Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2352071..2352709 Replicon chromosome
Accession NZ_AP027963
Organism Escherichia coli strain VE-T9

Toxin (Protein)


Gene name hicA Uniprot ID A0A2X7GI71
Locus tag QQK52_RS11510 Protein ID WP_032231106.1
Coordinates 2352533..2352709 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag QQK52_RS11505 Protein ID WP_001270286.1
Coordinates 2352071..2352487 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQK52_RS11485 (2347223) 2347223..2348164 - 942 WP_284345245.1 ABC transporter permease -
QQK52_RS11490 (2348165) 2348165..2349178 - 1014 WP_000220405.1 ABC transporter ATP-binding protein -
QQK52_RS11495 (2349196) 2349196..2350341 - 1146 WP_284345246.1 ABC transporter substrate-binding protein -
QQK52_RS11500 (2350586) 2350586..2351992 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
QQK52_RS11505 (2352071) 2352071..2352487 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
QQK52_RS11510 (2352533) 2352533..2352709 - 177 WP_032231106.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
QQK52_RS11515 (2352931) 2352931..2353161 + 231 WP_000494244.1 YncJ family protein -
QQK52_RS11520 (2353253) 2353253..2355214 - 1962 WP_001491066.1 23S rRNA 5-hydroxycytidine C2501 synthase -
QQK52_RS11525 (2355287) 2355287..2355823 - 537 WP_000429151.1 DNA-binding transcriptional regulator SutR -
QQK52_RS11530 (2355876) 2355876..2357087 + 1212 WP_097346968.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6680.72 Da        Isoelectric Point: 10.9223

>T44317 WP_032231106.1 NZ_AP027963:c2352709-2352533 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPCHPSDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T44317 NZ_AP027963:c2352709-2352533 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTAAAACTCAG
GTTTCACGGGAGGCGCAGTGTCATGCCGTGTCACCCTAGCGATGAGATTAAAGAACCATTGCGTAAAGCAATTCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT44317 WP_001270286.1 NZ_AP027963:c2352487-2352071 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT44317 NZ_AP027963:c2352487-2352071 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2X7GI71

Antitoxin

Source ID Structure

References