Detailed information of TA system TA044151

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 2563949..2564595
• Replicon: chromosome
• Accession: NZ_AP027737
• Organism: Agromyces mangrovi strain NBRC 112812

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: QUE38_RS12140
• Protein ID: WP_286308501.1
• Coordinates: 2563949..2564368 (-)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: QUE38_RS12145
• Protein ID: WP_286308502.1
• Coordinates: 2564365..2564595 (-)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QUE38_RS12115 (GCM10025877_24370)	2559998..2560513	-	516	WP_286308497.1	hypothetical protein	-
QUE38_RS12120 (GCM10025877_24380)	2560699..2561751	+	1053	WP_286308498.1	2,3-butanediol dehydrogenase	-
QUE38_RS12125 (GCM10025877_24390)	2561982..2562656	-	675	WP_286308499.1	LysR substrate-binding domain-containing protein	-
QUE38_RS12130	2562548..2562850	-	303	WP_286311812.1	LysR family transcriptional regulator	-
QUE38_RS12135 (GCM10025877_24400)	2562972..2563904	+	933	WP_286308500.1	aldo/keto reductase	-
QUE38_RS12140 (GCM10025877_24410)	2563949..2564368	-	420	WP_286308501.1	type II toxin-antitoxin system VapC family toxin	Toxin
QUE38_RS12145 (GCM10025877_24420)	2564365..2564595	-	231	WP_286308502.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
QUE38_RS12150 (GCM10025877_24430)	2564804..2565235	+	432	WP_286308503.1	DUF805 domain-containing protein	-
QUE38_RS12155 (GCM10025877_24440)	2565277..2565624	+	348	WP_286308504.1	hypothetical protein	-
QUE38_RS12160 (GCM10025877_24450)	2565783..2566352	+	570	WP_286308505.1	hypothetical protein	-
QUE38_RS12165 (GCM10025877_24460)	2566369..2567391	+	1023	WP_286308506.1	hypothetical protein	-
QUE38_RS12170 (GCM10025877_24470)	2567501..2568757	-	1257	WP_286308507.1	endonuclease/exonuclease/phosphatase family protein	-
QUE38_RS12175 (GCM10025877_24480)	2568900..2569241	-	342	WP_286308508.1	YciI family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-125)

Antitoxin

• SpoVT-AbrB domain (7-47)

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 14967.12 Da
• Isoelectric Point: 10.0478

>T44151 WP_286308501.1 NZ_AP027737:c2564368-2563949 [Agromyces mangrovi]
VSARVLLDTNILIFALRNRTPGLRERMRAQAGRMAVSSISVAELAYGVERSSDPARNRRATEELLALTTRLALEERAAEH
AGEIRAALAAAGTPIGAYDVLLAGHARSAGLTLVTNNVREFARVPGLLVEDWTVEPPAR

Nucleotide

• Length: 420 bp

>T44151 NZ_AP027737:c2564368-2563949 [Agromyces mangrovi]
GTGAGCGCGAGGGTCCTGCTCGACACGAACATCCTGATCTTCGCGCTGCGCAATCGCACGCCGGGGCTGCGCGAGCGCAT
GCGCGCCCAAGCGGGACGGATGGCCGTGTCGTCCATCAGCGTCGCCGAACTCGCGTACGGCGTCGAGCGCTCGAGCGACC
CGGCGCGCAACCGGCGCGCGACCGAGGAACTGCTCGCGCTGACCACGAGGCTCGCGCTCGAGGAACGCGCCGCCGAGCAT
GCCGGCGAGATCCGTGCGGCGCTCGCGGCGGCGGGCACGCCGATCGGCGCCTACGACGTGCTCCTCGCCGGCCACGCCCG
CAGCGCGGGGCTCACGCTCGTCACGAACAACGTGCGCGAGTTCGCGCGCGTGCCCGGCCTGCTCGTCGAGGACTGGACCG
TCGAGCCGCCGGCACGATGA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8395.42 Da
• Isoelectric Point: 4.5086

>AT44151 WP_286308502.1 NZ_AP027737:c2564595-2564365 [Agromyces mangrovi]
MTRASVFRTNRTQAVRLPKEVALPDDVRAVDVTVVGDARILTPVGGAIDFWFDHGVTVTDDFLAERDQGEQERPGL

Nucleotide

• Length: 231 bp

>AT44151 NZ_AP027737:c2564595-2564365 [Agromyces mangrovi]
ATGACCCGAGCGAGCGTGTTCCGCACGAACCGCACGCAGGCGGTGCGGCTTCCGAAGGAGGTCGCCCTGCCCGATGACGT
GCGCGCCGTCGACGTGACGGTCGTGGGCGACGCCCGCATCCTCACCCCCGTCGGAGGCGCGATCGACTTCTGGTTCGACC
ACGGCGTGACGGTGACGGACGACTTCCTCGCCGAGCGCGATCAGGGCGAGCAGGAGCGGCCCGGCCTGTGA