Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2657722..2658343 Replicon chromosome
Accession NZ_AP027735
Organism Barrientosiimonas endolithica strain NBRC 110608

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag QUE40_RS13500 Protein ID WP_289231307.1
Coordinates 2657957..2658343 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag QUE40_RS13495 Protein ID WP_142006222.1
Coordinates 2657722..2657955 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QUE40_RS13475 (GCM10025872_27930) 2652993..2654699 - 1707 WP_289231304.1 GMC family oxidoreductase -
QUE40_RS13480 (GCM10025872_27940) 2654696..2655469 - 774 WP_289231305.1 aldehyde dehydrogenase family protein -
QUE40_RS13485 (GCM10025872_27950) 2655367..2656308 - 942 WP_289231306.1 aldehyde dehydrogenase family protein -
QUE40_RS13490 (GCM10025872_27960) 2656529..2657650 - 1122 WP_142006220.1 GuaB3 family IMP dehydrogenase-related protein -
QUE40_RS13495 (GCM10025872_27970) 2657722..2657955 + 234 WP_142006222.1 antitoxin Antitoxin
QUE40_RS13500 (GCM10025872_27980) 2657957..2658343 + 387 WP_289231307.1 type II toxin-antitoxin system VapC family toxin Toxin
QUE40_RS13505 (GCM10025872_27990) 2658499..2660025 - 1527 WP_142006223.1 IMP dehydrogenase -
QUE40_RS13510 (GCM10025872_28000) 2660164..2660745 + 582 WP_289231308.1 hypothetical protein -
QUE40_RS13515 2660933..2661178 - 246 WP_289231309.1 hypothetical protein -
QUE40_RS13520 2661175..2661300 - 126 WP_289233089.1 sigma factor-like helix-turn-helix DNA-binding protein -
QUE40_RS13525 (GCM10025872_28010) 2661258..2661668 - 411 WP_289231310.1 sigma factor -
QUE40_RS13530 (GCM10025872_28020) 2662100..2662357 + 258 WP_142006229.1 RNA-binding S4 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Pae0151-like, PIN domain

(3-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 13495.52 Da        Isoelectric Point: 5.6741

>T44144 WP_289231307.1 NZ_AP027735:2657957-2658343 [Barrientosiimonas endolithica]
VLVIDASALVLAVVDTTSRGAAVRQQLLSGVAAPHLVDAECGQALRGLVHRGVLPADRAATSLAAARDLVVQRYPVAPLQ
SRAWELRDSLSFYDATYVALAEVLDARLLTADRRLATAPGPECPIDLA

Download         Length: 387 bp

>T44144 NZ_AP027735:2657957-2658343 [Barrientosiimonas endolithica]
GTGCTCGTCATCGACGCCTCCGCCCTGGTCCTGGCCGTCGTCGACACCACGAGCCGCGGCGCAGCCGTGCGCCAGCAGCT
CCTGTCCGGCGTCGCCGCCCCGCACCTCGTCGACGCGGAGTGCGGTCAGGCGTTGCGCGGGCTCGTCCACCGCGGGGTGC
TGCCCGCCGACCGAGCCGCCACCTCGCTGGCCGCGGCGCGCGACCTCGTCGTCCAGCGCTACCCCGTCGCCCCGCTGCAG
TCCAGAGCCTGGGAGCTGCGCGACAGCCTCAGCTTCTACGACGCGACCTACGTCGCGCTCGCCGAGGTGCTCGACGCGCG
ACTTCTCACCGCCGACCGACGGCTCGCGACCGCGCCCGGCCCCGAGTGCCCCATCGACCTCGCCTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8742.90 Da        Isoelectric Point: 4.7872

>AT44144 WP_142006222.1 NZ_AP027735:2657722-2657955 [Barrientosiimonas endolithica]
MALIQIRDVPEDVYETIRRRARRSGQSIQAYMLARTVEVGRRPEPDEVVQALEDDLAGRPPLTLDVNQVLAARDADR

Download         Length: 234 bp

>AT44144 NZ_AP027735:2657722-2657955 [Barrientosiimonas endolithica]
ATGGCCCTGATCCAGATCCGCGACGTGCCCGAGGACGTCTACGAGACGATCCGCCGCCGGGCGCGCCGGTCGGGCCAGTC
GATCCAGGCGTACATGCTCGCCCGGACGGTCGAGGTGGGCCGACGGCCCGAGCCCGACGAGGTCGTGCAAGCCCTCGAGG
ACGACCTCGCCGGTCGCCCGCCGCTGACCCTCGACGTCAACCAGGTGCTCGCCGCGCGCGACGCCGACCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References