Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/YoeB-RelB
Location 752116..752626 Replicon chromosome
Accession NZ_AP027741
Organism Methylophaga marina strain NBRC 102421

Toxin (Protein)


Gene name relB Uniprot ID -
Locus tag QUE24_RS03765 Protein ID WP_286305318.1
Coordinates 752363..752626 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag QUE24_RS03760 Protein ID WP_286305317.1
Coordinates 752116..752370 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QUE24_RS03740 (GCM10025856_07420) 747681..748643 + 963 WP_286305314.1 DUF58 domain-containing protein -
QUE24_RS03745 (GCM10025856_07430) 748630..750678 + 2049 WP_286305315.1 DUF3488 and transglutaminase-like domain-containing protein -
QUE24_RS03750 (GCM10025856_07440) 750749..751486 + 738 WP_284451802.1 tRNA threonylcarbamoyladenosine dehydratase -
QUE24_RS03755 (GCM10025856_07450) 751479..751982 + 504 WP_286305316.1 hypothetical protein -
QUE24_RS03760 (GCM10025856_07460) 752116..752370 + 255 WP_286305317.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
QUE24_RS03765 (GCM10025856_07470) 752363..752626 + 264 WP_286305318.1 Txe/YoeB family addiction module toxin Toxin
QUE24_RS03770 (GCM10025856_07480) 752820..753314 + 495 WP_286305319.1 YbaK/EbsC family protein -
QUE24_RS03775 (GCM10025856_07490) 753376..755421 - 2046 WP_286305320.1 mechanosensitive ion channel -
QUE24_RS03780 755418..755774 - 357 WP_286305321.1 hypothetical protein -
QUE24_RS03785 (GCM10025856_07500) 755985..756860 + 876 WP_286305322.1 MFS transporter -
QUE24_RS03790 (GCM10025856_07510) 756842..757201 + 360 WP_286305323.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10340.86 Da        Isoelectric Point: 9.9410

>T44153 WP_286305318.1 NZ_AP027741:752363-752626 [Methylophaga marina]
MSKRLLTWTDEAWNSYLYWQTQDKKTLKRINKLIADVKRSPFEGIGKPEALKENLSGFWSRRIDDINRLVYAVDNSAITI
ISCRYHY

Download         Length: 264 bp

>T44153 NZ_AP027741:752363-752626 [Methylophaga marina]
ATGAGTAAACGACTGCTGACATGGACAGATGAAGCATGGAATAGCTATTTATATTGGCAGACACAAGACAAAAAAACGCT
CAAACGAATCAATAAGTTGATTGCTGATGTTAAACGCTCCCCATTTGAAGGCATAGGAAAACCAGAGGCCTTAAAAGAAA
ACTTGTCTGGCTTTTGGTCACGGAGAATCGATGACATCAATAGATTAGTCTATGCCGTCGATAACAGTGCTATAACTATT
ATTTCCTGCCGCTATCATTATTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9536.86 Da        Isoelectric Point: 7.2010

>AT44153 WP_286305317.1 NZ_AP027741:752116-752370 [Methylophaga marina]
MKVVSFTEARNSLKAVLDRVINDADTTVISRRDSQDAVVMSLDYYNSLMETVHLLRSPANVEHLNKSIAQYKQGKVAERK
LLDE

Download         Length: 255 bp

>AT44153 NZ_AP027741:752116-752370 [Methylophaga marina]
ATGAAAGTTGTTTCTTTTACAGAAGCGCGTAATAGTTTGAAGGCTGTTTTAGATCGAGTTATCAATGATGCCGACACCAC
AGTTATTTCACGTCGAGACTCTCAGGATGCGGTGGTAATGTCATTAGATTATTACAATAGTCTAATGGAAACCGTTCATT
TACTTCGTTCCCCCGCAAACGTTGAGCATCTGAATAAATCCATTGCTCAGTATAAACAAGGAAAAGTTGCAGAACGGAAA
TTACTGGATGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References