Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1362554..1363179 Replicon chromosome
Accession NZ_AP027971
Organism Escherichia coli strain VE-V10-F

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag QQK73_RS06700 Protein ID WP_000911330.1
Coordinates 1362781..1363179 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag QQK73_RS06695 Protein ID WP_284329794.1
Coordinates 1362554..1362781 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQK73_RS06670 (1358357) 1358357..1358827 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
QQK73_RS06675 (1358827) 1358827..1359399 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
QQK73_RS06680 (1359545) 1359545..1360423 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
QQK73_RS06685 (1360440) 1360440..1361474 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
QQK73_RS06690 (1361687) 1361687..1362400 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
QQK73_RS06695 (1362554) 1362554..1362781 + 228 WP_284329794.1 toxin-antitoxin system antitoxin VapB Antitoxin
QQK73_RS06700 (1362781) 1362781..1363179 + 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
QQK73_RS06705 (1363326) 1363326..1364189 + 864 WP_001267507.1 neutral zinc metallopeptidase -
QQK73_RS06710 (1364204) 1364204..1366219 + 2016 WP_000829323.1 tRNA cytosine(34) acetyltransferase TmcA -
QQK73_RS06715 (1366293) 1366293..1366991 + 699 WP_000679823.1 esterase -
QQK73_RS06720 (1367101) 1367101..1367301 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1259314..1407710 148396


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T44337 WP_000911330.1 NZ_AP027971:1362781-1363179 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

>T44337 NZ_AP027971:1362781-1363179 [Escherichia coli]
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTTATTGAAGGTTTCGTATCTCGTTTGGTAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACC
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTTACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGACTGGAGCTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8464.59 Da        Isoelectric Point: 4.3867

>AT44337 WP_284329794.1 NZ_AP027971:1362554-1362781 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWLDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp

>AT44337 NZ_AP027971:1362554-1362781 [Escherichia coli]
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAAGACGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGCTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References