Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 825375..826029 Replicon chromosome
Accession NZ_AP027963
Organism Escherichia coli strain VE-T9

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag QQK52_RS04145 Protein ID WP_097346894.1
Coordinates 825622..826029 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag QQK52_RS04140 Protein ID WP_000354046.1
Coordinates 825375..825641 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQK52_RS04115 (820544) 820544..821287 + 744 WP_284345197.1 SDR family oxidoreductase -
QQK52_RS04120 (821344) 821344..822777 - 1434 WP_284345196.1 6-phospho-beta-glucosidase BglA -
QQK52_RS04125 (822822) 822822..823133 + 312 WP_001182947.1 N(4)-acetylcytidine aminohydrolase -
QQK52_RS04130 (823297) 823297..823956 + 660 WP_000250274.1 hemolysin III family protein -
QQK52_RS04135 (824152) 824152..825132 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
QQK52_RS04140 (825375) 825375..825641 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
QQK52_RS04145 (825622) 825622..826029 + 408 WP_097346894.1 protein YgfX Toxin
QQK52_RS04150 (826069) 826069..826590 - 522 WP_001055874.1 flavodoxin FldB -
QQK52_RS04155 (826702) 826702..827598 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
QQK52_RS04160 (827623) 827623..828333 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QQK52_RS04165 (828339) 828339..830072 + 1734 WP_284345195.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16005.88 Da        Isoelectric Point: 11.5202

>T44305 WP_097346894.1 NZ_AP027963:825622-826029 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLSMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T44305 NZ_AP027963:825622-826029 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTCGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT44305 WP_000354046.1 NZ_AP027963:825375-825641 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT44305 NZ_AP027963:825375-825641 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References