Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1875334..1876165 Replicon chromosome
Accession NZ_AP027971
Organism Escherichia coli strain VE-V10-F

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag QQK73_RS09120 Protein ID WP_069024963.1
Coordinates 1875334..1875708 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B3Y195
Locus tag QQK73_RS09125 Protein ID WP_001285585.1
Coordinates 1875797..1876165 (-) Length 123 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQK73_RS09080 (1870730) 1870730..1871896 + 1167 WP_000830163.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
QQK73_RS09085 (1872015) 1872015..1872488 + 474 WP_001105393.1 DNA gyrase inhibitor SbmC -
QQK73_RS09090 (1872686) 1872686..1873744 + 1059 WP_001200905.1 FUSC family protein -
QQK73_RS09095 (1873916) 1873916..1874245 + 330 WP_000450409.1 DUF496 family protein -
QQK73_RS09100 (1874346) 1874346..1874480 - 135 WP_001297944.1 EutP/PduV family microcompartment system protein -
QQK73_RS09105 (1874600) 1874600..1874728 + 129 Protein_1781 transposase domain-containing protein -
QQK73_RS09110 (1875017) 1875017..1875097 - 81 Protein_1782 hypothetical protein -
QQK73_RS09115 (1875143) 1875143..1875337 - 195 WP_000988600.1 DUF5983 family protein -
QQK73_RS09120 (1875334) 1875334..1875708 - 375 WP_069024963.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
QQK73_RS09125 (1875797) 1875797..1876165 - 369 WP_001285585.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
QQK73_RS09130 (1876239) 1876239..1876460 - 222 WP_000692323.1 DUF987 domain-containing protein -
QQK73_RS09135 (1876523) 1876523..1876999 - 477 WP_001186726.1 RadC family protein -
QQK73_RS09140 (1877015) 1877015..1877494 - 480 WP_000860087.1 antirestriction protein -
QQK73_RS09145 (1877576) 1877576..1878394 - 819 WP_001234629.1 DUF932 domain-containing protein -
QQK73_RS09150 (1878494) 1878494..1878727 - 234 WP_001119729.1 DUF905 family protein -
QQK73_RS09155 (1878806) 1878806..1879261 - 456 WP_000581504.1 IrmA family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-112)

Antitoxin

(18-117)


Sequences


Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.90 Da        Isoelectric Point: 7.1328

>T44339 WP_069024963.1 NZ_AP027971:c1875708-1875334 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGQYPEAK

Download         Length: 375 bp

>T44339 NZ_AP027971:c1875708-1875334 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTCAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13593.48 Da        Isoelectric Point: 6.3139

>AT44339 WP_001285585.1 NZ_AP027971:c1876165-1875797 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT44339 NZ_AP027971:c1876165-1875797 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LW60

References