Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1881884..1882715 Replicon chromosome
Accession NZ_AP027953
Organism Escherichia coli strain VE-F5

Toxin (Protein)


Gene name yeeV Uniprot ID F4THW6
Locus tag QQJ99_RS09155 Protein ID WP_000854818.1
Coordinates 1881884..1882258 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID F4THW5
Locus tag QQJ99_RS09160 Protein ID WP_001313071.1
Coordinates 1882347..1882715 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQJ99_RS09115 (1877280) 1877280..1878446 + 1167 WP_001310935.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
QQJ99_RS09120 (1878565) 1878565..1879038 + 474 WP_001105393.1 DNA gyrase inhibitor SbmC -
QQJ99_RS09125 (1879236) 1879236..1880294 + 1059 WP_001200905.1 FUSC family protein -
QQJ99_RS09130 (1880466) 1880466..1880795 + 330 WP_000450409.1 DUF496 family protein -
QQJ99_RS09135 (1880896) 1880896..1881030 - 135 WP_001297944.1 EutP/PduV family microcompartment system protein -
QQJ99_RS09140 (1881132) 1881132..1881278 + 147 Protein_1787 transposase domain-containing protein -
QQJ99_RS09145 (1881567) 1881567..1881647 - 81 Protein_1788 hypothetical protein -
QQJ99_RS09150 (1881693) 1881693..1881887 - 195 WP_000988600.1 DUF5983 family protein -
QQJ99_RS09155 (1881884) 1881884..1882258 - 375 WP_000854818.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
QQJ99_RS09160 (1882347) 1882347..1882715 - 369 WP_001313071.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
QQJ99_RS09165 (1882795) 1882795..1883016 - 222 WP_000692301.1 DUF987 domain-containing protein -
QQJ99_RS09170 (1883079) 1883079..1883555 - 477 WP_001186726.1 RadC family protein -
QQJ99_RS09175 (1883571) 1883571..1884050 - 480 WP_000860076.1 antirestriction protein -
QQJ99_RS09180 (1884132) 1884132..1884953 - 822 WP_001234530.1 DUF932 domain-containing protein -
QQJ99_RS09185 (1885174) 1885174..1885506 - 333 Protein_1796 hypothetical protein -
QQJ99_RS09195 (1886352) 1886352..1886540 + 189 Protein_1798 IS4 family transposase -
QQJ99_RS09200 (1886519) 1886519..1886692 + 174 Protein_1799 cobalamin biosynthesis protein -
QQJ99_RS09205 (1886844) 1886844..1887389 + 546 WP_000973176.1 bifunctional adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13972.98 Da        Isoelectric Point: 7.1333

>T44218 WP_000854818.1 NZ_AP027953:c1882258-1881884 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T44218 NZ_AP027953:c1882258-1881884 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACTCCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCCGGCATTTCACTGTGCGATGCAGTGAACTTTCTTGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGAATTC
AGTGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCGACTGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13498.23 Da        Isoelectric Point: 5.8696

>AT44218 WP_001313071.1 NZ_AP027953:c1882715-1882347 [Escherichia coli]
VSDTLSGTTHPDDNNSHPWWGLPCTVTPCFGACLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT44218 NZ_AP027953:c1882715-1882347 [Escherichia coli]
GTGTCAGACACACTCTCCGGGACAACTCATCCCGATGACAACAACAGCCACCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCCTGTCTGGTGCAGGAGGGTAACCGGTTGCATTATCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3W3PHA3

Antitoxin

Source ID Structure
AlphaFold DB A0A1M1L2Z3

References