Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1629417..1630036 Replicon chromosome
Accession NZ_AP027926
Organism Escherichia fergusonii strain 30038

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag QUE84_RS07930 Protein ID WP_001280991.1
Coordinates 1629417..1629635 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID B7LLQ9
Locus tag QUE84_RS07935 Protein ID WP_000344803.1
Coordinates 1629662..1630036 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QUE84_RS07900 (1625073) 1625073..1625645 + 573 WP_000779831.1 YbaY family lipoprotein -
QUE84_RS07905 (1625676) 1625676..1625987 - 312 WP_000409907.1 MGMT family protein -
QUE84_RS07915 (1626366) 1626366..1626719 + 354 WP_000878140.1 DUF1428 domain-containing protein -
QUE84_RS07920 (1626761) 1626761..1628311 - 1551 WP_223689282.1 EAL domain-containing protein -
QUE84_RS07925 (1628450) 1628450..1628920 - 471 WP_002431406.1 YlaC family protein -
QUE84_RS07930 (1629417) 1629417..1629635 - 219 WP_001280991.1 HHA domain-containing protein Toxin
QUE84_RS07935 (1629662) 1629662..1630036 - 375 WP_000344803.1 Hha toxicity modulator TomB Antitoxin
QUE84_RS07940 (1630539) 1630539..1633688 - 3150 WP_001132493.1 efflux RND transporter permease AcrB -
QUE84_RS07945 (1633711) 1633711..1634904 - 1194 WP_002431407.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T44162 WP_001280991.1 NZ_AP027926:c1629635-1629417 [Escherichia fergusonii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T44162 NZ_AP027926:c1629635-1629417 [Escherichia fergusonii]
ATGTCCGATAAGCCTTTAACCAAAACTGATTATTTGATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAACGTGT
CATCGAAAAAAATAAATACGAACTCTCTGACAATGAACTGGCGGTATTTTATTCAGCAGCTGATCACCGTCTCGCTGAAT
TGACCATGAATAAACTTTACGACAAGATCCCCTCCTCCGTATGGAAATTCATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14525.33 Da        Isoelectric Point: 4.8989

>AT44162 WP_000344803.1 NZ_AP027926:c1630036-1629662 [Escherichia fergusonii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT44162 NZ_AP027926:c1630036-1629662 [Escherichia fergusonii]
ATGGACGAATACTCACCAAAACGACATGATATCGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAATCTTGAAGAGAGCAACCATGGCTGGGTTAACGACCCAACCTCGGCTATCAATCTGCAGCTCAACGAACTGATTGAGC
ATATTGCAACCTTCGCACTTAATTACAAAATTAAGTATAATGAGGACAATAAGCTCATAGAGCAGATCGATGAATATCTG
GATGACACTTTTATGTTGTTCAGTAGTTATGGCATTAATACACAGGATTTACAGAAATGGCGAAAATCTGGAAACAGGCT
CTTCCGCTGTTTTGTTAACGCCACCAGGGCGAACCCTGTTAGTTTGTCGTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A7K4HRV1

References