Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 2726116..2726914 | Replicon | chromosome |
| Accession | NZ_AP027963 | ||
| Organism | Escherichia coli strain VE-T9 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A3L4GA68 |
| Locus tag | QQK52_RS13370 | Protein ID | WP_000854898.1 |
| Coordinates | 2726116..2726493 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A3L4GA79 |
| Locus tag | QQK52_RS13375 | Protein ID | WP_001390639.1 |
| Coordinates | 2726540..2726914 (-) | Length | 125 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QQK52_RS13335 (2721704) | 2721704..2722258 | - | 555 | WP_001001902.1 | molecular chaperone YcdY | - |
| QQK52_RS13340 (2722282) | 2722282..2723019 | - | 738 | WP_000283664.1 | zinc-binding phosphatase | - |
| QQK52_RS13345 (2723074) | 2723074..2724012 | - | 939 | WP_284345316.1 | glyoxylate/hydroxypyruvate reductase GhrA | - |
| QQK52_RS13355 (2724483) | 2724483..2725325 | - | 843 | WP_072650511.1 | DUF4942 domain-containing protein | - |
| QQK52_RS13360 (2725422) | 2725422..2725619 | - | 198 | WP_000839285.1 | DUF957 domain-containing protein | - |
| QQK52_RS13365 (2725631) | 2725631..2726119 | - | 489 | WP_072650510.1 | DUF5983 family protein | - |
| QQK52_RS13370 (2726116) | 2726116..2726493 | - | 378 | WP_000854898.1 | TA system toxin CbtA family protein | Toxin |
| QQK52_RS13375 (2726540) | 2726540..2726914 | - | 375 | WP_001390639.1 | type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA | Antitoxin |
| QQK52_RS13380 (2726994) | 2726994..2727215 | - | 222 | WP_000692352.1 | DUF987 domain-containing protein | - |
| QQK52_RS13385 (2727302) | 2727302..2727778 | - | 477 | WP_001186768.1 | RadC family protein | - |
| QQK52_RS13390 (2727794) | 2727794..2728279 | - | 486 | WP_032180519.1 | antirestriction protein | - |
| QQK52_RS13395 (2728371) | 2728371..2729192 | - | 822 | WP_072652286.1 | DUF932 domain-containing protein | - |
| QQK52_RS13400 (2729413) | 2729413..2729823 | - | 411 | WP_000846713.1 | hypothetical protein | - |
| QQK52_RS13405 (2729839) | 2729839..2730516 | - | 678 | WP_284345315.1 | hypothetical protein | - |
| QQK52_RS13410 (2730652) | 2730652..2731722 | - | 1071 | WP_059239982.1 | patatin-like phospholipase family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14050.07 Da Isoelectric Point: 8.5190
>T44318 WP_000854898.1 NZ_AP027963:c2726493-2726116 [Escherichia coli]
MKTLSDTHVREVSRCPSPVTIWKTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGTSSQLINSIDILRARRATGLMTRSNYRTVNNITLGKHPEAKQ
MKTLSDTHVREVSRCPSPVTIWKTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGTSSQLINSIDILRARRATGLMTRSNYRTVNNITLGKHPEAKQ
Download Length: 378 bp
>T44318 NZ_AP027963:c2726493-2726116 [Escherichia coli]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGAAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGAATTTCACTGTGTGATGCAGTGAATTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAACTTCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCACGCCGGGCAACAGGTCTGATGACCCGCAG
CAACTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACAATGA
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGAAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGAATTTCACTGTGTGATGCAGTGAATTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAACTTCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCACGCCGGGCAACAGGTCTGATGACCCGCAG
CAACTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACAATGA
Antitoxin
Download Length: 125 a.a. Molecular weight: 13566.36 Da Isoelectric Point: 6.0568
>AT44318 WP_001390639.1 NZ_AP027963:c2726914-2726540 [Escherichia coli]
VSDTLPGTTLPDDNKDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTGG
ELNPRHQHTATLYAKGLTCEADTLGSCGYVYLAVYPTPAPATTS
VSDTLPGTTLPDDNKDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTGG
ELNPRHQHTATLYAKGLTCEADTLGSCGYVYLAVYPTPAPATTS
Download Length: 375 bp
>AT44318 NZ_AP027963:c2726914-2726540 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAACAAAGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTTGGCGCCCGTCTGGTGCAGGAGGGTAACCGCTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCAGGT
TCAGCGACGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCGGCGGT
GAACTGAATCCCCGACATCAGCATACCGCCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCGGCACCCGCAACCACTTCATAA
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAACAAAGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTTGGCGCCCGTCTGGTGCAGGAGGGTAACCGCTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCAGGT
TCAGCGACGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCGGCGGT
GAACTGAATCCCCGACATCAGCATACCGCCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCGGCACCCGCAACCACTTCATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3L4GA68 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3L4GA79 |