Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 1399374..1400017 Replicon chromosome
Accession NZ_AP027926
Organism Escherichia fergusonii strain 30038

Toxin (Protein)


Gene name vagD Uniprot ID B1LRW4
Locus tag QUE84_RS06745 Protein ID WP_001044768.1
Coordinates 1399374..1399790 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID D2WFK3
Locus tag QUE84_RS06750 Protein ID WP_001261287.1
Coordinates 1399787..1400017 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QUE84_RS06725 (1395045) 1395045..1395401 - 357 WP_000002800.1 hypothetical protein -
QUE84_RS06730 (1395401) 1395401..1396558 - 1158 Protein_1303 lytic transglycosylase domain-containing protein -
QUE84_RS06735 (1396633) 1396633..1397337 + 705 WP_001067858.1 IS6-like element IS26 family transposase -
QUE84_RS06740 (1397440) 1397440..1399212 + 1773 WP_228295832.1 AAA family ATPase -
QUE84_RS06745 (1399374) 1399374..1399790 - 417 WP_001044768.1 type II toxin-antitoxin system VapC family toxin Toxin
QUE84_RS06750 (1399787) 1399787..1400017 - 231 WP_001261287.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
QUE84_RS06755 (1400313) 1400313..1400603 + 291 WP_000111771.1 hypothetical protein -
QUE84_RS06760 (1400593) 1400593..1401492 + 900 WP_000963206.1 nucleotide-binding protein -
QUE84_RS06765 (1401542) 1401542..1403767 - 2226 WP_000698737.1 P-loop NTPase fold protein -
QUE84_RS06770 (1403769) 1403769..1404857 - 1089 WP_000952217.1 transcriptional repressor PifC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1396633..1397337 704


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15197.66 Da        Isoelectric Point: 7.7805

>T44160 WP_001044768.1 NZ_AP027926:c1399790-1399374 [Escherichia fergusonii]
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDEFCARLDAILPWDRA
AVDATTKIKVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNTREFERVPDLVLEDWVK

Download         Length: 417 bp

>T44160 NZ_AP027926:c1399790-1399374 [Escherichia fergusonii]
GTGAACAAGACTTATATGCTTGATACCTGTATCTGCTCGTTCATCATGCGTGAACAGCCAGAAGCCGTCCTGAAGCGTCT
GGAGCAGGCGGTGCTACGCGGCCACCGTATAGTGGTCTCGGCCATCACCTACTCTGAAATGCGCTTCGGGGCTACCGGCC
CAAAGGCCTCACCACGTCACGTCCAACTGGTCGATGAATTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCC
GCAGTAGACGCCACCACGAAGATTAAAGTGGCACTGCGGCTGGCCGGGACGCCGATCGGCCCGAACGACACGGCGATTGC
CGGGCACGCCATCGCCGCCGGGGCGATACTGGTAACGAATAATACAAGAGAATTTGAGCGAGTGCCTGACCTGGTGCTGG
AAGACTGGGTGAAGTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8815.90 Da        Isoelectric Point: 4.3775

>AT44160 WP_001261287.1 NZ_AP027926:c1400017-1399787 [Escherichia fergusonii]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFLEYEKADPDFMAEREDVVSDEGRFNL

Download         Length: 231 bp

>AT44160 NZ_AP027926:c1400017-1399787 [Escherichia fergusonii]
ATGAGAACCGTATCGATATTCAAAAATGGCAACAACCGCGCCATCCGTCTGCCTCGTGATCTGGATTTTGAGGGGGTGAG
CGAGCTCGAGATCGTCCGGGAAGGGGACAGCATCATCCTGCGCCCCGTCCGGCCAACCTGGGGATCATTCCTAGAGTACG
AAAAAGCCGATCCAGATTTTATGGCGGAGCGCGAGGATGTTGTCAGCGACGAAGGGCGATTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A606Q844

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QFC4

References