Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 456593..457242 Replicon chromosome
Accession NZ_AP027737
Organism Agromyces mangrovi strain NBRC 112812

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag QUE38_RS02110 Protein ID WP_286309930.1
Coordinates 456593..457012 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag QUE38_RS02115 Protein ID WP_286309931.1
Coordinates 457009..457242 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QUE38_RS02085 (GCM10025877_04160) 452322..453860 + 1539 WP_286309925.1 hypothetical protein -
QUE38_RS02090 (GCM10025877_04170) 453960..454322 + 363 WP_286309926.1 helix-turn-helix domain-containing protein -
QUE38_RS02095 (GCM10025877_04180) 454324..455304 + 981 WP_286309927.1 SRPBCC family protein -
QUE38_RS02100 (GCM10025877_04190) 455415..456089 + 675 WP_286309928.1 VOC family protein -
QUE38_RS02105 (GCM10025877_04200) 456119..456568 + 450 WP_286309929.1 hypothetical protein -
QUE38_RS02110 (GCM10025877_04210) 456593..457012 - 420 WP_286309930.1 type II toxin-antitoxin system VapC family toxin Toxin
QUE38_RS02115 (GCM10025877_04220) 457009..457242 - 234 WP_286309931.1 Arc family DNA-binding protein Antitoxin
QUE38_RS02120 (GCM10025877_04230) 457387..457734 + 348 WP_286309932.1 hypothetical protein -
QUE38_RS02125 (GCM10025877_04240) 457751..458824 - 1074 WP_286309935.1 redox-regulated ATPase YchF -
QUE38_RS02130 (GCM10025877_04250) 458907..459518 - 612 WP_286309936.1 dihydrofolate reductase family protein -
QUE38_RS02135 (GCM10025877_04260) 459667..460284 + 618 WP_286309937.1 3'-5' exonuclease -
QUE38_RS02140 (GCM10025877_04270) 460340..461839 + 1500 WP_286309938.1 DNA recombination protein RmuC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-128)

Antitoxin

Arc-like DNA binding domain

(11-40)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14858.93 Da        Isoelectric Point: 4.5746

>T44147 WP_286309930.1 NZ_AP027737:c457012-456593 [Agromyces mangrovi]
VIVLDTNVISELVRPRPDPNVVAWLEGLAEDAAITAVTLAELMAGLLRLPDGRRRDLLTASVHAAVEPYRATAAVLAFDA
HAADQYAEIVVARDLLGRPISTADAQIAAICRARNATCATRNTKDFESTGVELLDPWSA

Download         Length: 420 bp

>T44147 NZ_AP027737:c457012-456593 [Agromyces mangrovi]
GTGATCGTTCTCGACACGAACGTCATCTCGGAGTTGGTCCGACCGCGCCCGGATCCGAATGTCGTCGCATGGCTCGAGGG
GCTGGCCGAGGATGCTGCAATCACCGCCGTCACGCTCGCCGAGCTGATGGCCGGACTCCTGCGGCTCCCGGACGGTCGGC
GCAGGGACCTGCTCACCGCGAGCGTGCATGCGGCGGTCGAGCCGTATCGGGCGACCGCGGCCGTGCTTGCGTTCGATGCG
CATGCCGCGGACCAGTATGCCGAGATCGTGGTCGCTCGCGACCTCCTCGGAAGGCCCATCAGTACAGCCGATGCCCAGAT
CGCTGCGATCTGTCGTGCCCGCAACGCGACGTGTGCGACCCGGAACACGAAGGACTTCGAATCGACAGGCGTGGAGCTTC
TCGACCCTTGGTCTGCGTAG

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8151.27 Da        Isoelectric Point: 5.0790

>AT44147 WP_286309931.1 NZ_AP027737:c457242-457009 [Agromyces mangrovi]
MASIVVRGLDESVKEQLAAQAKEHGRSMEAEVREILTKAANRPNIGLAILRAAQAAGGVDELPVPERSDVARAVDFG

Download         Length: 234 bp

>AT44147 NZ_AP027737:c457242-457009 [Agromyces mangrovi]
ATGGCATCGATCGTCGTTCGTGGACTCGATGAGTCCGTGAAAGAACAGCTTGCCGCGCAGGCGAAGGAGCACGGTCGCTC
GATGGAGGCCGAAGTACGCGAGATCCTCACCAAGGCCGCGAACCGACCGAACATCGGACTCGCAATCCTGCGGGCCGCGC
AGGCCGCGGGTGGGGTCGATGAACTGCCGGTTCCCGAGCGCTCTGACGTTGCACGTGCGGTGGACTTCGGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References