - |
| QQK73_RS20510 (4191537) | 4191537..4191914 | - | 378 | WP_000854759.1 | TA system toxin CbtA family protein | Toxin |
| QQK73_RS20515 (4192004) | 4192004..4192372 | - | 369 | WP_001295723.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| QQK73_RS20520 (4192535) | 4192535..4192756 | - | 222 | WP_000692345.1 | DUF987 domain-containing protein | - |
| QQK73_RS20525 (4192819) | 4192819..4193295 | - | 477 | WP_123004423.1 | RadC family protein | - |
| QQK73_RS20530 (4193311) | 4193311..4193460 | - | 150 | Protein_4017 | antirestriction protein | - |
| QQK73_RS20535 (4193736) | 4193736..4193852 | - | 117 | Protein_4018 | hypothetical protein | - |
| QQK73_RS20540 (4193971) | 4193971..4194120 | + | 150 | WP_071526287.1 | Hha/YmoA family nucleoid-associated regulatory protein | - |
| QQK73_RS20545 (4194453) | 4194453..4194650 | - | 198 | WP_001547002.1 | hypothetical protein | - |
| QQK73_RS20550 (4194850) | 4194850..4195419 | + | 570 | WP_000221530.1 | inovirus Gp2 family protein | - |
| QQK73_RS20555 (4195679) | 4195679..4196080 | + | 402 | WP_000270962.1 | putative zinc ribbon protein | - |
| QQK73_RS20560 (4196068) | 4196068..4196502 | + | 435 | WP_001221615.1 | zinc-ribbon domain-containing protein | - |
| QQK73_RS20565 (4196857) | 4196857..4197237 | + | 381 | WP_001171523.1 | transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 4178731..4222943 | 44212 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14144.26 Da Isoelectric Point: 7.3249
>T44350 WP_000854759.1 NZ_AP027971:c4191914-4191537 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDLPGF
SACTHSQLINSIDILRARRATGLMIRDNYRTVNNITLGKHPEAKR
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDLPGF
SACTHSQLINSIDILRARRATGLMIRDNYRTVNNITLGKHPEAKR
Download Length: 378 bp
>T44350 NZ_AP027971:c4191914-4191537 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCAGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGTACCGACCTGCCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGATCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCAGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGTACCGACCTGCCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGATCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13592.40 Da Isoelectric Point: 6.6255
>AT44350 WP_001295723.1 NZ_AP027971:c4192372-4192004 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK
Download Length: 369 bp
>AT44350 NZ_AP027971:c4192372-4192004 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0J2AEA6 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | S1NM52 |