Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2975363..2976711 Replicon chromosome
Accession NZ_AP027732
Organism Frondihabitans sucicola strain NBRC 108728

Toxin (Protein)


Gene name HipA3 Uniprot ID -
Locus tag QUE79_RS15335 Protein ID WP_286343833.1
Coordinates 2975623..2976711 (+) Length 363 a.a.

Antitoxin (Protein)


Gene name HipB3 Uniprot ID -
Locus tag QUE79_RS15330 Protein ID WP_286343832.1
Coordinates 2975363..2975623 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QUE79_RS15295 2970363..2970626 + 264 WP_286346871.1 hypothetical protein -
QUE79_RS15300 2970655..2971032 - 378 Protein_3017 ABC transporter permease -
QUE79_RS15305 (GCM10025867_31930) 2971029..2971706 - 678 WP_286343828.1 ABC transporter permease subunit -
QUE79_RS15310 (GCM10025867_31940) 2971762..2972565 - 804 WP_286343829.1 ATP-binding cassette domain-containing protein -
QUE79_RS15315 (GCM10025867_31950) 2972693..2973373 - 681 WP_286343830.1 TetR/AcrR family transcriptional regulator -
QUE79_RS15320 (GCM10025867_31960) 2973440..2974132 + 693 WP_286343831.1 SOS response-associated peptidase -
QUE79_RS15325 2974221..2975220 + 1000 Protein_3022 DUF2183 domain-containing protein -
QUE79_RS15330 (GCM10025867_31980) 2975363..2975623 + 261 WP_286343832.1 helix-turn-helix transcriptional regulator Antitoxin
QUE79_RS15335 (GCM10025867_31990) 2975623..2976711 + 1089 WP_286343833.1 type II toxin-antitoxin system HipA family toxin Toxin
QUE79_RS15340 (GCM10025867_32000) 2976711..2976908 + 198 WP_286343834.1 hypothetical protein -
QUE79_RS15345 (GCM10025867_32010) 2976970..2977725 - 756 WP_286343835.1 SDR family NAD(P)-dependent oxidoreductase -
QUE79_RS15350 (GCM10025867_32020) 2977967..2978188 + 222 WP_286343836.1 hypothetical protein -
QUE79_RS15355 (GCM10025867_32030) 2978243..2980230 + 1988 Protein_3028 glycoside hydrolase family 15 protein -
QUE79_RS15360 (GCM10025867_32040) 2980330..2981706 - 1377 WP_286343837.1 glucose-6-phosphate dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(10-121)

Antitoxin

Cro/C1-type helix-turn-helix domain

(2-48)


Sequences

Toxin        


Download         Length: 363 a.a.        Molecular weight: 39603.70 Da        Isoelectric Point: 5.7574

>T44139 WP_286343833.1 NZ_AP027732:2975623-2976711 [Frondihabitans sucicola]
MAYTPVAAVEVTAWGLRVGAVAPDPRLGAYVFEYYPDWIARGIELAPLEMPLSRQRYVFPALPENTFHRLPAMLADALPD
DFGNAIIDAWLARQGIRRGEVTPLDRLAYMSNRAMGALEFRPSRGPRQRVTSAVQMSDLVEGARSVLDERFAGDRETEAA
IQSLIQVGTSAGGARAKAVIAWNRETGEIRSGQLPAADGFEFWLIKLDGVGRDAELGSGGEYGRVEYAYSLMAGAAGLDM
TECRLLEENGRAHFMTRRYDRGGPDGKVHALTLCGLTQLDFRQRQTHDYSQYFDAIERLGLGPAAKEQAFRRMVFNVLAA
NCDDHSKNESFLLSGPTGSWALSPPTTSPSPTTPRVSGPTST

Download         Length: 1089 bp

>T44139 NZ_AP027732:2975623-2976711 [Frondihabitans sucicola]
ATGGCCTACACGCCCGTCGCAGCCGTCGAGGTCACCGCCTGGGGCCTGCGGGTCGGCGCCGTCGCCCCCGATCCGCGCCT
CGGCGCCTACGTGTTCGAGTACTACCCCGACTGGATCGCCCGCGGAATCGAGCTCGCCCCGCTCGAGATGCCGCTGTCGC
GGCAGCGCTACGTCTTCCCGGCCCTTCCCGAGAACACGTTCCACCGACTGCCCGCGATGCTGGCCGACGCTCTCCCCGAC
GACTTCGGAAACGCGATCATCGACGCGTGGCTCGCCAGGCAGGGCATCCGCCGCGGCGAGGTGACACCGCTCGACCGCCT
GGCGTACATGTCGAACCGAGCGATGGGCGCCCTCGAGTTCCGGCCGTCGCGGGGGCCGCGGCAGCGGGTCACCAGCGCCG
TCCAGATGAGCGACCTCGTCGAGGGTGCCCGCAGCGTGCTCGACGAGCGCTTCGCCGGCGATCGCGAGACCGAGGCGGCC
ATCCAGAGCCTCATCCAGGTCGGCACGTCCGCGGGCGGAGCGCGGGCCAAGGCGGTCATCGCCTGGAACCGCGAGACGGG
CGAGATCCGCTCCGGCCAGCTCCCCGCCGCCGACGGCTTCGAGTTCTGGCTGATCAAGCTCGACGGTGTGGGTCGCGACG
CCGAGCTCGGTTCGGGAGGCGAGTACGGCAGGGTCGAGTACGCCTACTCGCTGATGGCCGGTGCCGCCGGGCTCGACATG
ACCGAGTGCCGCCTCCTCGAAGAGAACGGTCGCGCCCACTTCATGACCAGGCGGTACGACCGAGGCGGACCGGACGGCAA
GGTGCACGCGCTCACCCTCTGCGGCCTGACCCAGCTCGACTTCCGGCAGCGCCAGACCCACGACTACAGCCAGTACTTCG
ACGCGATCGAGCGCCTCGGGCTCGGCCCCGCCGCGAAGGAGCAGGCGTTCCGCCGCATGGTGTTCAACGTGCTCGCCGCC
AACTGCGACGACCACTCGAAGAACGAGTCGTTCCTGCTGTCGGGGCCGACGGGATCCTGGGCCCTCTCCCCGCCTACGAC
GTCACCTTCGCCTACAACCCCACGGGTCAGTGGACCTACCAGCACCTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9486.78 Da        Isoelectric Point: 11.0590

>AT44139 WP_286343832.1 NZ_AP027732:2975363-2975623 [Frondihabitans sucicola]
MRALRLDRGYDQATLGDLADVSVTSIKNLENGRGSSLRTVIRILRALEATAWLDTLAPTPTVSPIDLLRSAEATPRRRVS
RPRSDD

Download         Length: 261 bp

>AT44139 NZ_AP027732:2975363-2975623 [Frondihabitans sucicola]
ATGCGCGCCCTCCGACTCGACCGCGGCTACGACCAGGCCACCCTCGGCGATCTCGCCGATGTGAGCGTCACCTCGATCAA
GAATCTCGAGAACGGCCGAGGAAGCTCTCTCCGCACCGTGATCAGGATCCTGCGAGCCCTCGAGGCGACGGCGTGGCTCG
ACACGCTGGCCCCGACGCCGACGGTGAGTCCGATCGACCTGCTGCGCAGCGCCGAAGCCACCCCGAGACGACGAGTCTCC
CGACCGAGGAGCGACGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References