Detailed information of TA system TA044150

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 2547975..2548633
• Replicon: chromosome
• Accession: NZ_AP027737
• Organism: Agromyces mangrovi strain NBRC 112812

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: QUE38_RS12065
• Protein ID: WP_286308488.1
• Coordinates: 2548199..2548633 (+)
• Length: 145 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: QUE38_RS12060
• Protein ID: WP_286308487.1
• Coordinates: 2547975..2548202 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QUE38_RS12050 (GCM10025877_24250)	2543186..2546686	+	3501	WP_286308485.1	glycosyl hydrolase	-
QUE38_RS12055 (GCM10025877_24260)	2546749..2547711	-	963	WP_286308486.1	NAD(P)/FAD-dependent oxidoreductase	-
QUE38_RS12060 (GCM10025877_24270)	2547975..2548202	+	228	WP_286308487.1	hypothetical protein	Antitoxin
QUE38_RS12065 (GCM10025877_24280)	2548199..2548633	+	435	WP_286308488.1	PIN domain-containing protein	Toxin
QUE38_RS12070 (GCM10025877_24290)	2548743..2549675	+	933	WP_286308489.1	DNA-formamidopyrimidine glycosylase family protein	-
QUE38_RS12075	2549728..2550513	+	786	WP_286308490.1	MBL fold metallo-hydrolase	-
QUE38_RS12080 (GCM10025877_24300)	2550510..2550938	+	429	WP_286308491.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (7-128)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 145 a.a.
• Molecular weight: 15191.40 Da
• Isoelectric Point: 6.1193

>T44150 WP_286308488.1 NZ_AP027737:2548199-2548633 [Agromyces mangrovi]
MTAPARLLDANVLIALVAPQHAHHAAAHRWFAGVDAWATTPLTEAAFVRLVANPAVTGAPHTPAEALDLLRRLRSIPGHT
FVQDDVSLVDTSVDLGALVGYRQVTDFHLLALAAANGLVLATFDARLRAAVAPDDQGSIELIPV

Nucleotide

• Length: 435 bp

>T44150 NZ_AP027737:2548199-2548633 [Agromyces mangrovi]
ATGACCGCACCGGCGCGGCTCCTCGATGCGAACGTGCTGATCGCGCTGGTCGCTCCGCAACACGCGCACCATGCAGCCGC
GCACCGCTGGTTCGCTGGCGTGGATGCATGGGCGACGACCCCGCTGACGGAGGCTGCGTTCGTTCGTCTGGTTGCGAACC
CCGCGGTCACGGGTGCCCCGCACACGCCTGCCGAGGCGTTGGACCTGCTGCGGCGGCTGCGGAGCATTCCCGGCCACACC
TTCGTCCAGGATGATGTCTCGCTGGTGGACACGTCGGTCGATCTCGGTGCGCTCGTCGGCTATCGCCAGGTGACGGACTT
CCACCTGCTCGCGCTCGCAGCCGCGAACGGCCTCGTGCTGGCAACCTTCGACGCGCGGTTGCGCGCGGCCGTGGCCCCCG
ATGACCAGGGCTCGATCGAGCTGATCCCCGTCTGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 7769.70 Da
• Isoelectric Point: 4.2811

>AT44150 WP_286308487.1 NZ_AP027737:2547975-2548202 [Agromyces mangrovi]
MRTTLDLDAGVLRAARALADHERISLGAAVSELARRGMVTGPGAVAPDGFPILAQGSADFVITSDVVADYRDDEG

Nucleotide

• Length: 228 bp

>AT44150 NZ_AP027737:2547975-2548202 [Agromyces mangrovi]
ATGCGAACGACTCTCGACCTGGACGCCGGCGTGCTACGCGCTGCGCGCGCGCTCGCTGACCATGAGCGCATCTCGCTGGG
GGCTGCGGTGTCGGAGCTCGCGCGGCGTGGAATGGTGACCGGGCCGGGTGCAGTCGCACCCGACGGCTTCCCGATCCTTG
CGCAGGGCTCGGCTGACTTCGTGATCACGTCCGACGTCGTCGCTGACTATCGAGACGACGAGGGATGA