Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 2314521..2315047 | Replicon | chromosome |
| Accession | NZ_AP027953 | ||
| Organism | Escherichia coli strain VE-F5 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | QQJ99_RS11410 | Protein ID | WP_000323025.1 |
| Coordinates | 2314760..2315047 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | QQJ99_RS11405 | Protein ID | WP_000534858.1 |
| Coordinates | 2314521..2314760 (+) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QQJ99_RS11370 (2309880) | 2309880..2310227 | - | 348 | WP_000612626.1 | IS66 family insertion sequence element accessory protein TnpB | - |
| QQJ99_RS11375 (2310224) | 2310224..2310628 | - | 405 | WP_000839179.1 | transposase | - |
| QQJ99_RS11380 (2310850) | 2310850..2311271 | + | 422 | Protein_2224 | hypothetical protein | - |
| QQJ99_RS11385 (2311927) | 2311927..2312997 | + | 1071 | Protein_2225 | ISNCY family transposase | - |
| QQJ99_RS11390 (2313070) | 2313070..2313219 | + | 150 | WP_011443592.1 | protein YdfW | - |
| QQJ99_RS11395 (2313656) | 2313656..2313988 | - | 333 | WP_001301033.1 | FlxA-like family protein | - |
| QQJ99_RS11400 (2314191) | 2314191..2314496 | - | 306 | WP_001326990.1 | protein YdfV | - |
| QQJ99_RS11405 (2314521) | 2314521..2314760 | + | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| QQJ99_RS11410 (2314760) | 2314760..2315047 | + | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| QQJ99_RS11415 (2315119) | 2315119..2315274 | + | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| QQJ99_RS11420 (2315491) | 2315491..2315742 | + | 252 | WP_000980994.1 | protein Rem | - |
| QQJ99_RS11425 (2315809) | 2315809..2316087 | + | 279 | WP_012304870.1 | hypothetical protein | - |
| QQJ99_RS11430 (2316089) | 2316089..2317138 | + | 1050 | WP_001265199.1 | DUF968 domain-containing protein | - |
| QQJ99_RS11435 (2317152) | 2317152..2317622 | + | 471 | Protein_2235 | antitermination protein | - |
| QQJ99_RS11440 (2317677) | 2317677..2318374 | + | 698 | WP_106423973.1 | IS1 family transposase | - |
| QQJ99_RS11445 (2318384) | 2318384..2319073 | + | 690 | WP_096949767.1 | phage minor tail protein L | - |
| QQJ99_RS11450 (2319079) | 2319079..2319822 | + | 744 | WP_000194783.1 | C40 family peptidase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2293779..2343912 | 50133 | |
| - | flank | IS/Tn | - | - | 2318081..2318374 | 293 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T44227 WP_000323025.1 NZ_AP027953:2314760-2315047 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T44227 NZ_AP027953:2314760-2315047 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT44227 WP_000534858.1 NZ_AP027953:2314521-2314760 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT44227 NZ_AP027953:2314521-2314760 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|