Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 1592413..1592957 Replicon chromosome
Accession NZ_AP027741
Organism Methylophaga marina strain NBRC 102421

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag QUE24_RS08200 Protein ID WP_286303377.1
Coordinates 1592413..1592685 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag QUE24_RS08205 Protein ID WP_286303378.1
Coordinates 1592685..1592957 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QUE24_RS08175 (GCM10025856_16370) 1587738..1590002 + 2265 WP_286303372.1 nitric-oxide reductase large subunit -
QUE24_RS08180 (GCM10025856_16380) 1590033..1590431 + 399 WP_286303373.1 SirB2 family protein -
QUE24_RS08185 (GCM10025856_16390) 1590502..1590945 + 444 WP_286303374.1 CopD family protein -
QUE24_RS08190 (GCM10025856_16400) 1590972..1591319 + 348 WP_286303375.1 DUF488 family protein -
QUE24_RS08195 (GCM10025856_16410) 1591729..1592376 + 648 WP_286303376.1 hypothetical protein -
QUE24_RS08200 (GCM10025856_16420) 1592413..1592685 - 273 WP_286303377.1 type II toxin-antitoxin system YafQ family toxin Toxin
QUE24_RS08205 (GCM10025856_16430) 1592685..1592957 - 273 WP_286303378.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
QUE24_RS08210 (GCM10025856_16440) 1593267..1593647 - 381 WP_286303379.1 hypothetical protein -
QUE24_RS08215 (GCM10025856_16450) 1593846..1594787 + 942 WP_286303380.1 alpha/beta hydrolase -
QUE24_RS08220 (GCM10025856_16460) 1594918..1597734 - 2817 WP_286303381.1 mechanosensitive ion channel -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(3-83)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10514.27 Da        Isoelectric Point: 8.8661

>T44154 WP_286303377.1 NZ_AP027741:c1592685-1592413 [Methylophaga marina]
MLELEYSTQFKKDFKKIAKLSIPDIVEVGHVIKQLQLGKTLSEKYLDHPLSGDWKNYRDCHIKPDLVLIYKIDTDSLKLA
RIGTHSELFR

Download         Length: 273 bp

>T44154 NZ_AP027741:c1592685-1592413 [Methylophaga marina]
ATGCTTGAGCTCGAATACTCAACACAATTTAAAAAAGACTTTAAGAAAATTGCCAAACTATCCATACCCGATATCGTTGA
AGTGGGTCACGTCATAAAACAACTACAACTTGGCAAAACCTTATCTGAAAAATATCTAGATCACCCATTATCAGGTGATT
GGAAAAACTATCGTGATTGCCACATTAAACCTGACTTAGTTTTAATTTATAAAATTGATACAGATTCTTTAAAACTTGCA
AGAATCGGAACGCATAGCGAATTGTTCCGGTAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9721.15 Da        Isoelectric Point: 4.7557

>AT44154 WP_286303378.1 NZ_AP027741:c1592957-1592685 [Methylophaga marina]
MKTEMLSTRIDADTKLAFTNVCEDMGLSTSQALKLFAKAVVNYGGIPFELKVRQPNEITAAAIAELEAGNASSAKDVEEL
FSNLNIGKLR

Download         Length: 273 bp

>AT44154 NZ_AP027741:c1592957-1592685 [Methylophaga marina]
ATGAAGACAGAAATGCTAAGCACCCGAATTGATGCCGATACCAAATTGGCATTTACTAACGTATGCGAAGATATGGGATT
AAGCACCTCCCAGGCGCTAAAGCTATTTGCCAAAGCGGTGGTTAATTATGGTGGTATTCCTTTTGAACTTAAAGTGCGCC
AACCCAATGAGATAACCGCCGCTGCTATTGCTGAGCTTGAAGCTGGCAATGCCAGTTCTGCTAAAGATGTTGAAGAATTA
TTTAGCAATTTGAATATTGGAAAGCTTCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References