Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-DnaT |
| Location | 54276..54798 | Replicon | plasmid pVE-F10_2 |
| Accession | NZ_AP027948 | ||
| Organism | Escherichia coli strain VE-F10 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | U9YLU1 |
| Locus tag | QQK65_RS24165 | Protein ID | WP_000638823.1 |
| Coordinates | 54276..54557 (-) | Length | 94 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | U9Y7J1 |
| Locus tag | QQK65_RS24170 | Protein ID | WP_000121741.1 |
| Coordinates | 54547..54798 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QQK65_RS24130 (VEF10_46290) | 50425..50745 | - | 321 | WP_000362080.1 | VirB3 family type IV secretion system protein | - |
| QQK65_RS24135 (VEF10_46300) | 50816..51106 | - | 291 | WP_000865479.1 | conjugal transfer protein | - |
| QQK65_RS24140 (VEF10_46310) | 51106..51690 | - | 585 | WP_001177113.1 | lytic transglycosylase domain-containing protein | - |
| QQK65_RS24145 (VEF10_46320) | 51711..52109 | - | 399 | WP_001153665.1 | hypothetical protein | - |
| QQK65_RS24150 (VEF10_46330) | 52228..52665 | - | 438 | WP_000539665.1 | type IV pilus biogenesis protein PilM | - |
| QQK65_RS24155 (VEF10_46340) | 52671..53906 | - | 1236 | WP_072652802.1 | TcpQ domain-containing protein | - |
| QQK65_RS24160 (VEF10_46350) | 53909..54208 | - | 300 | WP_000835764.1 | TrbM/KikA/MpfK family conjugal transfer protein | - |
| QQK65_RS24165 (VEF10_46360) | 54276..54557 | - | 282 | WP_000638823.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| QQK65_RS24170 (VEF10_46370) | 54547..54798 | - | 252 | WP_000121741.1 | hypothetical protein | Antitoxin |
| QQK65_RS24175 | 54898..55533 | - | 636 | WP_015059536.1 | hypothetical protein | - |
| QQK65_RS24180 (VEF10_46380) | 55581..56390 | + | 810 | WP_171004827.1 | DUF5710 domain-containing protein | - |
| QQK65_RS24185 (VEF10_46390) | 56613..56837 | - | 225 | WP_000713562.1 | EexN family lipoprotein | - |
| QQK65_RS24190 (VEF10_46400) | 56846..57490 | - | 645 | WP_001310442.1 | type IV secretion system protein | - |
| QQK65_RS24195 (VEF10_46410) | 57496..58491 | - | 996 | WP_065304446.1 | type IV secretion system protein | - |
| QQK65_RS24200 (VEF10_46420) | 58495..58752 | - | 258 | WP_000739144.1 | hypothetical protein | - |
| QQK65_RS24205 (VEF10_46430) | 58749..59051 | - | 303 | WP_001360345.1 | hypothetical protein | - |
| QQK65_RS24210 | 59032..59289 | - | 258 | WP_001542015.1 | hypothetical protein | - |
| QQK65_RS24215 (VEF10_46440) | 59322..59768 | - | 447 | WP_001243165.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | mcr-1.1 | - | 1..63710 | 63710 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 94 a.a. Molecular weight: 10945.79 Da Isoelectric Point: 10.4997
>T44210 WP_000638823.1 NZ_AP027948:c54557-54276 [Escherichia coli]
MIYELAFDHRALKEWQKLGHTVREQFKKKLSERLINPRVPAAKLHGHTDRYKIKLRASGYRLVYQVIDEKVVLLVISVGK
REGSDVYHMADTR
MIYELAFDHRALKEWQKLGHTVREQFKKKLSERLINPRVPAAKLHGHTDRYKIKLRASGYRLVYQVIDEKVVLLVISVGK
REGSDVYHMADTR
Download Length: 282 bp
>T44210 NZ_AP027948:c54557-54276 [Escherichia coli]
ATGATTTATGAACTGGCATTTGACCACAGAGCACTGAAGGAATGGCAAAAACTCGGTCACACTGTTCGTGAGCAATTCAA
AAAGAAACTGTCAGAACGCCTGATAAATCCACGCGTCCCCGCAGCCAAGCTACATGGTCATACTGACCGTTACAAAATTA
AGCTTCGCGCATCCGGTTACAGGCTCGTTTATCAGGTAATTGATGAGAAGGTCGTTTTGCTTGTGATTTCTGTGGGAAAA
AGAGAAGGCAGCGACGTCTATCACATGGCAGATACCCGCTGA
ATGATTTATGAACTGGCATTTGACCACAGAGCACTGAAGGAATGGCAAAAACTCGGTCACACTGTTCGTGAGCAATTCAA
AAAGAAACTGTCAGAACGCCTGATAAATCCACGCGTCCCCGCAGCCAAGCTACATGGTCATACTGACCGTTACAAAATTA
AGCTTCGCGCATCCGGTTACAGGCTCGTTTATCAGGTAATTGATGAGAAGGTCGTTTTGCTTGTGATTTCTGTGGGAAAA
AGAGAAGGCAGCGACGTCTATCACATGGCAGATACCCGCTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9223.38 Da Isoelectric Point: 3.9823
>AT44210 WP_000121741.1 NZ_AP027948:c54798-54547 [Escherichia coli]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPELYAYYRELAEDAELNAIADERMKNPDIVRVNL
DDL
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPELYAYYRELAEDAELNAIADERMKNPDIVRVNL
DDL
Download Length: 252 bp
>AT44210 NZ_AP027948:c54798-54547 [Escherichia coli]
ATGAGCTACCAAATTCTGACTACGACAGCAGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACTGTAGCCGAAGG
AGAAGGGGATGCCGTCGCAATCCTGAACCGAAATGAACCAGCGTTCTACTGTGTCCCACCAGAACTTTATGCCTACTACC
GGGAACTCGCTGAAGACGCTGAACTCAACGCAATTGCTGATGAAAGAATGAAAAATCCAGACATTGTAAGGGTTAACCTG
GATGATTTATGA
ATGAGCTACCAAATTCTGACTACGACAGCAGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACTGTAGCCGAAGG
AGAAGGGGATGCCGTCGCAATCCTGAACCGAAATGAACCAGCGTTCTACTGTGTCCCACCAGAACTTTATGCCTACTACC
GGGAACTCGCTGAAGACGCTGAACTCAACGCAATTGCTGATGAAAGAATGAAAAATCCAGACATTGTAAGGGTTAACCTG
GATGATTTATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|