Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3357612..3358230 Replicon chromosome
Accession NZ_AP027963
Organism Escherichia coli strain VE-T9

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QQK52_RS16350 Protein ID WP_001291435.1
Coordinates 3358012..3358230 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag QQK52_RS16345 Protein ID WP_089601776.1
Coordinates 3357612..3357986 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQK52_RS16335 (3352701) 3352701..3353894 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QQK52_RS16340 (3353917) 3353917..3357066 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
QQK52_RS16345 (3357612) 3357612..3357986 + 375 WP_089601776.1 Hha toxicity modulator TomB Antitoxin
QQK52_RS16350 (3358012) 3358012..3358230 + 219 WP_001291435.1 HHA domain-containing protein Toxin
QQK52_RS16355 (3358402) 3358402..3358953 + 552 WP_000102564.1 maltose O-acetyltransferase -
QQK52_RS16360 (3359069) 3359069..3359539 + 471 WP_000136192.1 YlaC family protein -
QQK52_RS16365 (3359703) 3359703..3361253 + 1551 WP_284345137.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QQK52_RS16370 (3361295) 3361295..3361648 - 354 Protein_3202 DUF1428 family protein -
QQK52_RS16380 (3362027) 3362027..3362338 + 312 WP_000409911.1 MGMT family protein -
QQK52_RS16385 (3362369) 3362369..3362941 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T44319 WP_001291435.1 NZ_AP027963:3358012-3358230 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T44319 NZ_AP027963:3358012-3358230 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTTTGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14587.42 Da        Isoelectric Point: 4.7395

>AT44319 WP_089601776.1 NZ_AP027963:3357612-3357986 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSSNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT44319 NZ_AP027963:3357612-3357986 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAAGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure

References