Detailed information of TA system TA044161

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelE-RHH
• Location: 1488991..1489538
• Replicon: chromosome
• Accession: NZ_AP027926
• Organism: Escherichia fergusonii strain 30038

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: QUE84_RS07270
• Protein ID: WP_244442846.1
• Coordinates: 1489260..1489538 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: E1QMW3
• Locus tag: QUE84_RS07265
• Protein ID: WP_000079941.1
• Coordinates: 1488991..1489260 (+)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QUE84_RS07240 (1484635)	1484635..1485168	-	534	WP_001303319.1	transcription termination/antitermination NusG family protein	-
QUE84_RS07245 (1485610)	1485610..1485897	-	288	WP_000074849.1	conjugal transfer protein TraA	-
QUE84_RS07250 (1485815)	1485815..1486045	-	231	WP_228772074.1	ash family protein	-
QUE84_RS07255 (1487051)	1487051..1488082	+	1032	WP_000907873.1	plasmid replication initiator RepA	-
QUE84_RS07260 (1488778)	1488778..1488936	+	159	WP_000841008.1	hypothetical protein	-
QUE84_RS07265 (1488991)	1488991..1489260	+	270	WP_000079941.1	type II toxin-antitoxin system antitoxin YacA	Antitoxin
QUE84_RS07270 (1489260)	1489260..1489538	+	279	WP_244442846.1	type II toxin-antitoxin system toxin YacB	Toxin
QUE84_RS07275 (1489578)	1489578..1490426	+	849	WP_001057996.1	3'-5' exonuclease	-
QUE84_RS07280 (1490543)	1490543..1491016	+	474	WP_001334658.1	hypothetical protein	-
QUE84_RS07285 (1491493)	1491493..1491759	-	267	WP_000955263.1	hypothetical protein	-
QUE84_RS07290 (1491759)	1491759..1492253	-	495	WP_001459505.1	hypothetical protein	-
QUE84_RS07295 (1492309)	1492309..1492911	-	603	WP_000517695.1	ProQ/FINO family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1471847..1502740	30893

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-91)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10761.43 Da
• Isoelectric Point: 9.7617

>T44161 WP_244442846.1 NZ_AP027926:1489260-1489538 [Escherichia fergusonii]
MEIFWTMLASQDRKRIRKYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP

Nucleotide

• Length: 279 bp

>T44161 NZ_AP027926:1489260-1489538 [Escherichia fergusonii]
ATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTAAGTACATTGCGGAGCAGAACCTGATGGC
CGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGCCGCAACGGTCGTG
TGGAAGGTACCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGACAGCCAGTGGGGAAAAGTGTAT
ATCCTGCGCGTGTTGCATACTGCACAGAAGTGGCCATAG

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10252.58 Da
• Isoelectric Point: 7.2057

>AT44161 WP_000079941.1 NZ_AP027926:1488991-1489260 [Escherichia fergusonii]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLPHDMVESSAAAWRD
EMSRKVAGK

Nucleotide

• Length: 270 bp

>AT44161 NZ_AP027926:1488991-1489260 [Escherichia fergusonii]
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATTCGGGATTTTATGCGCCAGACCGTTGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
AGGCAGGACGTCAGCAACTCGAGCGCGGCGATGTGCTTCCCCATGACATGGTCGAATCTTCCGCTGCTGCATGGCGGGAT
GAAATGAGCAGGAAGGTTGCCGGTAAATGA

Structures

Antitoxin

• AlphaFold DB: A0A629TXC5