Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hicAB/- |
Location | 10725..11317 | Replicon | plasmid pVE-F10_2 |
Accession | NZ_AP027948 | ||
Organism | Escherichia coli strain VE-F10 |
Toxin (Protein)
Gene name | hicA | Uniprot ID | A0A1I9ZJC5 |
Locus tag | QQK65_RS23935 | Protein ID | WP_000513532.1 |
Coordinates | 10725..10973 (+) | Length | 83 a.a. |
Antitoxin (Protein)
Gene name | hicB | Uniprot ID | A0A1I9ZJ49 |
Locus tag | QQK65_RS23940 | Protein ID | WP_000681609.1 |
Coordinates | 10970..11317 (+) | Length | 116 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
QQK65_RS23900 (VEF10_45810) | 5729..6394 | - | 666 | WP_000532148.1 | division plane positioning ATPase MipZ | - |
QQK65_RS23905 (VEF10_45820) | 6983..7312 | + | 330 | WP_000855119.1 | hypothetical protein | - |
QQK65_RS23910 (VEF10_45830) | 7716..8231 | + | 516 | WP_001025393.1 | J domain-containing protein | - |
QQK65_RS23915 (VEF10_45840) | 8335..8877 | + | 543 | WP_001083904.1 | hypothetical protein | - |
QQK65_RS23920 (VEF10_45850) | 8874..9128 | + | 255 | WP_001230709.1 | hypothetical protein | - |
QQK65_RS23925 (VEF10_45860) | 9125..9367 | + | 243 | WP_000151456.1 | hypothetical protein | - |
QQK65_RS23930 (VEF10_45870) | 9938..10231 | + | 294 | WP_000673428.1 | hypothetical protein | - |
QQK65_RS23935 (VEF10_45890) | 10725..10973 | + | 249 | WP_000513532.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
QQK65_RS23940 (VEF10_45900) | 10970..11317 | + | 348 | WP_000681609.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
QQK65_RS23945 (VEF10_45910) | 11405..11848 | - | 444 | WP_023223351.1 | hypothetical protein | - |
QQK65_RS23950 (VEF10_45920) | 12089..12388 | + | 300 | WP_034169410.1 | type II toxin-antitoxin system HicB family antitoxin | - |
QQK65_RS23955 (VEF10_45930) | 12648..12974 | - | 327 | WP_000206697.1 | hypothetical protein | - |
QQK65_RS23960 (VEF10_45940) | 12976..13299 | - | 324 | WP_223666488.1 | hypothetical protein | - |
QQK65_RS23965 | 13276..13416 | - | 141 | Protein_21 | hypothetical protein | - |
QQK65_RS23970 (VEF10_45950) | 13436..14143 | - | 708 | WP_063084541.1 | hypothetical protein | - |
QQK65_RS23975 (VEF10_45960) | 14145..14897 | - | 753 | WP_000797967.1 | conjugal transfer protein TraL | - |
QQK65_RS23980 (VEF10_45970) | 14915..15316 | - | 402 | WP_063084542.1 | hypothetical protein | - |
QQK65_RS23985 (VEF10_45980) | 15684..16025 | + | 342 | WP_000730722.1 | plasmid mobilization relaxosome protein MobC | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Mobilizable plasmid | mcr-1.1 | - | 1..63710 | 63710 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 83 a.a. Molecular weight: 9378.03 Da Isoelectric Point: 10.4800
>T44209 WP_000513532.1 NZ_AP027948:10725-10973 [Escherichia coli]
MGKADKLLAKFLNSKKTFEWDELVVLFSSLGYVKKEMQGSRVRFFNAEINHTILMHRPHPESYIKGGTLKAIKQNLKEAG
VL
MGKADKLLAKFLNSKKTFEWDELVVLFSSLGYVKKEMQGSRVRFFNAEINHTILMHRPHPESYIKGGTLKAIKQNLKEAG
VL
Download Length: 249 bp
>T44209 NZ_AP027948:10725-10973 [Escherichia coli]
ATGGGGAAAGCAGATAAGCTACTGGCAAAATTTTTAAACAGTAAAAAAACGTTTGAATGGGATGAACTCGTTGTTTTGTT
TTCTTCTCTAGGATATGTCAAAAAGGAAATGCAGGGATCAAGAGTGCGATTTTTCAATGCTGAAATTAATCACACAATAT
TAATGCATCGCCCACATCCAGAAAGTTATATTAAAGGTGGAACGCTGAAAGCTATTAAACAGAACTTGAAAGAGGCTGGG
GTTTTATGA
ATGGGGAAAGCAGATAAGCTACTGGCAAAATTTTTAAACAGTAAAAAAACGTTTGAATGGGATGAACTCGTTGTTTTGTT
TTCTTCTCTAGGATATGTCAAAAAGGAAATGCAGGGATCAAGAGTGCGATTTTTCAATGCTGAAATTAATCACACAATAT
TAATGCATCGCCCACATCCAGAAAGTTATATTAAAGGTGGAACGCTGAAAGCTATTAAACAGAACTTGAAAGAGGCTGGG
GTTTTATGA
Antitoxin
Download Length: 116 a.a. Molecular weight: 13206.97 Da Isoelectric Point: 4.8313
>AT44209 WP_000681609.1 NZ_AP027948:10970-11317 [Escherichia coli]
MKHLKYKGYLGTVEPDFENNILYGKLAFIRDLVTYEAETLADLEREFKTSVDLYLQSCVEDGKEPDTPFKGVFNVRLDPE
LHRRVAEMAMEEDLSLNAFVNKALEKEVSHHRAGA
MKHLKYKGYLGTVEPDFENNILYGKLAFIRDLVTYEAETLADLEREFKTSVDLYLQSCVEDGKEPDTPFKGVFNVRLDPE
LHRRVAEMAMEEDLSLNAFVNKALEKEVSHHRAGA
Download Length: 348 bp
>AT44209 NZ_AP027948:10970-11317 [Escherichia coli]
ATGAAACATTTAAAATATAAAGGATATTTAGGTACGGTTGAGCCGGATTTTGAAAATAATATCCTGTATGGAAAGCTGGC
ATTTATTCGTGATCTGGTGACTTATGAGGCAGAAACATTGGCTGACCTGGAACGGGAATTTAAAACATCGGTTGATTTGT
ATTTACAGTCCTGTGTGGAGGACGGAAAGGAGCCTGACACGCCCTTTAAAGGTGTGTTTAACGTCAGGCTTGATCCAGAG
CTGCATCGTCGGGTCGCTGAAATGGCGATGGAAGAAGATTTGTCGCTGAATGCCTTTGTCAATAAGGCACTGGAAAAAGA
AGTCAGTCATCATCGCGCAGGGGCTTAA
ATGAAACATTTAAAATATAAAGGATATTTAGGTACGGTTGAGCCGGATTTTGAAAATAATATCCTGTATGGAAAGCTGGC
ATTTATTCGTGATCTGGTGACTTATGAGGCAGAAACATTGGCTGACCTGGAACGGGAATTTAAAACATCGGTTGATTTGT
ATTTACAGTCCTGTGTGGAGGACGGAAAGGAGCCTGACACGCCCTTTAAAGGTGTGTTTAACGTCAGGCTTGATCCAGAG
CTGCATCGTCGGGTCGCTGAAATGGCGATGGAAGAAGATTTGTCGCTGAATGCCTTTGTCAATAAGGCACTGGAAAAAGA
AGTCAGTCATCATCGCGCAGGGGCTTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1I9ZJC5 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1I9ZJ49 |